EFSA
ecomole
vscht
  2. Rauvolfia serpentina (L.) Benth. ex Kurz // Ophioxylon serpentinum L. // Ophioxylon trifoliatum Gaertn. // Rauvolfia trifoliata (Gaertn.) Baill.

Rauvolfia serpentina (L.) Benth. ex Kurz // Ophioxylon serpentinum L. // Ophioxylon trifoliatum Gaertn. // Rauvolfia trifoliata (Gaertn.) Baill.

Family:
Rubiaceae
Approval state:
Approved
Number of articles retrieved:
816
Number of processed references:
7
Compositions
#1: yohimbine in roots #2: reserpine, reserpinine, perakine yohimbine, isorauhimbine, and ajmaline in roots #3: N-methylajmaline, N-methylisoajmaline, 3-hydroxysarpagine, yohimbinic acid, isorauhimbinic acid in roots #4: ajmaline in roots #5: ajmalicine in roots #6: reserpine in roots #7: Reserpine #8: reserpine in roots #9: ajmalicine in roots #10: Ajmalicine and derivatives #11: Ajmaline and derivatives #12: Yohimbine and derivatives #13: Reserpine and derivatives #14: Serpentine and derivatives
Endpoint Studies
#1: sedative effect, mortality
Genotoxicity
Composition #1: Klyushnichenko, V. E., Yakimov, S. A., Tuzova, T. P., Syagailo, Ya. V., Kuzovkina, I. N., Wulfson, A. N., Miroshnikov, A. I. Determination of indole alkaloids from R. serpentina and R. vomitoria by high-performance liquid chromatography and high-performance thin-layer chromatography. journal of chromatography a, 1995, vol. 704, no. 2, p. 357–62. .
Composition #2: Itoh, A., Kumashiro, T., Yamaguchi, M., Nagakura, N., Mizushina, Y., Nishi, T., Tanahashi, T. Indole alkaloids and other constituents of Rauwolfia serpentina. journal of natural products, 2005, vol. 68, no. 6, p. 848–852. DOI: 10.1021/np058007n. [DOI link]
Composition #3: Itoh, A., Kumashiro, T., Yamaguchi, M., Nagakura, N., Mizushina, Y., Nishi, T., Tanahashi, T. Indole alkaloids and other constituents of Rauwolfia serpentina. journal of natural products, 2005, vol. 68, no. 6, p. 848–852. DOI: 10.1021/np058007n. [DOI link]
Composition #4: Gupta, Madan Mohan., Srivastava, Alpana., Tripathi, Arvind Kumar., Misra, Himanshu., Verma, Ram Kishore. Use of HPTLC, HPLC, and densitometry for qualitative separation of indole alkaloids from Rauvolfia serpentina roots . jpc-journal of planar chromatography-modern tlc, 2006, vol. 19, no. 110, p. 282–287. DOI: 10.1556/JPC.19.2006.4.5. [DOI link]
Composition #5: Gupta, Madan Mohan., Srivastava, Alpana., Tripathi, Arvind Kumar., Misra, Himanshu., Verma, Ram Kishore. Use of HPTLC, HPLC, and densitometry for qualitative separation of indole alkaloids from Rauvolfia serpentina roots . jpc-journal of planar chromatography-modern tlc, 2006, vol. 19, no. 110, p. 282–287. DOI: 10.1556/JPC.19.2006.4.5. [DOI link]
Composition #6: Gupta, Madan Mohan., Srivastava, Alpana., Tripathi, Arvind Kumar., Misra, Himanshu., Verma, Ram Kishore. Use of HPTLC, HPLC, and densitometry for qualitative separation of indole alkaloids from Rauvolfia serpentina roots . jpc-journal of planar chromatography-modern tlc, 2006, vol. 19, no. 110, p. 282–287. DOI: 10.1556/JPC.19.2006.4.5. [DOI link]
Composition #7: Abdelfatah, Sara A. A., Efferth, Thomas. Cytotoxicity of the indole alkaloid reserpine from Rauwoffia serpentina against drug-resistant tumor cells . phytomedicine, 2015, vol. 22, no. 2, p. 308–318. DOI: 10.1016/j.phymed.2015.01.002. [DOI link]
Composition #8: Pandey, Devendra Kumar., Radha., Dey, Abhijit. A validated and densitometric HPTLC method for the simultaneous quantification of reserpine and ajmalicine in Rauvolfia serpentina and Rauvolfia tetraphylla . revista brasileira de farmacognosia-brazilian journal of pharmacognosy, 2016, vol. 26, no. 5, p. 553–557. DOI: 10.1016/j.bjp.2016.04.002. [DOI link]
Composition #9: Pandey, Devendra Kumar., Radha., Dey, Abhijit. A validated and densitometric HPTLC method for the simultaneous quantification of reserpine and ajmalicine in Rauvolfia serpentina and Rauvolfia tetraphylla . revista brasileira de farmacognosia-brazilian journal of pharmacognosy, 2016, vol. 26, no. 5, p. 553–557. DOI: 10.1016/j.bjp.2016.04.002. [DOI link]
Composition #10: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Kumar, Brijesh. Structural characterization of monoterpene indole alkaloids in ethanolic extracts of Rauwolfia species by liquid chromatography with quadrupole time-of-flight mass spectrometry . journal of pharmaceutical analysis, 2016, vol. 6, no. 6, p. 363–373. DOI: 10.1016/j.jpha.2016.04.008. [DOI link]
Composition #11: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Kumar, Brijesh. Structural characterization of monoterpene indole alkaloids in ethanolic extracts of Rauwolfia species by liquid chromatography with quadrupole time-of-flight mass spectrometry . journal of pharmaceutical analysis, 2016, vol. 6, no. 6, p. 363–373. DOI: 10.1016/j.jpha.2016.04.008. [DOI link]
Composition #12: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Kumar, Brijesh. Structural characterization of monoterpene indole alkaloids in ethanolic extracts of Rauwolfia species by liquid chromatography with quadrupole time-of-flight mass spectrometry . journal of pharmaceutical analysis, 2016, vol. 6, no. 6, p. 363–373. DOI: 10.1016/j.jpha.2016.04.008. [DOI link]
Composition #13: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Kumar, Brijesh. Structural characterization of monoterpene indole alkaloids in ethanolic extracts of Rauwolfia species by liquid chromatography with quadrupole time-of-flight mass spectrometry . journal of pharmaceutical analysis, 2016, vol. 6, no. 6, p. 363–373. DOI: 10.1016/j.jpha.2016.04.008. [DOI link]
Composition #14: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Kumar, Brijesh. Structural characterization of monoterpene indole alkaloids in ethanolic extracts of Rauwolfia species by liquid chromatography with quadrupole time-of-flight mass spectrometry . journal of pharmaceutical analysis, 2016, vol. 6, no. 6, p. 363–373. DOI: 10.1016/j.jpha.2016.04.008. [DOI link]
Endpoint study #1: Azmi, Muhammad Bilal., Qureshi, Shamim A. Methanolic Root Extract of Rauwolfia serpentina Improves the Glucose Tolerance in Wister Mice . journal of food and drug analysis, 2012, vol. 20, no. 2, p. 484–488. DOI: 10.6227/jfda.2012200208. [DOI link]