EFSA Compendium of Botanicals

Draft - work in progress

Putranjiva roxburghii Wall.

Family:: Putranjivaceae
Approval state:: Approved
Number of articles retrieved:: 137
Number of processed references:: 6

Compositions

#1: isothiocyanates (butyl- and isopropyl-) in seed kernel #2: Phenylethyl isothiocyanate in seed kernel #3: alkaloids in seeds #4: saponins in seeds #5: tannins in bark #6: Triterpene saponins in leaves #7: Lectins in fruit

Endpoint Studies

#1: The purified inhibitor from the seeds inhibited bovine trypsin in 1:1 molar ratio

Genotoxicity

Composition #1: Puntambekar, S.V. Mustard oils and mustard oil glucosides occurring in the seed kernels of Putranjiva roxburghii Wall.. proceedings of the indian academy of sciences - section a, 1950, vol. 32, no. 2, p. 114–122. DOI: 10.1007/BF03171376. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

steam distillation
Substance:

Isothiocyanates (RF-00010827-PAR)
Additional substance description:

butyl- and isopropyl-
Analytical method code:

Traditional analytical techniques (wet chemical tests) (F003A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

isothiocyanates (butyl- and isopropyl-) in seed kernel

Composition #2: Puntambekar, S.V. Mustard oils and mustard oil glucosides occurring in the seed kernels of Putranjiva roxburghii Wall.. proceedings of the indian academy of sciences - section a, 1950, vol. 32, no. 2, p. 114–122. DOI: 10.1007/BF03171376. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

steam distillation
Substance:

Phenethyl Isothiocyanate (RF-00011468-PAR)
Analytical method code:

Traditional analytical techniques (wet chemical tests) (F003A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Phenylethyl isothiocyanate in seed kernel

Composition #3: Raghavendra, H.L., Prashith Kekuda, T.R., Valleesha, N.C., Sudharshan, S.J., Chinmaya, A. Screening for cytotoxic activity of methanol extract of Putranjiva roxburghii Wall (Euphorbiaceae) seeds. pharmacognosy journal, 2010, vol. 2, no. 10, p. 335–337. DOI: 10.1016/S0975-3575(10)80105-1. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids in seeds

Composition #4: Raghavendra, H.L., Prashith Kekuda, T.R., Valleesha, N.C., Sudharshan, S.J., Chinmaya, A. Screening for cytotoxic activity of methanol extract of Putranjiva roxburghii Wall (Euphorbiaceae) seeds. pharmacognosy journal, 2010, vol. 2, no. 10, p. 335–337. DOI: 10.1016/S0975-3575(10)80105-1. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins in seeds

Composition #5: Abhimanyu, K.K., Ravindra, C.S., Avanapu, R.S. Pharmacognostic and physico-chemical investigation of bark of Putranjiva roxburghii Wall (Euphorbiaceae). international journal of pharma and bio sciences, 2015, vol. 6, no. 3, p. P530–P538. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol or water
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tannins in bark

Composition #6: Kumar, Ashish., Chowdhury, Somenath Roy., Chakrabarti, Tulika., Majumdar, Hemanta K., Jha, Tarun., Mukhopadhyay, Sibabrata. A New Ellagic Acid Glycoside and DNA Topoisomerase IB Inhibitory Activity of Saponins from Putranjiva roxburghii . natural product communications, 2014, vol. 9, no. 5, p. 675–677. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Additional substance description:

putranoside- A and D putranoside-A methyl ester
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Triterpene saponins in leaves

Composition #7: Gulzar, Haseena., Gul, Jaweria., Hassan, Gul. PROTEIN PROFILES OF PHYTOAGGLUTININS FROM INDIGENOUS SPECIES OF EUPHORBIACEAE, LEGUMINOSAE AND MORACEAE FROM PAKISTAN . pakistan journal of botany, 2015, vol. 47, p. 119–126. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Additional extraction description:

NaCl
Substance:

Lectins (RF-00000439-ORG)
Analytical method code:

Agglutination tests (Agg.) (F082A)
Analytical method - additional description:

erytrocyte agglutination test
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lectins in fruit

Endpoint study #1: Chaudhary, Navneet S., Shee, Chandan., Islam, Asimul., Ahmad, Faizan., Yernool, Dinesh., Kumar, Pravindra., Sharma, Ashwani K. Purification and characterization of a trypsin inhibitor from Putranjiva roxburghii seeds . phytochemistry, 2008, vol. 69, no. 11, p. 2120–2126. DOI: 10.1016/j.phytochem.2008.05.002. [DOI link]

Study relevance:

Human health
Plant part:

Seed (as part-nature) (A066P)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

distilled water
Type of toxicological test:

other (CHD008TT)
Endpoint measured:

Enzyme inhibition (CHD067EP)
Concentration unit:

Mole (G119A)
Effect concentration:

1
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Pancreas (TT024A)
Effect description:

trypsin inhibitor
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

The purified inhibitor from the seeds inhibited bovine trypsin in 1:1 molar ratio