EFSA
ecomole
vscht
  2. Pueraria candollei Benth. var. mirifica (Airy Shaw & Suvat.) Niyomdham // Pueraria mirifica Airy Shaw & Suvat.

Pueraria candollei Benth. var. mirifica (Airy Shaw & Suvat.) Niyomdham // Pueraria mirifica Airy Shaw & Suvat.

Family:
Fabaceae
Approval state:
Approved
Number of articles retrieved:
248
Number of processed references:
9
Compositions
#1: isoflavonoides in tuber, tuber cortex and tuber without cortex #2: miroestrol in tuber, tuber cortex and tuber without cortex #3: deoxymiroestrol in tuber, tuber cortex and tuber without cortex #4: daidzin in tubers #5: daidzein in tubers #6: genistin in tubers #7: genistein in tubers #8: total isoflavones in tubers #9: puerarin in tubers #10: kwakhurin in roots #11: deoxymiroestrol in roots #12: miroestrol in roots #13: Deoxymiroestrol in tubers
Endpoint Studies
#1: histopathological changes in liver and kidneys after dosing with aqueous extract of the tubers #2: reduced body weight, affected hematopoiesis after dosing with aqueous and ethanolic extract of tubers #3: effect on male mice - reduced weights of epididymides, seminal vehicle; reduced sperm motility and viability after dosing with aqueous extract of tuber #4: adverse effect on reproduction of female mice - changes in hypothalamic - pituitary-ovarian-uterine axis #5: Lower body weight and higher organ weights of uterus, vagina, and kidneys and histopathological changes in ovariectomized rats dosed with roots
Genotoxicity
#1: Aqueous extract of the tubers was mutagenic in the micronucleus test in rats #2: Gentoxic effect in micronucleus test in vivo in rats of aqueous and ethanolic extract of tubers
Composition #1: Yusakul, Gorawit., Putalun, Waraporn., Udomsin, Orapin., Juengwatanatrakul, Thaweesak., Chaichantipyuth, Chaiyo. Comparative analysis of the chemical constituents of two varieties of Pueraria candollei. fitoterapia, 2011, vol. 82, no. 2, p. 203–207. .
Composition #2: Yusakul, Gorawit., Putalun, Waraporn., Udomsin, Orapin., Juengwatanatrakul, Thaweesak., Chaichantipyuth, Chaiyo. Comparative analysis of the chemical constituents of two varieties of Pueraria candollei. fitoterapia, 2011, vol. 82, no. 2, p. 203–207. .
Composition #3: Yusakul, Gorawit., Putalun, Waraporn., Udomsin, Orapin., Juengwatanatrakul, Thaweesak., Chaichantipyuth, Chaiyo. Comparative analysis of the chemical constituents of two varieties of Pueraria candollei. fitoterapia, 2011, vol. 82, no. 2, p. 203–207. .
Composition #4: Urasopon, Nontakorn., Hamada, Yuzuru., Asaoka, Kazuo., Poungmali, Ubon., Malaivijitnond, Suchinda. Isoflavone content of rodent diets and its estrogenic effect on vaginal cornification in Pueraria mirifica-treated rats . scienceasia, 2008, vol. 34, no. 4, p. 371–376. DOI: 10.2306/scienceasia1513-1874.2008.34.371. [DOI link]
Composition #5: Urasopon, Nontakorn., Hamada, Yuzuru., Asaoka, Kazuo., Poungmali, Ubon., Malaivijitnond, Suchinda. Isoflavone content of rodent diets and its estrogenic effect on vaginal cornification in Pueraria mirifica-treated rats . scienceasia, 2008, vol. 34, no. 4, p. 371–376. DOI: 10.2306/scienceasia1513-1874.2008.34.371. [DOI link]
Composition #6: Urasopon, Nontakorn., Hamada, Yuzuru., Asaoka, Kazuo., Poungmali, Ubon., Malaivijitnond, Suchinda. Isoflavone content of rodent diets and its estrogenic effect on vaginal cornification in Pueraria mirifica-treated rats . scienceasia, 2008, vol. 34, no. 4, p. 371–376. DOI: 10.2306/scienceasia1513-1874.2008.34.371. [DOI link]
Composition #7: Urasopon, Nontakorn., Hamada, Yuzuru., Asaoka, Kazuo., Poungmali, Ubon., Malaivijitnond, Suchinda. Isoflavone content of rodent diets and its estrogenic effect on vaginal cornification in Pueraria mirifica-treated rats . scienceasia, 2008, vol. 34, no. 4, p. 371–376. DOI: 10.2306/scienceasia1513-1874.2008.34.371. [DOI link]
Composition #8: Urasopon, Nontakorn., Hamada, Yuzuru., Asaoka, Kazuo., Poungmali, Ubon., Malaivijitnond, Suchinda. Isoflavone content of rodent diets and its estrogenic effect on vaginal cornification in Pueraria mirifica-treated rats . scienceasia, 2008, vol. 34, no. 4, p. 371–376. DOI: 10.2306/scienceasia1513-1874.2008.34.371. [DOI link]
Composition #9: Urasopon, Nontakorn., Hamada, Yuzuru., Asaoka, Kazuo., Poungmali, Ubon., Malaivijitnond, Suchinda. Isoflavone content of rodent diets and its estrogenic effect on vaginal cornification in Pueraria mirifica-treated rats . scienceasia, 2008, vol. 34, no. 4, p. 371–376. DOI: 10.2306/scienceasia1513-1874.2008.34.371. [DOI link]
Composition #10: Shimokawa, Satoko., Kumamoto, Takuya., Ishikawa, Tsutomu., Takashi, Miho., Higuchi, Yoshihiro., Chaichantipyuth, Chaiyo., Chansakaow, Sunee. Quantitative analysis of miroestrol and kwakhurin for standardisation of Thai miracle herb "Kwao Keur' (Pueraria mirifica) and establishment of simple isolation procedure for highly estrogenic miroestrol and deoxymiroestrol . natural product research, 2013, vol. 27, no. 4-5, p. 371–378. DOI: 10.1080/14786419.2012.695370. [DOI link]
Composition #11: Shimokawa, Satoko., Kumamoto, Takuya., Ishikawa, Tsutomu., Takashi, Miho., Higuchi, Yoshihiro., Chaichantipyuth, Chaiyo., Chansakaow, Sunee. Quantitative analysis of miroestrol and kwakhurin for standardisation of Thai miracle herb "Kwao Keur' (Pueraria mirifica) and establishment of simple isolation procedure for highly estrogenic miroestrol and deoxymiroestrol . natural product research, 2013, vol. 27, no. 4-5, p. 371–378. DOI: 10.1080/14786419.2012.695370. [DOI link]
Composition #12: Shimokawa, Satoko., Kumamoto, Takuya., Ishikawa, Tsutomu., Takashi, Miho., Higuchi, Yoshihiro., Chaichantipyuth, Chaiyo., Chansakaow, Sunee. Quantitative analysis of miroestrol and kwakhurin for standardisation of Thai miracle herb "Kwao Keur' (Pueraria mirifica) and establishment of simple isolation procedure for highly estrogenic miroestrol and deoxymiroestrol . natural product research, 2013, vol. 27, no. 4-5, p. 371–378. DOI: 10.1080/14786419.2012.695370. [DOI link]
Composition #13: Yusakul, Gorawit., Udomsin, Orapin., Juengwatanatrakul, Thaweesak., Tanaka, Hiroyuki., Chaichantipyuth, Chaiyo., Putalun, Waraporn. Highly selective and sensitive determination of deoxymiroestrol using a polyclonal antibody-based enzyme-linked immunosorbent assay . talanta, 2013, vol. 114, p. 73–78. DOI: 10.1016/j.talanta.2013.04.011. [DOI link]
Endpoint study #1: Sanchanta, P., Saenphet, K., Saenphet, S., Aritajat, S., Wongsawad, C., Brovelli, E., Chansakaow, S., Farias, D., Hongratanaworakit, T., Omary, MB., Vejabhikul, S. Toxicological study of aqueous and ethanolic extracts from Pueraria mirifica Airy Shaw & Suvatabandhu on male rats . wocmap iii: quality, efficacy, safety, processing and trade in maps, 2005, no. 679, p. 165–171. .
Endpoint study #2: Sanchanta, P., Saenphet, K., Saenphet, S., Aritajat, S., Wongsawad, C., Brovelli, E., Chansakaow, S., Farias, D., Hongratanaworakit, T., Omary, MB., Vejabhikul, S. Toxicological study of aqueous and ethanolic extracts from Pueraria mirifica Airy Shaw & Suvatabandhu on male rats . wocmap iii: quality, efficacy, safety, processing and trade in maps, 2005, no. 679, p. 165–171. .
Endpoint study #3: Jaroenporn, Sukanya., Malaivijitnond, Suchinda., Wattanasirmkit, Kingkaew., Trisomboon, Hataitip., Watanabe, Gen., Taya, Kazuyoshi., Cherdshewasart, Wichai. Effects of Pueraria mirifica, an herb containing phytoestrogens, on reproductive organs and fertility of adult male mice . endocrine, 2006, vol. 30, no. 1, p. 93–101. DOI: 10.1385/ENDO:30:1:93. [DOI link]
Endpoint study #4: Jaroenporn, Sukanya., Malaivijitnond, Suchinda., Wattanasirmkit, Kingkaew., Watanabe, Gen., Taya, Kazuyoshi., Cherdshewasart, Wichai. Assessment of fertility and reproductive toxicity in adult female mice after long-term exposure to Pueraria mirifica herb . journal of reproduction and development, 2007, vol. 53, no. 5, p. 995–1005. DOI: 10.1262/jrd.18151. [DOI link]
Endpoint study #5: Gomuttapong, Sarawoot., Pewphong, Rangsima., Choeisiri, Sucha., Jaroenporn, Sukanya., Malaivijitnond, Suchinda. Testing of the estrogenic activity and toxicity of Stephania venosa herb in ovariectomized rats . toxicology mechanisms and methods, 2012, vol. 22, no. 6, p. 445–457. DOI: 10.3109/15376516.2012.668573. [DOI link]
Genotox #1: Saenphet, K., Kantaoop, P., Saenphet, S., Aritajat, S. Mutagenicity of Pueraria mirifica Airy Shaw & Suvatabandhu and antimutagenicity of Thunbergia laurifolia Linn. . the southeast asian journal of tropical medicine and public health, 2005, vol. 36 Suppl 4, p. 238–41. .
Genotox #2: Sanchanta, P., Saenphet, K., Saenphet, S., Aritajat, S., Wongsawad, C., Brovelli, E., Chansakaow, S., Farias, D., Hongratanaworakit, T., Omary, MB., Vejabhikul, S. Toxicological study of aqueous and ethanolic extracts from Pueraria mirifica Airy Shaw & Suvatabandhu on male rats . wocmap iii: quality, efficacy, safety, processing and trade in maps, 2005, no. 679, p. 165–171. .