EFSA Compendium of Botanicals

Draft - work in progress

Prunella vulgaris L.

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 2000
Number of processed references:: 3

Compositions

#1: 3,4-dihydroxybenzoic acid #2: triterpenoid saponins in spikes #3: esculetin in aerial part #4: umbelliferone in aerial part

Endpoint Studies

Genotoxicity

Composition #1: Zhou, Y.-M., Tang, J., Xiong, S.-H., Li, Y.-M., Lin, Y., Xia, B.-H., Lin, L.-M., Liao, D.-F. Polar Chemical Constituents from Prunella vulgaris L. and Their Anti-human Breast Tumor Activities. chinese pharmaceutical journal, 2017, vol. 52, no. 5, p. 362–366. DOI: 10.11669/cpj.2017.05.006. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

3,4-Dihydroxybenzoic acid (RF-00008853-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

3,4-dihydroxybenzoic acid

Composition #2: Gu, Xiao-Jie., Li, You-Bin., Li, Ping., Qian, Shi-Hui., Zhang, Jian-Feng. Triterpenoid saponins from the spikes of Prunella vulgaris. helvetica chimica acta, 2007, vol. 90, no. 1, p. 72–78. DOI: 10.1002/hlca.200790023. [DOI link]

Language:

English (en)
Plant part:

Flowering top (as part-nature) (A166H)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 50%
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR, HR-ESI-MS spectroscopic analysis
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

triterpenoid saponins in spikes

Composition #3: Hu, Xiaoli., Cui, Shuya., Chen, Xingguo., Hu, Zhide. CE with Field-Enhanced Stacking for Rapid and Sensitive Determination of Umbelliferone, Rutin and Aesculetin in Prunella vulgaris . chromatographia, 2009, vol. 70, no. 11-12, p. 1733–1736. DOI: 10.1365/s10337-009-1373-8. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Esculetin (RF-00003667-PAR)
Additional substance description:

syn for aesculetin
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Result unit:

Milligram/gram (G060A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0123
Internal remarks:

esculetin in aerial part

Composition #4: Hu, Xiaoli., Cui, Shuya., Chen, Xingguo., Hu, Zhide. CE with Field-Enhanced Stacking for Rapid and Sensitive Determination of Umbelliferone, Rutin and Aesculetin in Prunella vulgaris . chromatographia, 2009, vol. 70, no. 11-12, p. 1733–1736. DOI: 10.1365/s10337-009-1373-8. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

umbelliferone (RF-00004096-PAR)
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Result unit:

Milligram/gram (G060A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.985
Internal remarks:

umbelliferone in aerial part