EFSA Compendium of Botanicals

Draft - work in progress

Premna serratifolia L. // Premna integrifolia L. // Premna obtusifolia R.Br.

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 170
Number of processed references:: 6

Compositions

#1: Tannins in roots #2: Alkaloids in roots #3: Cardiac glycosides (a digoxin like substance) in roots #4: alkaloids in leaves #5: tannins in leaves #6: Clerodendrin-A lignan in roots #7: 4-hydroxybenzaldehyde in leaves #8: alkaloids in stem bark and stem wood

Endpoint Studies

Genotoxicity

Composition #1: Mali, Prashant Y., Bhadane, Vijay V. Comparative account of screening of bioactive ingredients of Premna integrifolia Linn. with special reference to root by using various solvents. journal of pharmacy research, 2010, vol. 3, no. 7, p. 1677–1679. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

three different solvents tested: water, petroleum ether and chloroform: methanol. Tannins not present in petroleum ether extract
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins in roots

Composition #2: Mali, Prashant Y., Bhadane, Vijay V. Comparative account of screening of bioactive ingredients of Premna integrifolia Linn. with special reference to root by using various solvents. journal of pharmacy research, 2010, vol. 3, no. 7, p. 1677–1679. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

three different solvents tested: water, petroleum ether and chloroform: methanol and all positive for alkaloids
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in roots

Composition #3: Bose, Lekshmi V., George, K. V., Iyer, R. Shankar., Deepa, T. D. Identification of novel cardiac principle in the roots of Premna serratifolia L.. journal of pharmacy research, 2012, vol. 5, no. 6, p. 3261–3264. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

cardiac glycosides (RF-00010823-PAR)
Additional substance description:

A digoxin like substance detected
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Analytical method - additional description:

Phytochemical scrrening
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardiac glycosides (a digoxin like substance) in roots

Composition #4: Biradi, Mahesh., Hullatti, Kirankumar. Screening of Indian medicinal plants for cytotoxic activity by brine shrimp lethality (BSL) assay and evaluation of their total phenolic content. drug development and therapeutics, 2014, vol. 5, no. 2, p. 139–144. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids in leaves

Composition #5: Biradi, Mahesh., Hullatti, Kirankumar. Screening of Indian medicinal plants for cytotoxic activity by brine shrimp lethality (BSL) assay and evaluation of their total phenolic content. drug development and therapeutics, 2014, vol. 5, no. 2, p. 139–144. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tannins in leaves

Composition #6: Gokani, Rina H., Kapadia, Nayana S., Shah, Mamta B. Comparative pharmacognostic study of Clerodendrum phlomidis and Premna integrifolia . journal of natural remedies, 2008, vol. 8, no. 2, p. 222–231. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

Clerodendrin-A
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPTLC
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.073
Internal remarks:

Clerodendrin-A lignan in roots

Composition #7: Nguyen Thi Bich Hang., Pham Thanh Ky., Chau Van Minh., Nguyen Xuan Cuong., Nguyen Phoung Thao., Phan Van Kiem. Study on the chemical constituents of Premna integrifolia L.. natural product communications, 2008, vol. 3, no. 9, p. 1449–1452. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

4-Hydroxybenzaldehyde (RF-00001976-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

4-hydroxybenzaldehyde in leaves

Composition #8: Rajendran, Rekha., Suseela, L., Sundaram, Meenakshi R., Basha, Saleem N. Cardiac stimulant activity of bark and wood of Premna serratifolia. bangladesh journal of pharmacology, 2008, vol. 3, no. 2, p. 107–113. DOI: 10.3329/bjp.v3i2.952. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol (stem bark and stem wood)
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids in stem bark and stem wood