EFSA
ecomole
vscht
  2. Polygala tenuifolia Willd.

Polygala tenuifolia Willd.

Family:
Polygalaceae
Approval state:
Approved
Number of articles retrieved:
3424
Number of processed references:
7
Compositions
#1: beta-carboline-alkaloids (harman (2.8×10-​3%), norharman (1.7×10-​3%), 1-​carbomethoxy-​β-​carboline (1.3×10-​3%), 1-​carboethoxy-​β-​carboline (1.4×10-​3%) and perlolyrine (3.3×10-​3%)), #2: Harmane in unspecified part #3: Harmol in unspecified part #4: Norharman in unspecified part #5: Harmalol in unspecified part #6: tetrahydrocolumbamine in unspecified part. #7: Beta-carboline alkaloids (1-carbobutoxy- beta-carboline, N9-formylharman, 1- carboethoxy-beta-carboline, 1-carbomethoxy-beta-carboline, perlolyrine, harman and norharman) in tubers #8: Onjisaponins, senegins, polygala saponin XXXII in radix #9: Polygalasaponins in roots #10: saponins in root bark
Endpoint Studies
#1: lethal dose in mice LD 50
Genotoxicity
Composition #1: Park, Man Ki., Park, Jeong Hill., Kim, Bao Yuan., Kim, Jong Moon., Liem, Kyung Jin., Han, Byung Hoon. Analysis of alkaloids in Polygala tenuifolia by HPLC. analytical science & technology, 1993, vol. 6, no. 3, p. 255–9. .
Composition #2: Tsuchiya, Hironori., Hayashi, Hideaki., Sato, Masaru., Shimizu, Hiroshi., Iinuma, Munekazu. Quantitative analysis of all types of β-carboline alkaloids in medicinal plants and dried edible plants by high performance liquid chromatography with selective fluorometric detection. phytochemical analysis, 1999, vol. 10, no. 5, p. 247–253. .
Composition #3: Tsuchiya, Hironori., Hayashi, Hideaki., Sato, Masaru., Shimizu, Hiroshi., Iinuma, Munekazu. Quantitative analysis of all types of β-carboline alkaloids in medicinal plants and dried edible plants by high performance liquid chromatography with selective fluorometric detection. phytochemical analysis, 1999, vol. 10, no. 5, p. 247–253. .
Composition #4: Tsuchiya, Hironori., Hayashi, Hideaki., Sato, Masaru., Shimizu, Hiroshi., Iinuma, Munekazu. Quantitative analysis of all types of β-carboline alkaloids in medicinal plants and dried edible plants by high performance liquid chromatography with selective fluorometric detection. phytochemical analysis, 1999, vol. 10, no. 5, p. 247–253. .
Composition #5: Tsuchiya, Hironori., Hayashi, Hideaki., Sato, Masaru., Shimizu, Hiroshi., Iinuma, Munekazu. Quantitative analysis of all types of β-carboline alkaloids in medicinal plants and dried edible plants by high performance liquid chromatography with selective fluorometric detection. phytochemical analysis, 1999, vol. 10, no. 5, p. 247–253. .
Composition #6: Shen, X. L., Witt, M. R., Dekermendjian, K., Nielsen, M. Isolation and identification of tetrahydro-columbamine as a dopamine receptor ligand from Polygala tenuifolia Willd . yaoxue xuebao, 1994, vol. 29, no. 12, p. 887–890. .
Composition #7: Han, B.H., Park, J.H., Park, M.H., Han, Y.N. β-Carboline alkaloids of Polygala tenuifolia. archives of pharmacal research, 1985, vol. 8, no. 4, p. 243–247. DOI: 10.1007/BF02856497. [DOI link]
Composition #8: Liu, Jiangyun., Yang, Xuedong., He, Jiuming., Xia, Min., Xu, Lizhen., Yang, Shilin. Structure analysis of triterpene saponins in Polygala tenuifolia by electrospray ionization ion trap multiple-stage mass spectrometry . journal of mass spectrometry, 2007, vol. 42, no. 7, p. 861–873. DOI: 10.1002/jms.1210. [DOI link]
Composition #9: Yao, Yi., Jia, Min., Wu, Jian-Guo., Zhang, Hong., Sun, Lian-Na., Chen, Wan-Sheng., Rahman, Khalid. Anxiolytic and sedative-hypnotic activities of polygalasaponins from Polygala tenuifolia in mice . pharmaceutical biology, 2010, vol. 48, no. 7, p. 801–807. DOI: 10.3109/13880200903280042. [DOI link]
Composition #10: Dou, Fang., Xi, Miaomiao., Wang, Junxian., Tian, Xiangrong., Hong, Liangjian., Tang, Haifeng., Wen, Aidong. alpha-Glucosidase and alpha-amylase inhibitory activities of saponins from traditional Chinese medicines in the treatment of diabetes mellitus . pharmazie, 2013, vol. 68, no. 4, p. 300–304. DOI: 10.1691/ph.2013.2753. [DOI link]
Endpoint study #1: Yao, Yi., Jia, Min., Wu, Jian-Guo., Zhang, Hong., Sun, Lian-Na., Chen, Wan-Sheng., Rahman, Khalid. Anxiolytic and sedative-hypnotic activities of polygalasaponins from Polygala tenuifolia in mice . pharmaceutical biology, 2010, vol. 48, no. 7, p. 801–807. DOI: 10.3109/13880200903280042. [DOI link]