EFSA
ecomole
vscht
  2. Podophyllum peltatum L.

Podophyllum peltatum L.

Family:
Berberidaceae
Approval state:
Approved
Number of articles retrieved:
433
Number of processed references:
10
Compositions
#1: picropodophyllin in the rhizomes #2: deoxypodophyllotoxin in the resin #3: podophyllotoxin in rhizomes #4: podophyllotoxin in leaves #5: podophyllotoxin glucoside in rhizomes #6: podophyllotoxin glucoside in leaves #7: beta-peltatin in leaves #8: podophyllotoxin in leaves #9: alpha-peltatin in leaves #10: total lignans in leaves #11: beta-peltatin in leaves #12: total lignans in leaves #13: alpha-peltatin in leaves #14: podophyllotoxin in leaves #15: alpha-peltatin in resin #16: beta-peltatin in resin #17: lignans podophyllotoxin-Beta-D-glucoside and 4’-demethylpodophyllotoxin in resin #18: podophyllotoxin in resin
Endpoint Studies
#1: dose-related fatty change of the liver, atrophy and degenerative changes of the intestinal epithelial linings and testicular seminiferous tubules upon the administration og 5 mg/kg podophyllotoxin for 7 days #2: gastro and neurotoxicity in humans #3: cortical atrophy with ventricular dilation, peripheral neuropathy, spasticity in all 4 limbs and neck retroflexed, epileptic states, depression of respiratory system, respiratory alkalosis and hypocalcemia, hypotonia, hyporeflexia, spastic quadriparesis #4: Nausea and vomiting in humans
Genotoxicity
Composition #1: Press, J., Brun, R. The structure of podophyllotoxin and the peltatins. helvetica chimica acta, 1954, vol. 37, p. 1543–4. .
Composition #2: Santavy, Frantisek. Isolation of deoxypodophyllotoxin from resina podophylli from Podophyllum peltatum. chemicke listy pro vedu a prumysl, 1957, vol. 51, p. 2148–9. .
Composition #3: Canel, C., Dayan, FE., Ganzera, M., Khan, IA., Rimando, A., Burandt, CL., Moraes, RM. High yield of podophyllotoxin from leaves of Podophyllum peltatum by in situ conversion of podophyllotoxin 4 O-beta-D-glucopyranoside . planta medica, 2001, vol. 67, no. 1, p. 97–99. DOI: 10.1055/s-2001-10636. [DOI link]
Composition #4: Canel, C., Dayan, FE., Ganzera, M., Khan, IA., Rimando, A., Burandt, CL., Moraes, RM. High yield of podophyllotoxin from leaves of Podophyllum peltatum by in situ conversion of podophyllotoxin 4 O-beta-D-glucopyranoside . planta medica, 2001, vol. 67, no. 1, p. 97–99. DOI: 10.1055/s-2001-10636. [DOI link]
Composition #5: Canel, C., Dayan, FE., Ganzera, M., Khan, IA., Rimando, A., Burandt, CL., Moraes, RM. High yield of podophyllotoxin from leaves of Podophyllum peltatum by in situ conversion of podophyllotoxin 4 O-beta-D-glucopyranoside . planta medica, 2001, vol. 67, no. 1, p. 97–99. DOI: 10.1055/s-2001-10636. [DOI link]
Composition #6: Canel, C., Dayan, FE., Ganzera, M., Khan, IA., Rimando, A., Burandt, CL., Moraes, RM. High yield of podophyllotoxin from leaves of Podophyllum peltatum by in situ conversion of podophyllotoxin 4 O-beta-D-glucopyranoside . planta medica, 2001, vol. 67, no. 1, p. 97–99. DOI: 10.1055/s-2001-10636. [DOI link]
Composition #7: Cushman, KE., Maqbool, M., Lata, H., Bedir, E., Khan, KA., Moraes, RM. Podophyllotoxin content and yield of American mayapple leaves in sun and shade . hortscience, 2005, vol. 40, no. 1, p. 60–63. .
Composition #8: Cushman, KE., Maqbool, M., Lata, H., Bedir, E., Khan, KA., Moraes, RM. Podophyllotoxin content and yield of American mayapple leaves in sun and shade . hortscience, 2005, vol. 40, no. 1, p. 60–63. .
Composition #9: Cushman, KE., Maqbool, M., Lata, H., Bedir, E., Khan, KA., Moraes, RM. Podophyllotoxin content and yield of American mayapple leaves in sun and shade . hortscience, 2005, vol. 40, no. 1, p. 60–63. .
Composition #10: Cushman, KE., Maqbool, M., Lata, H., Bedir, E., Khan, KA., Moraes, RM. Podophyllotoxin content and yield of American mayapple leaves in sun and shade . hortscience, 2005, vol. 40, no. 1, p. 60–63. .
Composition #11: Cushman, Kent E., Moraes, Rita M., Gerard, Patrick D., Bedir, Ebru., Silva, Bladimiro., Khan, Ikhlas A. Frequency and timing of leaf removal affect growth and podophyllotoxin content of Podophyllum peltatum in full sun . planta medica, 2006, vol. 72, no. 9, p. 824–829. DOI: 10.1055/s-2006-946675. [DOI link]
Composition #12: Cushman, Kent E., Moraes, Rita M., Gerard, Patrick D., Bedir, Ebru., Silva, Bladimiro., Khan, Ikhlas A. Frequency and timing of leaf removal affect growth and podophyllotoxin content of Podophyllum peltatum in full sun . planta medica, 2006, vol. 72, no. 9, p. 824–829. DOI: 10.1055/s-2006-946675. [DOI link]
Composition #13: Cushman, Kent E., Moraes, Rita M., Gerard, Patrick D., Bedir, Ebru., Silva, Bladimiro., Khan, Ikhlas A. Frequency and timing of leaf removal affect growth and podophyllotoxin content of Podophyllum peltatum in full sun . planta medica, 2006, vol. 72, no. 9, p. 824–829. DOI: 10.1055/s-2006-946675. [DOI link]
Composition #14: Cushman, Kent E., Moraes, Rita M., Gerard, Patrick D., Bedir, Ebru., Silva, Bladimiro., Khan, Ikhlas A. Frequency and timing of leaf removal affect growth and podophyllotoxin content of Podophyllum peltatum in full sun . planta medica, 2006, vol. 72, no. 9, p. 824–829. DOI: 10.1055/s-2006-946675. [DOI link]
Composition #15: Lim, CK. Analysis of aryltetrahydronaphthalene lignans and their glucoside conjugates in podophyllin resin by high-performance liquid chromatography . journal of chromatography a, 1996, vol. 722, no. 1-2, p. 267–271. DOI: 10.1016/0021-9673(95)00433-5. [DOI link]
Composition #16: Lim, CK. Analysis of aryltetrahydronaphthalene lignans and their glucoside conjugates in podophyllin resin by high-performance liquid chromatography . journal of chromatography a, 1996, vol. 722, no. 1-2, p. 267–271. DOI: 10.1016/0021-9673(95)00433-5. [DOI link]
Composition #17: Lim, CK. Analysis of aryltetrahydronaphthalene lignans and their glucoside conjugates in podophyllin resin by high-performance liquid chromatography . journal of chromatography a, 1996, vol. 722, no. 1-2, p. 267–271. DOI: 10.1016/0021-9673(95)00433-5. [DOI link]
Composition #18: Lim, CK. Analysis of aryltetrahydronaphthalene lignans and their glucoside conjugates in podophyllin resin by high-performance liquid chromatography . journal of chromatography a, 1996, vol. 722, no. 1-2, p. 267–271. DOI: 10.1016/0021-9673(95)00433-5. [DOI link]
Endpoint study #1: Chang, L W., Yang, C M., Chen, C F., Deng, J F. Experimental podophyllotoxin (bajiaolian) poisoning: II. Effects on the liver, intestine, kidney, pancreas and testis. . biomedical and environmental sciences : bes, 1992, vol. 5, no. 4, p. 293–302. .
Endpoint study #2: Chu, CC., Huang, CC., Chu, NS. Sensory neuropathy due to Bajiaolian (podophyllotoxin) intoxication. european neurology, 2000, vol. 44, no. 2, p. 121–123. DOI: 10.1159/000008210. [DOI link]
Endpoint study #3: Kumar, Manish., Shanmugham, Arumugasamy., Prabha, Sivaprakasam., Adhisivam, Bethou., Narayanan, Parameswaran., Biswal, Niranjan. Permanent Neurological Sequelae Following Accidental Podophyllin Ingestion . journal of child neurology, 2012, vol. 27, no. 2, p. 209–210. DOI: 10.1177/0883073811415682. [DOI link]
Endpoint study #4: Frasca, T., Brett, AS., Yoo, SD. Mandrake toxicity - A case of mistaken identity. archives of internal medicine, 1997, vol. 157, no. 17, p. 2007–2009. DOI: 10.1001/archinte.157.17.2007. [DOI link]