EFSA Compendium of Botanicals

Draft - work in progress

Podophyllum hexandrum Royle // Podophyllum emodi Wall. ex Hook.f. & Thomson // Sinopodophyllum hexandrum (Royle) T.S.Ying

Family:: Berberidaceae
Approval state:: Approved
Number of articles retrieved:: 826
Number of processed references:: 2

Compositions

#1: Lignans (many related to podophyllotoxin) in roots #2: Epiisopodophyllotoxin in roots #3: Hyroxymethylfurfural in roots #4: Deoxypodophyllotoxin in roots #5: 16-keto-hydrosolasodine in roots #6: Podophyllotoxin acetate in roots #7: Podophyllotoxin in roots

Endpoint Studies

Genotoxicity

Composition #1: Sun, Yan-Jun., Li, Zhan-Lin., Chen, Hong., Liu, Xiao-Qiu., Zhou, Wei., Hua, Hui-Ming. Three new cytotoxic aryltetralin lignans from Sinopodophyllum emodi. bioorganic & medicinal chemistry letters, 2011, vol. 21, no. 12, p. 3794–3797. DOI: 10.1016/j.bmcl.2011.04.036. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

sinolignan A; sinolignan B; and a variety of derivatives of podophyllotoxin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans (many related to podophyllotoxin) in roots

Composition #2: Dar, Sabzar Ahmad., Yousuf, Abdul Rehman., Balkhi, Masood-ul-Hassan., Ganai, Bashir Ahmad., Tantry, Mudasir., Bhat, Farooz Ahmad. Podophyllum hexandrum ameliorates endosulfan-induced genotoxicity and mutagenicity in freshwater cyprinid fish crucian carp . pharmaceutical biology, 2017, vol. 55, no. 1, p. 173–183. DOI: 10.1080/13880209.2016.1233568. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol and ethyl acetate (separately, range of concentrations accounts for the two extractions)
Substance:

podophyllotoxin (RF-00004001-PAR)
Additional substance description:

epiisopodophyllotoxin
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.47-21.13
Internal remarks:

Epiisopodophyllotoxin in roots

Composition #3: Dar, Sabzar Ahmad., Yousuf, Abdul Rehman., Balkhi, Masood-ul-Hassan., Ganai, Bashir Ahmad., Tantry, Mudasir., Bhat, Farooz Ahmad. Podophyllum hexandrum ameliorates endosulfan-induced genotoxicity and mutagenicity in freshwater cyprinid fish crucian carp . pharmaceutical biology, 2017, vol. 55, no. 1, p. 173–183. DOI: 10.1080/13880209.2016.1233568. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Hydroxymethylfurfural (RF-00000379-ORG)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

28.65
Internal remarks:

Hyroxymethylfurfural in roots

Composition #4: Dar, Sabzar Ahmad., Yousuf, Abdul Rehman., Balkhi, Masood-ul-Hassan., Ganai, Bashir Ahmad., Tantry, Mudasir., Bhat, Farooz Ahmad. Podophyllum hexandrum ameliorates endosulfan-induced genotoxicity and mutagenicity in freshwater cyprinid fish crucian carp . pharmaceutical biology, 2017, vol. 55, no. 1, p. 173–183. DOI: 10.1080/13880209.2016.1233568. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol and ethyl acetate (separately - range of concentration accounts for the two different extractions)
Substance:

deoxypodophyllotoxin (RF-00003769-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.83-24.22
Internal remarks:

Deoxypodophyllotoxin in roots

Composition #5: Dar, Sabzar Ahmad., Yousuf, Abdul Rehman., Balkhi, Masood-ul-Hassan., Ganai, Bashir Ahmad., Tantry, Mudasir., Bhat, Farooz Ahmad. Podophyllum hexandrum ameliorates endosulfan-induced genotoxicity and mutagenicity in freshwater cyprinid fish crucian carp . pharmaceutical biology, 2017, vol. 55, no. 1, p. 173–183. DOI: 10.1080/13880209.2016.1233568. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate
Substance:

solasodine (RF-00003583-PAR)
Additional substance description:

related compound: "16-keto-hydrosolasodine"
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.10
Internal remarks:

16-keto-hydrosolasodine in roots

Composition #6: Dar, Sabzar Ahmad., Yousuf, Abdul Rehman., Balkhi, Masood-ul-Hassan., Ganai, Bashir Ahmad., Tantry, Mudasir., Bhat, Farooz Ahmad. Podophyllum hexandrum ameliorates endosulfan-induced genotoxicity and mutagenicity in freshwater cyprinid fish crucian carp . pharmaceutical biology, 2017, vol. 55, no. 1, p. 173–183. DOI: 10.1080/13880209.2016.1233568. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate
Substance:

podophyllotoxin acetate (RF-00011090-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

21.13
Internal remarks:

Podophyllotoxin acetate in roots

Composition #7: Dar, Sabzar Ahmad., Yousuf, Abdul Rehman., Balkhi, Masood-ul-Hassan., Ganai, Bashir Ahmad., Tantry, Mudasir., Bhat, Farooz Ahmad. Podophyllum hexandrum ameliorates endosulfan-induced genotoxicity and mutagenicity in freshwater cyprinid fish crucian carp . pharmaceutical biology, 2017, vol. 55, no. 1, p. 173–183. DOI: 10.1080/13880209.2016.1233568. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol and ethyl acetate (separately, range of concentrations accounts for the two different extractions)
Substance:

podophyllotoxin (RF-00004001-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.92-18.91
Internal remarks:

Podophyllotoxin in roots