EFSA Compendium of Botanicals

Draft - work in progress

Plectranthus barbatus Andrews // Coleus barbatus (Andrews) Benth ex. G.Don

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 395
Number of processed references:: 6

Compositions

#1: alfa-thujone, aerial parts, GC-MS #2: cyclobubatusin, barbatusin and 7β-acetyl-12-deacetoxycyclobutatusin in leaves #3: Labdane diterpenes (42 labdane derivatives) #4: forskolin, roots #5: abietanes (dehydroabietane, 5,6-didehydro-7-hydroxy-taxodone, taxodione, 20-deoxocarnosol, 6 alpha, 11,12,-trihydroxy-7 beta, 20-epoxy-8,11,13-abietatriene), aerial parts

Endpoint Studies

#1: preimplantion loss, number of skeletal variation, reduced number of ossification centres

Genotoxicity

Composition #1: Muhayimana, Ancilla., Chalchat, Jean-Claude., Garry, Raymond-Philippe. Chemical composition of essential oils of some medicinal plants from Rwanda. journal of essential oil research, 1998, vol. 10, no. 3, p. 251–259. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

alpha-thujone (RF-00003676-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.4-1.6
Internal remarks:

alfa-thujone, aerial parts, GC-MS

Composition #2: de Albuquerque, Roberto L., Kentopff, Marta R., Machado, Maria Iracema L., Silva, Maria Goretti V., Matos, Francisco Jose de A., Morais, Selene M., Braz Filho, Raimundo. Abietane diterpenoids isolation from Plectranthus barbatus. quimica nova, 2007, vol. 30, no. 8, p. 1882–1886. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water/choroform
Substance:

Diterpenes Diterpenes (RF-00004378-PAR)
Additional substance description:

cyclobubatusin, barbatusin and 7β-acetyl-12-deacetoxycyclobutatusin
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

NMR, MS, IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cyclobubatusin, barbatusin and 7β-acetyl-12-deacetoxycyclobutatusin in leaves

Composition #3: Alasbahi, Rawiya H., Melzig, Matthias F. Plectranthus barbatus: A Review of Phytochemistry, Ethnobotanical Uses and Pharmacology - Part 1 . planta medica, 2010, vol. 76, no. 7, p. 653–661. DOI: 10.1055/s-0029-1240898. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

labdane diterpenes (RF-00004392-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Labdane diterpenes (42 labdane derivatives)

Composition #4: Alasbahi, R. H., Melzig, M. F. Forskolin and derivatives as tools for studying the role of cAMP. pharmazie, 2012, vol. 67, no. 1, p. 5–13. DOI: 10.1691/ph.2012.1642. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

forskolin (RF-00004295-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

forskolin, roots

Composition #5: Mothana, Ramzi A., Al-Said, Mansour S., Al-Musayeib, Nawal M., El Gamal, Ali A., Al-Massarani, Shaza M., Al-Rehaily, Adnan J., Abdulkader, Majed., Maes, Louis. In Vitro Antiprotozoal Activity of Abietane Diterpenoids Isolated from Plectranthus barbatus Andr. . international journal of molecular sciences, 2014, vol. 15, no. 5, p. 8360–8371. DOI: 10.3390/ijms15058360. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Diterpenes Diterpenes (RF-00004378-PAR)
Additional substance description:

abietanes: dehydroabietane, 5,6-didehydro-7-hydroxy-taxodone, taxodione, 20-deoxocarnosol, 6 alpha, 11,12,-trihydroxy-7 beta, 20-epoxy-8,11,13-abietatriene.
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

abietanes (dehydroabietane, 5,6-didehydro-7-hydroxy-taxodone, taxodione, 20-deoxocarnosol, 6 alpha, 11,12,-trihydroxy-7 beta, 20-epoxy-8,11,13-abietatriene), aerial parts

Endpoint study #1: Verissimo, Luiz Fernando., Bacchi, Andre D., Zaminelli, Tiago., de Paula, Gustavo Henrique O., Moreira, Estefania G. Herbs of interest to the Brazilian Federal Government: female reproductive and developmental toxicity studies . revista brasileira de farmacognosia-brazilian journal of pharmacognosy, 2011, vol. 21, no. 6, p. 1163–1171. .

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

alcohol
Type of toxicological test:

not reported (CHD015TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Number of organisms dosed:

10
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

880
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

Bone (TT054A)
Effect description:

preimplantion loss, number of skeletal variation, reduced number of ossification centres
Effect or parameter linked to the endpoint:

not reported (CHD030BE)
Internal remarks:

preimplantion loss, number of skeletal variation, reduced number of ossification centres