EFSA Compendium of Botanicals

Draft - work in progress

Pistacia lentiscus L.

Family:: Anacardiaceae
Approval state:: Approved
Number of articles retrieved:: 1567
Number of processed references:: 6

Compositions

#1: saponins, aerial parts, phytochemical screening #2: tannins, aerial parts, phytochemical screening #3: digallic acid, fruit #4: cineol, leaves, gc-ms #5: myrcene, leaves, gc-ms #6: myrcene

Endpoint Studies

#1: mortality, mouse, extract

Genotoxicity

#1: ethanolic extract moderately mutagenic #2: digallic acid in concentration 10 ug/assay induced genotoxicity

Composition #1: Villar, A., Sanz, M.J., Paya, M. Hypotensive effect of pistacia lentiscus l. pharmaceutical biology, 1987, vol. 25, no. 1, p. 1–3. DOI: 10.3109/13880208709060902. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water/methanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins, aerial parts, phytochemical screening

Composition #2: Villar, A., Sanz, M.J., Paya, M. Hypotensive effect of pistacia lentiscus l. pharmaceutical biology, 1987, vol. 25, no. 1, p. 1–3. DOI: 10.3109/13880208709060902. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water/methanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tannins, aerial parts, phytochemical screening

Composition #3: Bhouri, Wissem., Derbel, Safa., Skandrani, Ines., Boubaker, Jihed., Bouhlel, Ines., Sghaier, Mohamed B., Kilani, Soumaya., Mariotte, Anne M., Dijoux-Franca, Marie G., Ghedira, Kamel., Chekir-Ghedira, Leila. Study of genotoxic, antigenotoxic and antioxidant activities of the digallic acid isolated from Pistacia lentiscus fruits . toxicology in vitro, 2010, vol. 24, no. 2, p. 509–515. DOI: 10.1016/j.tiv.2009.06.024. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate-methanol
Substance:

gallic acid (RF-00003821-PAR)
Additional substance description:

digallic acid
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

digallic acid, fruit

Composition #4: Bachrouch, Olfa., Jemaa, Jouda Mediouni-Ben., Talou, Thierry., Marzouk, Brahim., Abderraba, Manef. Fumigant toxicity of Pistacia lentiscus essential oil against Tribolium castaneum and Lasioderma serricorne . bulletin of insectology, 2010, vol. 63, no. 1, p. 129–135. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.04
Internal remarks:

cineol, leaves, gc-ms

Composition #5: Bachrouch, Olfa., Jemaa, Jouda Mediouni-Ben., Talou, Thierry., Marzouk, Brahim., Abderraba, Manef. Fumigant toxicity of Pistacia lentiscus essential oil against Tribolium castaneum and Lasioderma serricorne . bulletin of insectology, 2010, vol. 63, no. 1, p. 129–135. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.12
Internal remarks:

myrcene, leaves, gc-ms

Composition #6: Buriani, Alessandro., Fortinguerra, Stefano., Sorrenti, Vincenzo., Dall'Acqua, Stefano., Innocenti, Gabbriella., Montopoli, Monica., Gabbia, Daniela., Carrara, Maria. Human Adenocarcinoma Cell Line Sensitivity to Essential Oil Phytocomplexes from Pistacia Species: a Multivariate Approach . molecules, 2017, vol. 22, no. 8 . DOI: 10.3390/molecules22081336. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.67-57.59
Internal remarks:

myrcene

Endpoint study #1: Boukeloua, A., Belkhiri, A., Djerrou, Z., Bahri, L., Boulebda, N., Pacha, Y. Hamdi. ACUTE TOXICITY OF OPUNTIA FICUS INDICA AND PISTACIA LENTISCUS SEED OILS IN MICE . african journal of traditional complementary and alternative medicines, 2012, vol. 9, no. 4, p. 607–611. DOI: 10.4314/ajtcam.v9i4.19. [DOI link]

Study relevance:

Human health
Plant part:

Seed (as part-nature) (A066P)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

hexane
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male/Female
Unit of exposure duration:

single (food/feed) (G203A)
Number of organisms dosed:

10
Endpoint measured:

Dose producing lethality in 50% of experimental organisms (CHD024EP)
Concentration unit:

millilitre per kilogram (G253A)
Effect concentration:

37
Critical effect:

SYSTEMIC (TOX01A)
Effect description:

mortality, behavoiral pertubation, gitation, diarrhea, sedation
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

mortality, mouse, extract

Genotox #1: Alkofahi, A., Al-Khalil, S. Mutagenic and toxic activity of some Jordanian medicinal plants. international journal of pharmacognosy, 1995, vol. 33, no. 1, p. 61–64. .

Study category:

Mutagenicity
Type of toxicological test:

bacterial reverse mutation assay (CHD028TT)
Method type:

in vitro
Tested organism:

Salmonella typhimurium (as organism) (A0CPZ)
Strain of test organism:

TA 98 (CHD029ST)
Endpoint measured:

gene mutation
Is genotoxic:

Ambiguous
Remarks on genotox study:

moderately mutagenic
Internal remarks:

ethanolic extract moderately mutagenic
Internal ID:

eid=2-s2.0-0028927680

Genotox #2: Bhouri, Wissem., Derbel, Safa., Skandrani, Ines., Boubaker, Jihed., Bouhlel, Ines., Sghaier, Mohamed B., Kilani, Soumaya., Mariotte, Anne M., Dijoux-Franca, Marie G., Ghedira, Kamel., Chekir-Ghedira, Leila. Study of genotoxic, antigenotoxic and antioxidant activities of the digallic acid isolated from Pistacia lentiscus fruits . toxicology in vitro, 2010, vol. 24, no. 2, p. 509–515. DOI: 10.1016/j.tiv.2009.06.024. [DOI link]

Study category:

Genotoxicity
Type of toxicological test:

bacterial gene mutation assay (CHD027TT)
Method type:

in vitro
Tested organism:

Escherichia coli (as organism) (A0CQA)
Strain of test organism:

PQ37 (CHD078ST)
Exogenous metabolic activation applied:

with and without
Is genotoxic:

Ambiguous
Remarks on genotox study:

digallic acid in concentration 10 ug/assay induced genotoxicity
Internal remarks:

digallic acid in concentration 10 ug/assay induced genotoxicity
Internal ID:

WOS:000275991700022