EFSA
ecomole
vscht
  2. Piper betle L.

Piper betle L.

Family:
Piperaceae
Approval state:
Approved
Number of articles retrieved:
1179
Number of processed references:
7
Compositions
#1: Eugenol in leaves #2: Hydroxychavicol in leaves #3: P-coumaric acid in leaves #4: Piperlonguminine in stem #5: Cepharadione A in leaves #6: Piperine in stem #7: Tannins in leaves #8: Cardiac glycosides in leaves #9: Saponins in leaves #10: Piperine, dehydropipernonaline, piperdardine, piperolein-B, guineensine in stem #11: Syringaresinol-O-beta-D-glucopyranoside, pinoresinol in stem #12: Safrole in leaves #13: Myrcene in leaves #14: Eugenol in leaves #15: Hydroxychavicol in inflorescence
Endpoint Studies
#1: Alpha-glucosidase inhibition, water extract from leaves #2: Alpha-glucosidase inhibition, ethanol extract from leaves
Genotoxicity
#1: Gene mutation induced by hydroxychavicol #2: Chromosome aberration induced by hydroxychavicol
Composition #1: Srividya, Srinivasan., Pillai, Subramanian Iyyam., Subramaniana, Sorimuthu Pillai. Isolation and characterization of major phytochemicals from the leaves of Piper betle. Linn. international journal of pharmacy (hyderabad, india), 2015, vol. 5, no. 4, p. 1215–1233. .
Composition #2: Srividya, Srinivasan., Pillai, Subramanian Iyyam., Subramaniana, Sorimuthu Pillai. Isolation and characterization of major phytochemicals from the leaves of Piper betle. Linn. international journal of pharmacy (hyderabad, india), 2015, vol. 5, no. 4, p. 1215–1233. .
Composition #3: Srividya, Srinivasan., Pillai, Subramanian Iyyam., Subramaniana, Sorimuthu Pillai. Isolation and characterization of major phytochemicals from the leaves of Piper betle. Linn. international journal of pharmacy (hyderabad, india), 2015, vol. 5, no. 4, p. 1215–1233. .
Composition #4: Parmar, V.S., Jain, S.C., Gupta, S., Talwar, S., Rajwanshi, V.K., Kumar, R., Azim, A., Malhotra, S., Kumar, N., Jain, R., Sharma, N.K., Tyagi, O.D., Lawrie, S.J., Errington, W., Howarth, O.W., Olsen, C.E., Singh, S.K., Wengel, J. Polyphenols and alkaloids from piper species. phytochemistry, 1998, vol. 49, no. 4, p. 1069–1078. DOI: 10.1016/S0031-9422(98)00208-8. [DOI link]
Composition #5: Parmar, V.S., Jain, S.C., Gupta, S., Talwar, S., Rajwanshi, V.K., Kumar, R., Azim, A., Malhotra, S., Kumar, N., Jain, R., Sharma, N.K., Tyagi, O.D., Lawrie, S.J., Errington, W., Howarth, O.W., Olsen, C.E., Singh, S.K., Wengel, J. Polyphenols and alkaloids from piper species. phytochemistry, 1998, vol. 49, no. 4, p. 1069–1078. DOI: 10.1016/S0031-9422(98)00208-8. [DOI link]
Composition #6: Parmar, V.S., Jain, S.C., Gupta, S., Talwar, S., Rajwanshi, V.K., Kumar, R., Azim, A., Malhotra, S., Kumar, N., Jain, R., Sharma, N.K., Tyagi, O.D., Lawrie, S.J., Errington, W., Howarth, O.W., Olsen, C.E., Singh, S.K., Wengel, J. Polyphenols and alkaloids from piper species. phytochemistry, 1998, vol. 49, no. 4, p. 1069–1078. DOI: 10.1016/S0031-9422(98)00208-8. [DOI link]
Composition #7: De Vera, J.S., De Castro, M.E.G., Dulay, R.M.R. Phytochemical constituents and teratogenic effect of lyophilized extracts of Bixa orellana L. (Achuete) and Piper betle L. (Ikmo) leaves in Danio rerio Embryos. der pharma chemica, 2016, vol. 8, no. 18, p. 432–437. .
Composition #8: De Vera, J.S., De Castro, M.E.G., Dulay, R.M.R. Phytochemical constituents and teratogenic effect of lyophilized extracts of Bixa orellana L. (Achuete) and Piper betle L. (Ikmo) leaves in Danio rerio Embryos. der pharma chemica, 2016, vol. 8, no. 18, p. 432–437. .
Composition #9: De Vera, J.S., De Castro, M.E.G., Dulay, R.M.R. Phytochemical constituents and teratogenic effect of lyophilized extracts of Bixa orellana L. (Achuete) and Piper betle L. (Ikmo) leaves in Danio rerio Embryos. der pharma chemica, 2016, vol. 8, no. 18, p. 432–437. .
Composition #10: Huang, Xiangzhong., Yin, Yan., Huang, Wenquan., Sun, Kuizong., Cheng, Chunmei., Bai, Lian., Dai, Yun. Alkaloids and lignans from stems of Piper betle .. zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica, 2010, vol. 35, no. 17, p. 2285–8. .
Composition #11: Huang, Xiangzhong., Yin, Yan., Huang, Wenquan., Sun, Kuizong., Cheng, Chunmei., Bai, Lian., Dai, Yun. Alkaloids and lignans from stems of Piper betle .. zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica, 2010, vol. 35, no. 17, p. 2285–8. .
Composition #12: Mohottalage, Susantha., Tabacchi, Raffaele., Guerin, Patrick M. Components from Sri Lankan Piper betle L. leaf oil and their analogues showing toxicity against the housefly, Musca domestica . flavour and fragrance journal, 2007, vol. 22, no. 2, p. 130–138. DOI: 10.1002/ffj.1770. [DOI link]
Composition #13: Mohottalage, Susantha., Tabacchi, Raffaele., Guerin, Patrick M. Components from Sri Lankan Piper betle L. leaf oil and their analogues showing toxicity against the housefly, Musca domestica . flavour and fragrance journal, 2007, vol. 22, no. 2, p. 130–138. DOI: 10.1002/ffj.1770. [DOI link]
Composition #14: Mohottalage, Susantha., Tabacchi, Raffaele., Guerin, Patrick M. Components from Sri Lankan Piper betle L. leaf oil and their analogues showing toxicity against the housefly, Musca domestica . flavour and fragrance journal, 2007, vol. 22, no. 2, p. 130–138. DOI: 10.1002/ffj.1770. [DOI link]
Composition #15: LeeChen, SF., Chen, CL., Ho, LY., Hsu, PC., Chang, JT., Sun, CM., Chi, CW., Liu, TY. Role of oxidative DNA damage in hydroxychavicol-induced genotoxicity. mutagenesis, 1996, vol. 11, no. 5, p. 519–523. DOI: 10.1093/mutage/11.5.519. [DOI link]
Endpoint study #1: Oliveira, Andreia P., Ferreira, Joana G., Riboira, Sofia., Andrade, Paula B., Valentao, Patricia. Bioactive Natural Products from Piper betle L. Leaves and their alpha-Glucosidase Inhibitory Potential . records of natural products, 2016, vol. 10, no. 6, p. 771–781. .
Endpoint study #2: Oliveira, Andreia P., Ferreira, Joana G., Riboira, Sofia., Andrade, Paula B., Valentao, Patricia. Bioactive Natural Products from Piper betle L. Leaves and their alpha-Glucosidase Inhibitory Potential . records of natural products, 2016, vol. 10, no. 6, p. 771–781. .
Genotox #1: LeeChen, SF., Chen, CL., Ho, LY., Hsu, PC., Chang, JT., Sun, CM., Chi, CW., Liu, TY. Role of oxidative DNA damage in hydroxychavicol-induced genotoxicity. mutagenesis, 1996, vol. 11, no. 5, p. 519–523. DOI: 10.1093/mutage/11.5.519. [DOI link]
Genotox #2: LeeChen, SF., Chen, CL., Ho, LY., Hsu, PC., Chang, JT., Sun, CM., Chi, CW., Liu, TY. Role of oxidative DNA damage in hydroxychavicol-induced genotoxicity. mutagenesis, 1996, vol. 11, no. 5, p. 519–523. DOI: 10.1093/mutage/11.5.519. [DOI link]