Draft - work in progress
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- Pokeweed (as plant) // Phytolacca americana L.
Pokeweed (as plant) // Phytolacca americana L.
- Family:
- Phytolaccaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 1484
- Number of processed references:
- 7
Composition #1: Wang, Zhuju., Cheng, Ming., Yuan, Sitong. Quantitative determination of phytolaccatoxin in Phytolacca americana roots by TLC-densitometry. zhongguo zhongyao zazhi, 1990, vol. 15, no. 9, p. 533–5. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol
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Substance:
phytolaccatoxin (RF-00003996-PAR)
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Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Phytolaccatoxin in roots
Composition #2: Otsuka, Rafaela Denise., Lago, Joao Henrique Ghilardi., Rossi, Lucia., Galduroz, Jose Carlos Fernandes., Rodrigues, Eliana. Psychoactive plants described in a Brazilian literary work and their chemical compounds. central nervous system agents in medicinal chemistry, 2010, vol. 10, no. 3, p. 218–237. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Additional extraction description:
not specified
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Substance:
Saponins (RF-00004333-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
saponins in the roots
Composition #3: Kim, YO., Johnson, JD., Lee, EJ. Phytotoxic effects and chemical analysis of leaf extracts from three Phytolaccaceae species in South Korea . journal of chemical ecology, 2005, vol. 31, no. 5, p. 1175–1186. DOI: 10.1007/s10886-005-4255-z.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
distilled water
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Substance:
gallic acid (RF-00003821-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
gallic acid in leaves
Composition #4: Kim, YO., Johnson, JD., Lee, EJ. Phytotoxic effects and chemical analysis of leaf extracts from three Phytolaccaceae species in South Korea . journal of chemical ecology, 2005, vol. 31, no. 5, p. 1175–1186. DOI: 10.1007/s10886-005-4255-z.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
distilled water
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Substance:
3,4-Dihydroxybenzoic acid (RF-00008853-PAR)
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Additional substance description:
syn for protocatechuic acid
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
protocatechuic acid in leaves
Composition #5: Kim, YO., Johnson, JD., Lee, EJ. Phytotoxic effects and chemical analysis of leaf extracts from three Phytolaccaceae species in South Korea . journal of chemical ecology, 2005, vol. 31, no. 5, p. 1175–1186. DOI: 10.1007/s10886-005-4255-z.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
distilled water
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Substance:
3-Hydroxybenzoic acid (RF-00008852-PAR)
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Additional substance description:
syn for m-hydroxybenzoic acid
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
m-hydroxybenzoic acid in leaves
Composition #6: Kim, YO., Johnson, JD., Lee, EJ. Phytotoxic effects and chemical analysis of leaf extracts from three Phytolaccaceae species in South Korea . journal of chemical ecology, 2005, vol. 31, no. 5, p. 1175–1186. DOI: 10.1007/s10886-005-4255-z.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
distilled water
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Substance:
p-coumaric acid (RF-00010717-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
p-coumaric acid in leaves
Composition #7: Petersen, Dan D. Common plant toxicology: A comparison of national and Southwest Ohio data trends on plant poisonings in the 21st century . toxicology and applied pharmacology, 2011, vol. 254, no. 2, p. 148–153. DOI: 10.1016/j.taap.2010.10.022.
[
DOI link]
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Additional extraction description:
unspecified
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Substance:
Alkaloids (RF-00004360-PAR)
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Analytical method - additional description:
unspecified
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
alkaloids (in many plant part)
Composition #8: Petersen, Dan D. Common plant toxicology: A comparison of national and Southwest Ohio data trends on plant poisonings in the 21st century . toxicology and applied pharmacology, 2011, vol. 254, no. 2, p. 148–153. DOI: 10.1016/j.taap.2010.10.022.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Additional extraction description:
unspecified
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Substance:
saponin glycosides saponin glycosides (RF-00004318-PAR)
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Analytical method - additional description:
unspecified
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
saponin glycosides in leaves
Endpoint study
#1: Smith, GW., Constable, PD. Suspected pokeweed toxicity in a boer goat. veterinary and human toxicology, 2002, vol. 44, no. 6, p. 351–353. .
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Study relevance:
Animal (target species) health
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Plant part:
Unspecified (A07XD)
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Goat (as animal) (A057P)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
acute bloody diarrhea
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Effect or parameter linked to the endpoint:
other (CHD003BE)
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Internal remarks:
diarrhea in goats
Endpoint study
#2: Valle, Emanuela., Vergnano, Diana., Nebbia, Carlo. Suspected Pokeweed (Phytolacca americana L.) Poisoning as the Cause of Progressive Cachexia in a Shetland Pony . journal of equine veterinary science, 2016, vol. 42, p. 82–87. DOI: 10.1016/j.jevs.2016.04.013.
[
DOI link]
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Study relevance:
Animal (target species) health
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Plant part:
Live plants (as part-nature) (A0BA0)
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Horse (as animal) (A0B9Z)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
SYSTEMIC (TOX01A)
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Target tissue:
Digestive (TT002A)
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Effect description:
a cachectic state with progressive apathy, diarrhea, and difficulties in feed prehension, a slow rate of ingestion, small hyperemic areas on the buccal mucosa, signs of gastritis, a decrease in the plasma total protein, anemia, and depressive attitude
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Effect or parameter linked to the endpoint:
behaviour (CHD001BE)
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Internal remarks:
case report in ponny:progressive cachexia
Endpoint study
#3: GRIESS, D., ENJALBERT, F., RECH, J. DIAGNOSIS OF FOOD-POISONING BY PHYTOLACCA-DECANDRA L IN HORSES. revue de medecine veterinaire, 1994, vol. 145, no. 2, p. 133–139. .
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Study relevance:
Animal (target species) health
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Horse (as animal) (A0B9Z)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Number of organisms dosed:
4
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Endpoint measured:
Dose not reported (CHD066EP)
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Effect description:
4 horses were poisoned, 2 died
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Effect or parameter linked to the endpoint:
mortality (CHD010BE)
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Internal remarks:
Mortality in horses