EFSA
ecomole
vscht
  2. Phyllanthus amarus Schumach. & Thonn.

Phyllanthus amarus Schumach. & Thonn.

Family:
Phyllanthaceae
Approval state:
Approved
Number of articles retrieved:
1068
Number of processed references:
6
Compositions
#1: anthraquinones in leaves (phytochemical screen) #2: "Tannis" (tannins) in leaves (phytochemical screen) #3: alkaloids in leaves (phytochemical screen) #4: cardenolides in leaves (phytochemical screen) #5: "sapinins" (saponins) in leaves (phytochemical screen) #6: Tannins in aerial parts (phytochem. screening) #7: Alkaloids in aerial parts (phytochem. screening) #8: Anthraquinones in aerial parts (phytochem. screening) #9: Naphthoquinones in aerial parts (phytochem. screening) #10: saponins in aerial parts (phytochem. screening) #11: nirtetralin, niranthrin, phyllanthin, phyltetralin
Endpoint Studies
#1: decresed level of PCV, RBC, WBC and Hb #2: increased level of total protein, albumin and AST #3: sperm abnormalities at tested extract after 5 weeks #4: sperm abnormalities at tested extract after 10 weeks #5: increased number of white blood cells and lymphocyte count #6: significant pathological changes in the liver, kidney and testis #7: alpha-glucosidase inhibition
Genotoxicity
#1: increasing frequency of micronucleated polychromatic erythrocytes
Composition #1: Peters, D. E., Omeodu, S. I. Effect of ethanolic leave extract of phyllantus amarus on carbon tetrachloride (CCl4) induced hepatotoxicity in albino rats. journal of applied sciences and environmental management, 2015, vol. 19, no. 4, p. 803–808. .
Composition #2: Peters, D. E., Omeodu, S. I. Effect of ethanolic leave extract of phyllantus amarus on carbon tetrachloride (CCl4) induced hepatotoxicity in albino rats. journal of applied sciences and environmental management, 2015, vol. 19, no. 4, p. 803–808. .
Composition #3: Peters, D. E., Omeodu, S. I. Effect of ethanolic leave extract of phyllantus amarus on carbon tetrachloride (CCl4) induced hepatotoxicity in albino rats. journal of applied sciences and environmental management, 2015, vol. 19, no. 4, p. 803–808. .
Composition #4: Peters, D. E., Omeodu, S. I. Effect of ethanolic leave extract of phyllantus amarus on carbon tetrachloride (CCl4) induced hepatotoxicity in albino rats. journal of applied sciences and environmental management, 2015, vol. 19, no. 4, p. 803–808. .
Composition #5: Peters, D. E., Omeodu, S. I. Effect of ethanolic leave extract of phyllantus amarus on carbon tetrachloride (CCl4) induced hepatotoxicity in albino rats. journal of applied sciences and environmental management, 2015, vol. 19, no. 4, p. 803–808. .
Composition #6: Nascimento, J. E., Melo, A. F. M., Lima e Silva, T. C., Veras Filho, J., Santos, E. M., Albuquerque, U. P., Amorim, E. L. C. Phytochemical screening and toxicological bioassay with brine shrimp larvae (Artemia salina Leach) of three medicinal species of the genus Phyllanthus (Phyllanthaceae) . revista de ciencias farmaceuticas basica e aplicada, 2008, vol. 29, no. 2, p. 143–148. .
Composition #7: Nascimento, J. E., Melo, A. F. M., Lima e Silva, T. C., Veras Filho, J., Santos, E. M., Albuquerque, U. P., Amorim, E. L. C. Phytochemical screening and toxicological bioassay with brine shrimp larvae (Artemia salina Leach) of three medicinal species of the genus Phyllanthus (Phyllanthaceae) . revista de ciencias farmaceuticas basica e aplicada, 2008, vol. 29, no. 2, p. 143–148. .
Composition #8: Nascimento, J. E., Melo, A. F. M., Lima e Silva, T. C., Veras Filho, J., Santos, E. M., Albuquerque, U. P., Amorim, E. L. C. Phytochemical screening and toxicological bioassay with brine shrimp larvae (Artemia salina Leach) of three medicinal species of the genus Phyllanthus (Phyllanthaceae) . revista de ciencias farmaceuticas basica e aplicada, 2008, vol. 29, no. 2, p. 143–148. .
Composition #9: Nascimento, J. E., Melo, A. F. M., Lima e Silva, T. C., Veras Filho, J., Santos, E. M., Albuquerque, U. P., Amorim, E. L. C. Phytochemical screening and toxicological bioassay with brine shrimp larvae (Artemia salina Leach) of three medicinal species of the genus Phyllanthus (Phyllanthaceae) . revista de ciencias farmaceuticas basica e aplicada, 2008, vol. 29, no. 2, p. 143–148. .
Composition #10: Nascimento, J. E., Melo, A. F. M., Lima e Silva, T. C., Veras Filho, J., Santos, E. M., Albuquerque, U. P., Amorim, E. L. C. Phytochemical screening and toxicological bioassay with brine shrimp larvae (Artemia salina Leach) of three medicinal species of the genus Phyllanthus (Phyllanthaceae) . revista de ciencias farmaceuticas basica e aplicada, 2008, vol. 29, no. 2, p. 143–148. .
Composition #11: Rajendra Prasad, N., Muthusamy, G., Shanmugam, M., Ambudkar, S.V. South asian medicinal compounds as modulators of resistance to chemotherapy and radiotherapy. cancers, 2016, vol. 8, no. 3 . DOI: 10.3390/cancers8030032. [DOI link]
Endpoint study #1: Adedapo, Adeolu Alex., Abatan, Matthew Oluwole., Olorunsogo, Olufunso Olabode. Effects of some plants of the spurge family on haematological and biochemical parameters in rats . veterinarski arhiv, 2007, vol. 77, no. 1, p. 29–38. .
Endpoint study #2: Adedapo, Adeolu Alex., Abatan, Matthew Oluwole., Olorunsogo, Olufunso Olabode. Effects of some plants of the spurge family on haematological and biochemical parameters in rats . veterinarski arhiv, 2007, vol. 77, no. 1, p. 29–38. .
Endpoint study #3: Bakare, A.A., Oguntolu, G.O., Adedokun, L.A., Amao, A.A., Oyeyemi, I.T., Alimba, C.G., Alabi, O.A. In vivo evaluation of genetic and systemic toxicity of aqueous extracts of phyllanthus amarus in mice and rats. international journal of toxicological and pharmacological research, 2015, vol. 7, no. 4 . .
Endpoint study #4: Bakare, A.A., Oguntolu, G.O., Adedokun, L.A., Amao, A.A., Oyeyemi, I.T., Alimba, C.G., Alabi, O.A. In vivo evaluation of genetic and systemic toxicity of aqueous extracts of phyllanthus amarus in mice and rats. international journal of toxicological and pharmacological research, 2015, vol. 7, no. 4 . .
Endpoint study #5: Bakare, A.A., Oguntolu, G.O., Adedokun, L.A., Amao, A.A., Oyeyemi, I.T., Alimba, C.G., Alabi, O.A. In vivo evaluation of genetic and systemic toxicity of aqueous extracts of phyllanthus amarus in mice and rats. international journal of toxicological and pharmacological research, 2015, vol. 7, no. 4 . .
Endpoint study #6: Bakare, A.A., Oguntolu, G.O., Adedokun, L.A., Amao, A.A., Oyeyemi, I.T., Alimba, C.G., Alabi, O.A. In vivo evaluation of genetic and systemic toxicity of aqueous extracts of phyllanthus amarus in mice and rats. international journal of toxicological and pharmacological research, 2015, vol. 7, no. 4 . .
Endpoint study #7: Trinh, Binh T. D., Staerk, Dan., Jager, Anna K. Screening for potential alpha-glucosidase and alpha-amylase inhibitory constituents from selected Vietnamese plants used to treat type 2 diabetes . journal of ethnopharmacology, 2016, vol. 186, p. 189–195. DOI: 10.1016/j.jep.2016.03.060. [DOI link]
Genotox #1: Bakare, A.A., Oguntolu, G.O., Adedokun, L.A., Amao, A.A., Oyeyemi, I.T., Alimba, C.G., Alabi, O.A. In vivo evaluation of genetic and systemic toxicity of aqueous extracts of phyllanthus amarus in mice and rats. international journal of toxicological and pharmacological research, 2015, vol. 7, no. 4 . .