Draft - work in progress
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- Lima bean (as plant) // Phaseolus lunatus L.
Lima bean (as plant) // Phaseolus lunatus L.
- Family:
- Fabaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 2494
- Number of processed references:
- 7
Composition #1: Mazur, Witold M., Duke, James A., Wahala, Kristiina., Rasku, Sirpa., Adlercreutz, Herman. Isoflavonoids and lignans in legumes: nutritional and health aspects in humans. journal of nutritional biochemistry, 1998, vol. 9, no. 4, p. 193–200. .
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-
Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
diethyl ether
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Substance:
daidzein (RF-00000061-NTR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Microgram/100 gram (G046A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
12.2 - 89
-
Internal remarks:
Daidzein in seeds
Composition #2: Mazur, Witold M., Duke, James A., Wahala, Kristiina., Rasku, Sirpa., Adlercreutz, Herman. Isoflavonoids and lignans in legumes: nutritional and health aspects in humans. journal of nutritional biochemistry, 1998, vol. 9, no. 4, p. 193–200. .
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
diethyl ether
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Substance:
secoisolarisiresinol (RF-00000390-NTR)
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Additional substance description:
anhydrosecoisolariciresinol and secoisolariciresinol
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Analytical method code:
GC-MS (F046A)
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Result unit:
Microgram/100 gram (G046A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
158-185
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Internal remarks:
anhydrosecoisolariciresinol and secoisolariciresinol in seeds
Composition #3: Mazur, Witold M., Duke, James A., Wahala, Kristiina., Rasku, Sirpa., Adlercreutz, Herman. Isoflavonoids and lignans in legumes: nutritional and health aspects in humans. journal of nutritional biochemistry, 1998, vol. 9, no. 4, p. 193–200. .
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
diethyl ether
-
Substance:
biochanin-A (RF-00004182-PAR)
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Analytical method code:
GC-MS (F046A)
-
Result unit:
Microgram/100 gram (G046A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0 - 2.7
-
Internal remarks:
Biochanin A in seeds
Composition #4: Mazur, Witold M., Duke, James A., Wahala, Kristiina., Rasku, Sirpa., Adlercreutz, Herman. Isoflavonoids and lignans in legumes: nutritional and health aspects in humans. journal of nutritional biochemistry, 1998, vol. 9, no. 4, p. 193–200. .
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
diethyl ether
-
Substance:
coumestrol (RF-00000055-NTR)
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Analytical method code:
GC-MS (F046A)
-
Result unit:
Microgram/100 gram (G046A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0 - 10
-
Internal remarks:
Coumestrol in seeds
Composition #5: Mazur, Witold M., Duke, James A., Wahala, Kristiina., Rasku, Sirpa., Adlercreutz, Herman. Isoflavonoids and lignans in legumes: nutritional and health aspects in humans. journal of nutritional biochemistry, 1998, vol. 9, no. 4, p. 193–200. .
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
diethyl ether
-
Substance:
formononetin (RF-00000291-NTR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Microgram/100 gram (G046A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
9 - 12.4
-
Internal remarks:
Formononetin in seeds
Composition #6: Mazur, Witold M., Duke, James A., Wahala, Kristiina., Rasku, Sirpa., Adlercreutz, Herman. Isoflavonoids and lignans in legumes: nutritional and health aspects in humans. journal of nutritional biochemistry, 1998, vol. 9, no. 4, p. 193–200. .
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
diethyl ether
-
Substance:
matairesinol (RF-00000331-NTR)
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Analytical method code:
GC-MS (F046A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Traces of matairesinol in seeds
Composition #7: Mazur, Witold M., Duke, James A., Wahala, Kristiina., Rasku, Sirpa., Adlercreutz, Herman. Isoflavonoids and lignans in legumes: nutritional and health aspects in humans. journal of nutritional biochemistry, 1998, vol. 9, no. 4, p. 193–200. .
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
diethyl ether
-
Substance:
genistein (RF-00000297-NTR)
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Analytical method code:
GC-MS (F046A)
-
Result unit:
Microgram/100 gram (G046A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
10.6 - 19.2
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Internal remarks:
Genistein in seeds
Composition #8: Laurena, Antonio C., Revilleza, Ma. Jamela R., Mendona, Evelyn Mae T. Polyphenols, Phytate, Cyanogenic Glycosides, and Trypsin Inhibitor Activity of Several Philippine Indigenous Food Legumes . journal of food composition and analysis, 1994, vol. 7, no. 3, p. 194–202. DOI: 10.1006/jfca.1994.1019.
[
DOI link]
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Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
trichloroacetic acid
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Substance:
phytic acid (RF-00000363-NTR)
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Substance used for equivalence:
Phosphorus (P) (RF-00000031-CHE)
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Analytical method - additional description:
McCance and Widdowson method modified by Wheeler and Ferrel
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Result unit:
Microgram/gram (G049A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
8 - 11.6
-
Internal remarks:
Phytic acid in seeds
Composition #9: Laurena, Antonio C., Revilleza, Ma. Jamela R., Mendona, Evelyn Mae T. Polyphenols, Phytate, Cyanogenic Glycosides, and Trypsin Inhibitor Activity of Several Philippine Indigenous Food Legumes . journal of food composition and analysis, 1994, vol. 7, no. 3, p. 194–202. DOI: 10.1006/jfca.1994.1019.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
HCL
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Substance:
Cyanogenic glycosides (RF-00004375-PAR)
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Substance used for equivalence:
Hydrocyanic acid (RF-00000333-TOX)
-
Analytical method code:
Unspecified (F598A)
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Analytical method - additional description:
Reay and Conn (1970) method
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Result unit:
Microgram/gram (G049A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.8 - 8.9
-
Internal remarks:
cyanogenic glycosides in mature leaves
Composition #10: Laurena, Antonio C., Revilleza, Ma. Jamela R., Mendona, Evelyn Mae T. Polyphenols, Phytate, Cyanogenic Glycosides, and Trypsin Inhibitor Activity of Several Philippine Indigenous Food Legumes . journal of food composition and analysis, 1994, vol. 7, no. 3, p. 194–202. DOI: 10.1006/jfca.1994.1019.
[
DOI link]
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
HCL
-
Substance:
Cyanogenic glycosides (RF-00004375-PAR)
-
Substance used for equivalence:
Hydrocyanic acid (RF-00000333-TOX)
-
Analytical method code:
Unspecified (F598A)
-
Analytical method - additional description:
Reay and Conn (1970) method
-
Result unit:
Microgram/gram (G049A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.6-1
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Internal remarks:
cyanogenic glycosides in immature seeds
Composition #11: Laurena, Antonio C., Revilleza, Ma. Jamela R., Mendona, Evelyn Mae T. Polyphenols, Phytate, Cyanogenic Glycosides, and Trypsin Inhibitor Activity of Several Philippine Indigenous Food Legumes . journal of food composition and analysis, 1994, vol. 7, no. 3, p. 194–202. DOI: 10.1006/jfca.1994.1019.
[
DOI link]
-
-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
HCL
-
Substance:
Cyanogenic glycosides (RF-00004375-PAR)
-
Substance used for equivalence:
Hydrocyanic acid (RF-00000333-TOX)
-
Analytical method code:
Unspecified (F598A)
-
Analytical method - additional description:
Reay and Conn (1970) method
-
Result unit:
Microgram/gram (G049A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
3.3 - 10.4
-
Internal remarks:
cyanogenic glycosides in immature leaves
Composition #12: Cressey, P., Saunders, D., Goodman, J. Cyanogenic glycosides in plant-based foods available in New Zealand. food additives and contaminants - part a chemistry, analysis, control, exposure and risk assessment, 2013, vol. 30, no. 11, p. 1946–1953. DOI: 10.1080/19440049.2013.825819.
[
DOI link]
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Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
H3PO4 + NaCl
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Substance:
Hydrocyanic acid (RF-00000333-TOX)
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Result unit:
Milligram/kilogram (G061A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
32
-
Internal remarks:
Hydrocyanic acid in seeds (beans)
Composition #13: Shlichta, J. Gwen., Glauser, Gaetan., Benrey, Betty. Variation in Cyanogenic Glycosides Across Populations of Wild Lima Beans (Phaseolus lunatus) Has No Apparent Effect on Bruchid Beetle Performance . journal of chemical ecology, 2014, vol. 40, no. 5, p. 468–475. DOI: 10.1007/s10886-014-0434-0.
[
DOI link]
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
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Substance:
lotaustralin (RF-00003908-PAR)
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Analytical method code:
Chromatographic tests (F015A)
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Analytical method - additional description:
UPLC-MS
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Result unit:
Microgram/gram (G049A)
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Result expression:
Dry matter (B002A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
220 - 790
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Internal remarks:
lotaustralin in seeds
Composition #14: Shlichta, J. Gwen., Glauser, Gaetan., Benrey, Betty. Variation in Cyanogenic Glycosides Across Populations of Wild Lima Beans (Phaseolus lunatus) Has No Apparent Effect on Bruchid Beetle Performance . journal of chemical ecology, 2014, vol. 40, no. 5, p. 468–475. DOI: 10.1007/s10886-014-0434-0.
[
DOI link]
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
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Substance:
linamarin (RF-00003902-PAR)
-
Analytical method code:
Chromatographic tests (F015A)
-
Analytical method - additional description:
UPLC-MS
-
Result unit:
Milligram/gram (G060A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
14 - 26
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Internal remarks:
linamarin in seeds
Endpoint study
#1: Guignard, L. The hydrogen cyanide supplying bean (Phaseolus Lunatus). Historical, botanical and chemical study. New procedure for the proof of hydrocyanic acid. machine translation . bull. des sciences pharmacol., 1906, vol. 13, p. 129–38. .
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Study relevance:
Human health
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Plant part:
Seed (as part-nature) (A066P)
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Human (as organism) (A056J)
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-
Number of organisms dosed:
1
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
NOT REPORTED (TOX17A)
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Effect description:
Death roughly 10 hours after ingestion of beans, other people who ate lower amount have not died
-
Effect or parameter linked to the endpoint:
mortality (CHD010BE)
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Internal remarks:
Death roughly 10 hours after ingestion of beans
Endpoint study
#2: Jaffé, W.G. Toxische und Wachstumshemmende Faktoren in Bohnen. qualitas plantarum et materiae vegetabiles, 1969, vol. 17, no. 2, p. 113–130. DOI: 10.1007/BF01100627.
[
DOI link]
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Study relevance:
Human health
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Plant part:
Seed (as part-nature) (A066P)
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Type of toxicological test:
subchronic (CHD013TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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-
Unit of exposure duration:
Week (G205A)
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Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
Digestive (TOX18A)
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Target tissue:
digestive: Stomach (TT027A)
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Effect description:
growth inhibiting action in rats, but their ingestion is not lethal. Trypsin inhibition is not toxic, but digestibility is low
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Effect or parameter linked to the endpoint:
enzyme inhibition (CHD032BE)
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Internal remarks:
Growth inhibiting action in rats, but their ingestion is not lethal. Trypsin inhibition is not toxic, but digestibility is low
Endpoint study
#3: Betancur-Ancona, D., Segura-Campos, M., Rosado-Rubio, G., Franco, L.S., Chel-Guerrero, L. Chemical composition and anti-nutritional factors in five tropical legume seeds. beans: nutrition, consumption and health, 2012, p. 117–141. .
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Study relevance:
Human health
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Plant part:
Seed (as part-nature) (A066P)
-
Type of toxicological test:
case report (CHD060TT)
-
Tested organism:
Human (as organism) (A056J)
-
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
acute gastroenteritis with nausea, vomiting, diarrhea and abdominal pain in infants and adults
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Effect or parameter linked to the endpoint:
other (CHD003BE)
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Internal remarks:
Intake of raw seeds causes acute gastroenteritis with nausea, vomiting, diarrhea and abdominal pain in infants and adults.