Draft - work in progress
-
- Phalaris aquatica L.
Phalaris aquatica L.
- Family:
- Poaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 967
- Number of processed references:
- 11
Composition #1: Anderton, Neil., Cockrum, Peter A., Colegate, Steven M., Edgar, John A., Flower, Kirsty. New alkaloids from Phalaris spp.: a cause for concern?. acs symposium series, 2000, vol. 745(Natural and Selected Synthetic Toxins), p. 140–153. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Additional extraction description:
unspecified
-
Substance:
N,N-DIMETHYLTRYPTAMINE (RF-00004089-PAR)
-
Analytical method code:
Chromatographic tests (F015A)
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.012 - 0.04
-
Internal remarks:
DIMETHYLTRYPTAMINE in herb
Composition #2: Anderton, Neil., Cockrum, Peter A., Colegate, Steven M., Edgar, John A., Flower, Kirsty. New alkaloids from Phalaris spp.: a cause for concern?. acs symposium series, 2000, vol. 745(Natural and Selected Synthetic Toxins), p. 140–153. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Additional extraction description:
unspecified
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Additional substance description:
tetrahydro-ß-carbolines
-
Analytical method code:
Chromatographic tests (F015A)
-
Analytical method - additional description:
Chromatography and HPLC
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.004
-
Internal remarks:
tetrahydro-ß-carbolines in herb
Composition #3: Anderton, Neil., Cockrum, Peter A., Colegate, Steven M., Edgar, John A., Flower, Kirsty. New alkaloids from Phalaris spp.: a cause for concern?. acs symposium series, 2000, vol. 745(Natural and Selected Synthetic Toxins), p. 140–153. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Additional extraction description:
unspecified
-
Substance:
gramine (RF-00003411-PAR)
-
Analytical method code:
Chromatographic tests (F015A)
-
Analytical method - additional description:
Chromatography and HPLC
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.001 - 0.3
-
Internal remarks:
gramine in herb
Composition #4: Anderton, Neil., Cockrum, Peter A., Colegate, Steven M., Edgar, John A., Flower, Kirsty. New alkaloids from Phalaris spp.: a cause for concern?. acs symposium series, 2000, vol. 745(Natural and Selected Synthetic Toxins), p. 140–153. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Additional extraction description:
unspecified
-
Substance:
N-Methyltyramine (RF-00013322-PAR)
-
Analytical method code:
Chromatographic tests (F015A)
-
Analytical method - additional description:
Chromatography and HPLC
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.012
-
Internal remarks:
N-methyltyramine in herb
Composition #5: Anderton, Neil., Cockrum, Peter A., Colegate, Steven M., Edgar, John A., Flower, Kirsty. New alkaloids from Phalaris spp.: a cause for concern?. acs symposium series, 2000, vol. 745(Natural and Selected Synthetic Toxins), p. 140–153. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Additional extraction description:
unspecified
-
Substance:
hordenine (RF-00003427-PAR)
-
Analytical method code:
Chromatographic tests (F015A)
-
Analytical method - additional description:
Chromatography and HPLC
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.009
-
Internal remarks:
hordenine in herb
Composition #6: Passos, I.D., Mironidou-Tzouveleki, M. Hallucinogenic Plants in the Mediterranean Countries. neuropathology of drug addictions and substance misuse, 2016, vol. 2, p. 761–772. DOI: 10.1016/B978-0-12-800212-4.00071-6.
[
DOI link]
-
-
Plant part:
Unspecified (A07XD)
-
Additional extraction description:
unspecified
-
Substance:
carboline alkaloids (RF-00004384-PAR)
-
Analytical method code:
Unspecified (F598A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Carboline alkaloids in unspecified parts
Composition #7: Passos, I.D., Mironidou-Tzouveleki, M. Hallucinogenic Plants in the Mediterranean Countries. neuropathology of drug addictions and substance misuse, 2016, vol. 2, p. 761–772. DOI: 10.1016/B978-0-12-800212-4.00071-6.
[
DOI link]
-
-
Plant part:
Unspecified (A07XD)
-
Additional extraction description:
unspecified
-
Substance:
tryptamine alkaloids (RF-00004388-PAR)
-
Analytical method code:
Unspecified (F598A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
tryptamine alkaloids in unspecified parts
Composition #8: Passos, I.D., Mironidou-Tzouveleki, M. Hallucinogenic Plants in the Mediterranean Countries. neuropathology of drug addictions and substance misuse, 2016, vol. 2, p. 761–772. DOI: 10.1016/B978-0-12-800212-4.00071-6.
[
DOI link]
-
-
Plant part:
Unspecified (A07XD)
-
Additional extraction description:
unspecified
-
Substance:
gramine (RF-00003411-PAR)
-
Additional substance description:
gramine alkaloids
-
Analytical method code:
Unspecified (F598A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
gramine alkaloids in unspecified parts
Composition #9: Passos, I.D., Mironidou-Tzouveleki, M. Hallucinogenic Plants in the Mediterranean Countries. neuropathology of drug addictions and substance misuse, 2016, vol. 2, p. 761–772. DOI: 10.1016/B978-0-12-800212-4.00071-6.
[
DOI link]
-
-
Plant part:
Unspecified (A07XD)
-
Additional extraction description:
unspecified
-
Substance:
N,N-Dimethyl-5-methoxytryptamine (RF-00003828-PAR)
-
Analytical method code:
Unspecified (F598A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
5-methoxy-N,N-dimethyltryptamine in unspecified parts
Composition #10: Passos, I.D., Mironidou-Tzouveleki, M. Hallucinogenic Plants in the Mediterranean Countries. neuropathology of drug addictions and substance misuse, 2016, vol. 2, p. 761–772. DOI: 10.1016/B978-0-12-800212-4.00071-6.
[
DOI link]
-
-
Plant part:
Unspecified (A07XD)
-
Additional extraction description:
unspecified
-
Substance:
Tyramine (RF-00000007-BGA)
-
Additional substance description:
methyltyramine
-
Analytical method code:
Unspecified (F598A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
methyltyramine in unspecified parts
Composition #11: Passos, I.D., Mironidou-Tzouveleki, M. Hallucinogenic Plants in the Mediterranean Countries. neuropathology of drug addictions and substance misuse, 2016, vol. 2, p. 761–772. DOI: 10.1016/B978-0-12-800212-4.00071-6.
[
DOI link]
-
-
Plant part:
Unspecified (A07XD)
-
Additional extraction description:
unspecified
-
Substance:
Tyramine (RF-00000007-BGA)
-
Additional substance description:
Tyramine alkaloids
-
Analytical method code:
Unspecified (F598A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Tyramine alkaloids in unspecified parts
Composition #12: Passos, I.D., Mironidou-Tzouveleki, M. Hallucinogenic Plants in the Mediterranean Countries. neuropathology of drug addictions and substance misuse, 2016, vol. 2, p. 761–772. DOI: 10.1016/B978-0-12-800212-4.00071-6.
[
DOI link]
-
-
Plant part:
Unspecified (A07XD)
-
Additional extraction description:
unspecified
-
Substance:
bufotenine (RF-00003718-PAR)
-
Analytical method code:
Unspecified (F598A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
bufotenine in unspecified parts
Composition #13: Passos, I.D., Mironidou-Tzouveleki, M. Hallucinogenic Plants in the Mediterranean Countries. neuropathology of drug addictions and substance misuse, 2016, vol. 2, p. 761–772. DOI: 10.1016/B978-0-12-800212-4.00071-6.
[
DOI link]
-
-
Plant part:
Unspecified (A07XD)
-
Additional extraction description:
unspecified
-
Substance:
hordenine (RF-00003427-PAR)
-
Analytical method code:
Unspecified (F598A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
hordenine in unspecified parts
Composition #14: Passos, I.D., Mironidou-Tzouveleki, M. Hallucinogenic Plants in the Mediterranean Countries. neuropathology of drug addictions and substance misuse, 2016, vol. 2, p. 761–772. DOI: 10.1016/B978-0-12-800212-4.00071-6.
[
DOI link]
-
-
Plant part:
Unspecified (A07XD)
-
Additional extraction description:
unspecified
-
Substance:
Tryptamine (RF-00000009-BGA)
-
Additional substance description:
5-methoxytryptamine
-
Analytical method code:
Unspecified (F598A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
5-methoxytryptamine in unspecified parts
Composition #15: Bourke, CA., Colegate, SM., Rendell, D., Bunker, EC., Kuhn, RP. Peracute ammonia toxicity: A consideration in the pathogenesis of Phalaris aquatica 'Polioencephalomalacia-like sudden death' poisoning of sheep and cattle . australian veterinary journal, 2005, vol. 83, no. 3, p. 168–171. DOI: 10.1111/j.1751-0813.2005.tb11631.x.
[
DOI link]
-
-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Additional extraction description:
unspecified
-
Substance:
indole alkaloids (RF-00004503-PAR)
-
Analytical method code:
Unspecified (F598A)
-
Result unit:
Gram/kilogram (G015A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
< 2.8
-
Internal remarks:
Indole alkaloids in leaves
Composition #16: Culvenor, RA., Reed, KFM., McDonald, SE. Comparative levels of dimethyltryptamine- and tyramine-related alkaloid toxins in Australian cultivars and some wild populations of Phalaris aquatica . australian journal of agricultural research, 2005, vol. 56, no. 12, p. 1395–1403. DOI: 10.1071/AR05040.
[
DOI link]
-
-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
HCl
-
Substance:
Tyramine (RF-00000007-BGA)
-
Additional substance description:
Tyramine Alkaloids
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Result unit:
Milligram/100 gram (G057A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.58 - 42.69
-
Internal remarks:
Tyramine Alkaloids in leaf
Composition #17: Culvenor, RA., Reed, KFM., McDonald, SE. Comparative levels of dimethyltryptamine- and tyramine-related alkaloid toxins in Australian cultivars and some wild populations of Phalaris aquatica . australian journal of agricultural research, 2005, vol. 56, no. 12, p. 1395–1403. DOI: 10.1071/AR05040.
[
DOI link]
-
-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
HCl
-
Substance:
bufotenine (RF-00003718-PAR)
-
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Bufotenine in leaf
Composition #18: Culvenor, RA., Reed, KFM., McDonald, SE. Comparative levels of dimethyltryptamine- and tyramine-related alkaloid toxins in Australian cultivars and some wild populations of Phalaris aquatica . australian journal of agricultural research, 2005, vol. 56, no. 12, p. 1395–1403. DOI: 10.1071/AR05040.
[
DOI link]
-
-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
HCl
-
Substance:
N,N-DIMETHYLTRYPTAMINE (RF-00004089-PAR)
-
Additional substance description:
DimethylTryptamine Alkaloids
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Result unit:
Milligram/100 gram (G057A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.030 - 20.52
-
Internal remarks:
DimethylTryptamine Alkaloids in leaf
Composition #19: Zhou, Lili., Hopkins, Andrew A., Huhman, David V., Sumner, Lloyd W. Efficient and sensitive method for quantitative analysis of alkaloids in hardinggrass (Phalaris aquatica L.) . journal of agricultural and food chemistry, 2006, vol. 54, no. 25, p. 9287–9291. DOI: 10.1021/jf061819k.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
gramine (RF-00003411-PAR)
-
Analytical method code:
UHPLC-MS-MS (F608A)
-
Result unit:
Milligram/kilogram (G061A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
22.5 - 47.5
-
Internal remarks:
gramine in aerial parts
Composition #20: Zhou, Lili., Hopkins, Andrew A., Huhman, David V., Sumner, Lloyd W. Efficient and sensitive method for quantitative analysis of alkaloids in hardinggrass (Phalaris aquatica L.) . journal of agricultural and food chemistry, 2006, vol. 54, no. 25, p. 9287–9291. DOI: 10.1021/jf061819k.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
N,N-DIMETHYLTRYPTAMINE (RF-00004089-PAR)
-
Additional substance description:
dimethyltryptamine
-
Analytical method code:
UHPLC-MS-MS (F608A)
-
Result unit:
Milligram/kilogram (G061A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
66.3 - 177
-
Internal remarks:
dimethyltryptamine in aerial parts
Composition #21: Zhou, Lili., Hopkins, Andrew A., Huhman, David V., Sumner, Lloyd W. Efficient and sensitive method for quantitative analysis of alkaloids in hardinggrass (Phalaris aquatica L.) . journal of agricultural and food chemistry, 2006, vol. 54, no. 25, p. 9287–9291. DOI: 10.1021/jf061819k.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
N,N-DIMETHYLTRYPTAMINE (RF-00004089-PAR)
-
Additional substance description:
5-methoxydimethyltryptamine
-
Analytical method code:
UHPLC-MS-MS (F608A)
-
Result unit:
Milligram/kilogram (G061A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
176
-
Internal remarks:
5-methoxydimethyltryptamine in aerial parts
Composition #22: Zhou, Lili., Hopkins, Andrew A., Huhman, David V., Sumner, Lloyd W. Efficient and sensitive method for quantitative analysis of alkaloids in hardinggrass (Phalaris aquatica L.) . journal of agricultural and food chemistry, 2006, vol. 54, no. 25, p. 9287–9291. DOI: 10.1021/jf061819k.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
N-Methyltyramine (RF-00013322-PAR)
-
Additional substance description:
methyltyramine
-
Analytical method code:
UHPLC-MS-MS (F608A)
-
Result unit:
Milligram/kilogram (G061A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
171.3 - 262.5
-
Internal remarks:
methyltyramine in aerial parts
Composition #23: Zhou, Lili., Hopkins, Andrew A., Huhman, David V., Sumner, Lloyd W. Efficient and sensitive method for quantitative analysis of alkaloids in hardinggrass (Phalaris aquatica L.) . journal of agricultural and food chemistry, 2006, vol. 54, no. 25, p. 9287–9291. DOI: 10.1021/jf061819k.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
hordenine (RF-00003427-PAR)
-
Analytical method code:
UHPLC-MS-MS (F608A)
-
Result unit:
Milligram/kilogram (G061A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
57.5 - 833.8
-
Internal remarks:
hordenine in aerial parts
Composition #24: ORAM, RN., WILLIAMS, JD. VARIATION IN CONCENTRATION AND COMPOSITION OF TOXIC ALKALOIDS AMONG STRAINS OF PHALARIS TUBEROSA L . nature, 1967, vol. 213, no. 5079, p. 946–&. DOI: 10.1038/213946a0.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Hydrocloric acid
-
Substance:
N,N-DIMETHYLTRYPTAMINE (RF-00004089-PAR)
-
Additional substance description:
DimethylTryptamine Alkaloids
-
Analytical method code:
Chromatographic tests (F015A)
-
Result unit:
Milligram/100 gram (G057A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
1- 87
-
Internal remarks:
DimethylTryptamine Alkaloids in aerial parts
Composition #25: ORAM, RN., WILLIAMS, JD. VARIATION IN CONCENTRATION AND COMPOSITION OF TOXIC ALKALOIDS AMONG STRAINS OF PHALARIS TUBEROSA L . nature, 1967, vol. 213, no. 5079, p. 946–&. DOI: 10.1038/213946a0.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Hydrocloric acid
-
Substance:
indole alkaloids (RF-00004503-PAR)
-
Analytical method code:
Chromatographic tests (F015A)
-
Result unit:
Milligram/100 gram (G057A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
3 - 178
-
Internal remarks:
total alkaloids in aerial parts
Composition #26: FRAHN, JL., OKEEFE, DF. OCCURRENCE OF TETRAHYDRO-BETA-CARBOLINE ALKALOIDS IN PHALARIS-TUBEROSA (GRAMINEAE) . australian journal of chemistry, 1971, vol. 24, no. 10, p. 2189–&. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
chloroform
-
Substance:
indole alkaloids (RF-00004503-PAR)
-
Additional substance description:
2-methyl-1,2,3,4-tetrahydro-P-carboline, 6-methoxy- 2-methyl-1,2,3,4-tetrahydro-P-carboline
-
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.001 - 0.06
-
Internal remarks:
indole alkaloids in aerial parts
Composition #27: KENNEDY, DJ., CREGAN, PD., GLASTONBURY, JRW., GOLLAND, DT., DAY, DG. POISONING OF CATTLE GRAZING A LOW-ALKALOID CULTIVAR OF PHALARIS-AQUATICA, SIROLAN . australian veterinary journal, 1986, vol. 63, no. 3, p. 88–89. DOI: 10.1111/j.1751-0813.1986.tb02938.x.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Additional extraction description:
unspecified
-
Substance:
indole alkaloids (RF-00004503-PAR)
-
Analytical method code:
Unspecified (F598A)
-
Result unit:
Milligram/100 gram (G057A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.25 - 13.26
-
Internal remarks:
alkaloids in aerial parts
Endpoint study
#1: Anderton, Neil., Cockrum, Peter A., Colegate, Steven M., Edgar, John A., Flower, Kirsty. New alkaloids from Phalaris spp.: a cause for concern?. acs symposium series, 2000, vol. 745(Natural and Selected Synthetic Toxins), p. 140–153. .
-
Study relevance:
Animal (target species) health
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Type of toxicological test:
case report (CHD060TT)
-
-
Tested organism:
Ruminants (generic) (as animal) (A169S)
-
-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
Neurologic (TT004A)
-
Effect description:
muscular incoordination or "staggers" syndrome in sheep and cattle. (Signs observed within days and may persist for several weeks. Long-lasting neurological signs may be observed several months)
-
Effect or parameter linked to the endpoint:
neurology (CHD027BE)
-
Internal remarks:
muscular incoordination in sheeps and cattles
Endpoint study
#2: Anderton, Neil., Cockrum, Peter A., Colegate, Steven M., Edgar, John A., Flower, Kirsty. New alkaloids from Phalaris spp.: a cause for concern?. acs symposium series, 2000, vol. 745(Natural and Selected Synthetic Toxins), p. 140–153. .
-
Study relevance:
Animal (target species) health
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Type of toxicological test:
case report (CHD060TT)
-
-
Tested organism:
Ruminants (generic) (as animal) (A169S)
-
-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
PULMONARY AND CARDIAC (TOX08A)
-
Target tissue:
cardiovascular / haematological: Heart (TT011A)
-
Effect description:
Acute, sudden onset heart failure leading to death (an arrhythmic tachychardia leading to ventricular fibrillation and cardiac arrest, with no preceding neurological signs)
-
Effect or parameter linked to the endpoint:
mortality (CHD010BE)
-
Internal remarks:
Heart failure in ruminants
Endpoint study
#3: Anderton, Neil., Cockrum, Peter A., Colegate, Steven M., Edgar, John A., Flower, Kirsty. New alkaloids from Phalaris spp.: a cause for concern?. acs symposium series, 2000, vol. 745(Natural and Selected Synthetic Toxins), p. 140–153. .
-
Study relevance:
Animal (target species) health
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Type of toxicological test:
case report (CHD060TT)
-
-
Tested organism:
Ruminants (generic) (as animal) (A169S)
-
-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
neurologic: Brain (TT034A)
-
Effect description:
(polioencephalomalacia) a degenerative lesion of the brain leading to death
-
Effect or parameter linked to the endpoint:
mortality (CHD010BE)
-
Internal remarks:
Brain lesion in ruminants
Endpoint study
#4: Anderton, Neil., Cockrum, Peter A., Colegate, Steven M., Edgar, John A., Flower, Kirsty. New alkaloids from Phalaris spp.: a cause for concern?. acs symposium series, 2000, vol. 745(Natural and Selected Synthetic Toxins), p. 140–153. .
-
Study relevance:
Animal (target species) health
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Type of toxicological test:
case report (CHD060TT)
-
-
Tested organism:
Ruminants (generic) (as animal) (A169S)
-
-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
Neurologic (TT004A)
-
Effect description:
Apparent blindness, depression, head and body tremors, aimless wandering, opisthotonus and either cerebral convulsions or coma.
-
Effect or parameter linked to the endpoint:
other (CHD003BE)
-
Internal remarks:
Long term signs fellowing brain lesion among surviving ruminants
Endpoint study
#5: Bacci, B., Whiteley, P.L., Barrow, M., Phillips, P.H., Dalziel, J., El-Hage, C.M. Chronic phalaris toxicity in eastern grey kangaroos (Macropus giganteus). australian veterinary journal, 2014, vol. 92, no. 12, p. 504–508. DOI: 10.1111/avj.12272.
[
DOI link]
-
Study relevance:
Animal (target species) health
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Type of toxicological test:
case report (CHD060TT)
-
Tested organism:
Mammals (as animal) (A056H)
-
-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
-
Unit of exposure duration:
Hour (G099A)
-
Number of organisms dosed:
7
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Effect description:
neurological signs characterised by ataxia, wide-based stance, hypermetric gait and generalised muscle tremors in kangaroos
-
Effect or parameter linked to the endpoint:
neurology (CHD027BE)
-
Internal remarks:
neurotoxicity in kangaroos
Endpoint study
#6: Bacci, B., Whiteley, P.L., Barrow, M., Phillips, P.H., Dalziel, J., El-Hage, C.M. Chronic phalaris toxicity in eastern grey kangaroos (Macropus giganteus). australian veterinary journal, 2014, vol. 92, no. 12, p. 504–508. DOI: 10.1111/avj.12272.
[
DOI link]
-
Study relevance:
Animal (target species) health
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Type of toxicological test:
case report (CHD060TT)
-
Tested organism:
Mammals (as animal) (A056H)
-
-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
-
Unit of exposure duration:
Hour (G099A)
-
Number of organisms dosed:
7
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Effect description:
One of the seven studied kangaroo observed to have neurological deficits was found dead the following day on pastures containing P. aquatica.
-
Effect or parameter linked to the endpoint:
mortality (CHD010BE)
-
Internal remarks:
Mortality in kangaroos
Endpoint study
#7: LE SOUEF, H D. Poisoning of sheep by Phalaris tuberosa.. australian veterinary journal, 1948, vol. 24, no. 1, p. 12–12. .
-
Study relevance:
Animal (target species) health
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Type of toxicological test:
case report (CHD060TT)
-
Limit test:
Not applicable
-
Tested organism:
Sheep (as animal) (A057G)
-
-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
Number of organisms dosed:
20
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
Neurologic (TT004A)
-
Effect description:
Hyperexcitability with twitching of the ears and lips, turning back the head, incoordination of movement and a staggering gait when disturbed.
-
Effect or parameter linked to the endpoint:
neurology (CHD027BE)
-
Internal remarks:
Neurotoxicity among sheeps
Endpoint study
#8: Bourke, CA., Colegate, SM., Rendell, D., Bunker, EC., Kuhn, RP. Peracute ammonia toxicity: A consideration in the pathogenesis of Phalaris aquatica 'Polioencephalomalacia-like sudden death' poisoning of sheep and cattle . australian veterinary journal, 2005, vol. 83, no. 3, p. 168–171. DOI: 10.1111/j.1751-0813.2005.tb11631.x.
[
DOI link]
-
Study relevance:
Animal (target species) health
-
Type of toxicological test:
case report (CHD060TT)
-
Limit test:
Not applicable
-
Tested organism:
Sheep (as animal) (A057G)
-
-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
-
Unit of exposure duration:
Day (G134A)
-
Number of organisms dosed:
23
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
Neurologic (TT004A)
-
Effect description:
The nervous form of Phalaris aquatica-associated sudden death (23 sheep died during six separate sudden death events)
-
Effect or parameter linked to the endpoint:
mortality (CHD010BE)
-
Internal remarks:
Mortality in sheeps
Endpoint study
#9: Bourke, CA., Colegate, SM., Rendell, D., Bunker, EC., Kuhn, RP. Peracute ammonia toxicity: A consideration in the pathogenesis of Phalaris aquatica 'Polioencephalomalacia-like sudden death' poisoning of sheep and cattle . australian veterinary journal, 2005, vol. 83, no. 3, p. 168–171. DOI: 10.1111/j.1751-0813.2005.tb11631.x.
[
DOI link]
-
Study relevance:
Animal (target species) health
-
Type of toxicological test:
case report (CHD060TT)
-
Limit test:
Not applicable
-
Tested organism:
Cattle (as animal) (A057E)
-
-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
-
Unit of exposure duration:
Day (G134A)
-
Number of organisms dosed:
61
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
Neurologic (TT004A)
-
Effect description:
29 out of 61 cattle died (between 12 hours and 4 days post exposure)
-
Effect or parameter linked to the endpoint:
mortality (CHD010BE)
-
Internal remarks:
Mortality in cattles
Endpoint study
#10: Bourke, CA., Colegate, SM., Rendell, D., Bunker, EC., Kuhn, RP. Peracute ammonia toxicity: A consideration in the pathogenesis of Phalaris aquatica 'Polioencephalomalacia-like sudden death' poisoning of sheep and cattle . australian veterinary journal, 2005, vol. 83, no. 3, p. 168–171. DOI: 10.1111/j.1751-0813.2005.tb11631.x.
[
DOI link]
-
Study relevance:
Animal (target species) health
-
Type of toxicological test:
case report (CHD060TT)
-
Limit test:
Not applicable
-
Tested organism:
Cattle (as animal) (A057E)
-
-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
-
Unit of exposure duration:
Day (G134A)
-
Number of organisms dosed:
61
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
Neurologic (TT004A)
-
Effect description:
14 cattle showed signs of: incoordination, aimless wandering, lack of awareness of their surroundings, recumbency, muscle fasciculations, tremors, opisthotonos, excess salivation, and tetanic spasms with limb paddling
-
Effect or parameter linked to the endpoint:
neurology (CHD027BE)
-
Internal remarks:
Neurotoxicity in cattles
Endpoint study
#11: Culvenor, RA., Reed, KFM., McDonald, SE. Comparative levels of dimethyltryptamine- and tyramine-related alkaloid toxins in Australian cultivars and some wild populations of Phalaris aquatica . australian journal of agricultural research, 2005, vol. 56, no. 12, p. 1395–1403. DOI: 10.1071/AR05040.
[
DOI link]
-
Study relevance:
Animal (target species) health
-
Substance:
N,N-DIMETHYLTRYPTAMINE (RF-00004089-PAR)
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Type of toxicological test:
other (CHD008TT)
-
-
Tested organism:
Sheep (as animal) (A057G)
-
-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
Control groups used:
no data
-
Endpoint measured:
Lowest observed adverse effect level (CHD026EP)
-
Concentration unit:
Milligram/kilogram (G061A)
-
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
Neurologic (TT004A)
-
Effect description:
Lowest tryptamine alkaloids level to see a neurological toxicity in sheeps
-
Effect or parameter linked to the endpoint:
neurology (CHD027BE)
-
Internal remarks:
Neurological toxicity in sheeps
Endpoint study
#12: KENNEDY, DJ., CREGAN, PD., GLASTONBURY, JRW., GOLLAND, DT., DAY, DG. POISONING OF CATTLE GRAZING A LOW-ALKALOID CULTIVAR OF PHALARIS-AQUATICA, SIROLAN . australian veterinary journal, 1986, vol. 63, no. 3, p. 88–89. DOI: 10.1111/j.1751-0813.1986.tb02938.x.
[
DOI link]
-
Study relevance:
Animal (target species) health
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Type of toxicological test:
short-term toxicity (CHD017TT)
-
Limit test:
Not applicable
-
Tested organism:
Cattle (as animal) (A057E)
-
-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
-
Unit of exposure duration:
Day (G134A)
-
Number of organisms dosed:
2
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
Neurologic (TT004A)
-
Effect description:
Chronic phalaris intoxication terminated by acute congestive heart failure.
-
Effect or parameter linked to the endpoint:
mortality (CHD010BE)
-
Internal remarks:
Mortality caused by an acute congestive heart failure in cattle
Endpoint study
#13: KENNEDY, DJ., CREGAN, PD., GLASTONBURY, JRW., GOLLAND, DT., DAY, DG. POISONING OF CATTLE GRAZING A LOW-ALKALOID CULTIVAR OF PHALARIS-AQUATICA, SIROLAN . australian veterinary journal, 1986, vol. 63, no. 3, p. 88–89. DOI: 10.1111/j.1751-0813.1986.tb02938.x.
[
DOI link]
-
Study relevance:
Animal (target species) health
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Type of toxicological test:
chronic/long term toxicity (CHD004TT)
-
Limit test:
Not applicable
-
Tested organism:
Cattle (as animal) (A057E)
-
-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
-
Unit of exposure duration:
Month (G206A)
-
Number of organisms dosed:
4
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
Neurologic (TT004A)
-
Effect description:
Incoordination, muscle tremors, inability to swallow and excessive salivation
-
Effect or parameter linked to the endpoint:
neurology (CHD027BE)
-
Internal remarks:
Chronic neurotoxicity caused (chronic phalaris poisoning) in cattle
Endpoint study
#14: EDGAR, JA. TOXINS IN TEMPERATE GRASSES - IMPLICATIONS AND SOLUTIONS. new zealand journal of agricultural research, 1994, vol. 37, no. 3, p. 341–347. .
-
Study relevance:
Animal (target species) health
-
Type of toxicological test:
other (CHD008TT)
-
Limit test:
Not applicable
-
-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
PULMONARY AND CARDIAC (TOX08A)
-
Target tissue:
cardiovascular / haematological: Heart (TT011A)
-
Effect description:
pre-acute toxicity: sudden death as a result of heart failure with no nervous signs
-
Effect or parameter linked to the endpoint:
mortality (CHD010BE)
-
Internal remarks:
sudden death as a result of heart failure
Endpoint study
#15: EDGAR, JA. TOXINS IN TEMPERATE GRASSES - IMPLICATIONS AND SOLUTIONS. new zealand journal of agricultural research, 1994, vol. 37, no. 3, p. 341–347. .
-
Study relevance:
Animal (target species) health
-
Type of toxicological test:
other (CHD008TT)
-
-
Tested organism:
Sheep (as animal) (A057G)
-
-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
Neurologic (TT004A)
-
Effect description:
Acute toxicity :a neurological locomotor disorder characterised by incoordination of gait and head and body tremors but with quick recovery once removed from a toxic pasture
-
Effect or parameter linked to the endpoint:
neurology (CHD027BE)
-
Internal remarks:
acute neurologic disorder
Endpoint study
#16: EDGAR, JA. TOXINS IN TEMPERATE GRASSES - IMPLICATIONS AND SOLUTIONS. new zealand journal of agricultural research, 1994, vol. 37, no. 3, p. 341–347. .
-
Study relevance:
Animal (target species) health
-
Type of toxicological test:
chronic/long term toxicity (CHD004TT)
-
Limit test:
Not applicable
-
-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
Neurologic (TT004A)
-
Effect description:
Chronic toxicity :a neurological locomotor disorder characterised by incoordination of gait and head and body tremors persistent even after removal from the toxic pasture
-
Effect or parameter linked to the endpoint:
neurology (CHD027BE)
-
Internal remarks:
chronic neurologic disorder