EFSA Compendium of Botanicals

Draft - work in progress

Peucedanum ostruthium (L.) W.Koch.

Family:: Apiaceae
Approval state:: Approved
Number of articles retrieved:: 109
Number of processed references:: 8

Endpoint Studies

Genotoxicity

Composition #1: Varga, E., Simokovics, J., Szendrei, K., Reisch, J. Furanocoumarins and chromones from the fruits of Peucedanum ostrutbium L. (Koch) (Umbelliferae). fitoterapia, 1979, vol. 50, no. 6, p. 259–64. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

Furanocoumarins (RF-00004381-PAR)
Additional substance description:

neobyakangelicol
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

neobyakangelicol

Composition #2: Varga, E., Simokovics, J., Szendrei, K., Reisch, J. Furanocoumarins and chromones from the fruits of Peucedanum ostrutbium L. (Koch) (Umbelliferae). fitoterapia, 1979, vol. 50, no. 6, p. 259–64. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

hamaudol
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

hamaudol

Composition #3: Varga, E., Simokovics, J., Szendrei, K., Reisch, J. Furanocoumarins and chromones from the fruits of Peucedanum ostrutbium L. (Koch) (Umbelliferae). fitoterapia, 1979, vol. 50, no. 6, p. 259–64. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

pabulenol (RF-00003970-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

pabulenol

Composition #4: Varga, E., Simokovics, J., Szendrei, K., Reisch, J. Furanocoumarins and chromones from the fruits of Peucedanum ostrutbium L. (Koch) (Umbelliferae). fitoterapia, 1979, vol. 50, no. 6, p. 259–64. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

Peucenin (RF-00003985-PAR)
Additional substance description:

peucenin-7-Me ether
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

peucenin-7-Me ether

Composition #5: Luszczki, Jarogniew J., Andres-Mach, Marta., Glensk, Michal., Skalicka-Wozniak, Krystyna. Anticonvulsant effects of four linear furanocoumarins, bergapten, imperatorin, oxypeucedanin, and xanthotoxin, in the mouse maximal electroshock-induced seizure model: a comparative study. pharmacological reports, 2010, vol. 62, no. 6, p. 1231–1236. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether, chloroform
Substance:

oxypeucedanin (RF-00003968-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

oxypeucedanin in roots

Composition #6: Hethelyi, E. B., Galambosi, B., Szarka, S., Lemberkovics, E., Szoke, E. Phytochemical investigation of medicinal and culinary herbs. acta agronomica hungarica, 2012, vol. 60, no. 3, p. 201–207. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

distillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

GC/MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

1,8-cineole

Composition #7: Cisowski, W., Sawicka, U., Mardarowicz, M., Asztemborska, M., Luczkiewicz, M. Essential oil from herb and rhizome of Peucedanum ostruthium (L. Koch.) ex DC. . zeitschrift fur naturforschung c-a journal of biosciences, 2001, vol. 56, no. 11-12, p. 930–932. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

osthol (RF-00011008-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.5
Internal remarks:

osthol in essential oil from herb

Composition #8: Cisowski, W., Sawicka, U., Mardarowicz, M., Asztemborska, M., Luczkiewicz, M. Essential oil from herb and rhizome of Peucedanum ostruthium (L. Koch.) ex DC. . zeitschrift fur naturforschung c-a journal of biosciences, 2001, vol. 56, no. 11-12, p. 930–932. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.1
Internal remarks:

Myrcene in essential oil from herb

Composition #9: Cisowski, W., Sawicka, U., Mardarowicz, M., Asztemborska, M., Luczkiewicz, M. Essential oil from herb and rhizome of Peucedanum ostruthium (L. Koch.) ex DC. . zeitschrift fur naturforschung c-a journal of biosciences, 2001, vol. 56, no. 11-12, p. 930–932. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.3
Internal remarks:

Myrcene in essential oil from rhizomes

Composition #10: Cisowski, W., Sawicka, U., Mardarowicz, M., Asztemborska, M., Luczkiewicz, M. Essential oil from herb and rhizome of Peucedanum ostruthium (L. Koch.) ex DC. . zeitschrift fur naturforschung c-a journal of biosciences, 2001, vol. 56, no. 11-12, p. 930–932. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

osthol (RF-00011008-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.1
Internal remarks:

osthol in essential oil from rhizomes

Composition #11: Urbain, A., Marston, A., Hostettmann, K. Coumarins from Peucedanum ostruthium as inhibitors of acetylcholinesterase . pharmaceutical biology, 2005, vol. 43, no. 8, p. 647–650. DOI: 10.1080/13880200500382720. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane, CH2Cl2
Substance:

Peucenin (RF-00003985-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC - LC/MS, HPLC- LC/UV, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

peucenin in roots

Composition #12: Vogl, Sylvia., Zehl, Martin., Picker, Paolo., Urban, Ernst., Wawrosch, Christoph., Reznicek, Gottfried., Saukel, Johannes., Kopp, Brigitte. Identification and Quantification of Coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS . journal of agricultural and food chemistry, 2011, vol. 59, no. 9, p. 4371–4377. DOI: 10.1021/jf104772x. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichloromethane
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

ostruthin
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

HPLC-DAD-MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

16.47-31.31
Internal remarks:

ostruthin in roots

Composition #13: Vogl, Sylvia., Zehl, Martin., Picker, Paolo., Urban, Ernst., Wawrosch, Christoph., Reznicek, Gottfried., Saukel, Johannes., Kopp, Brigitte. Identification and Quantification of Coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS . journal of agricultural and food chemistry, 2011, vol. 59, no. 9, p. 4371–4377. DOI: 10.1021/jf104772x. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichloromethane
Substance:

isoimperatorin (RF-00003880-PAR)
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

HPLC-DAD-MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.96-6.99
Internal remarks:

isoimperatorin in roots

Composition #14: Vogl, Sylvia., Zehl, Martin., Picker, Paolo., Urban, Ernst., Wawrosch, Christoph., Reznicek, Gottfried., Saukel, Johannes., Kopp, Brigitte. Identification and Quantification of Coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS . journal of agricultural and food chemistry, 2011, vol. 59, no. 9, p. 4371–4377. DOI: 10.1021/jf104772x. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichloromethane
Substance:

osthol (RF-00011008-PAR)
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

HPLC-DAD-MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.25-8.81
Internal remarks:

osthole in roots

Composition #15: Vogl, Sylvia., Zehl, Martin., Picker, Paolo., Urban, Ernst., Wawrosch, Christoph., Reznicek, Gottfried., Saukel, Johannes., Kopp, Brigitte. Identification and Quantification of Coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS . journal of agricultural and food chemistry, 2011, vol. 59, no. 9, p. 4371–4377. DOI: 10.1021/jf104772x. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichloromethane
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

ostruthol
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

HPLC-DAD-MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.28-9.22
Internal remarks:

ostruthol in roots

Composition #16: Vogl, Sylvia., Zehl, Martin., Picker, Paolo., Urban, Ernst., Wawrosch, Christoph., Reznicek, Gottfried., Saukel, Johannes., Kopp, Brigitte. Identification and Quantification of Coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS . journal of agricultural and food chemistry, 2011, vol. 59, no. 9, p. 4371–4377. DOI: 10.1021/jf104772x. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichloromethane
Substance:

oxypeucedanin hydrate (RF-00003969-PAR)
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

HPLC-DAD-MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.58-3.93
Internal remarks:

oxypeucedanin hydrate in roots

Composition #17: Vogl, Sylvia., Zehl, Martin., Picker, Paolo., Urban, Ernst., Wawrosch, Christoph., Reznicek, Gottfried., Saukel, Johannes., Kopp, Brigitte. Identification and Quantification of Coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS . journal of agricultural and food chemistry, 2011, vol. 59, no. 9, p. 4371–4377. DOI: 10.1021/jf104772x. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichloromethane
Substance:

imperatorin (RF-00003874-PAR)
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

HPLC-DAD-MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.88-14.27
Internal remarks:

imperatorin in roots

Composition #18: Vogl, Sylvia., Zehl, Martin., Picker, Paolo., Urban, Ernst., Wawrosch, Christoph., Reznicek, Gottfried., Saukel, Johannes., Kopp, Brigitte. Identification and Quantification of Coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS . journal of agricultural and food chemistry, 2011, vol. 59, no. 9, p. 4371–4377. DOI: 10.1021/jf104772x. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichloromethane
Substance:

oxypeucedanin (RF-00003968-PAR)
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

HPLC-DAD-MS
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.91-17.21
Internal remarks:

oxypeucedanin in roots

Composition #19: REISCH, J., KHALED, SA., SZENDREI, K., NOVAK, I. NATURAL PRODUCT CHEMISTRY .51. 5-ALKOXY-FURANOCOUMARINS FROM PEUCEDANUM-OSTRUTHIUM . phytochemistry, 1975, vol. 14, no. 8, p. 1889–1890. DOI: 10.1016/0031-9422(75)85329-5. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Furanocoumarins (RF-00004381-PAR)
Additional substance description:

oxypeucedanin, oxypeucedanin hydrate, tert-0-methyl-oxypeucedanin, pabulenon, isooxypeuccdanin
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furanocoumarins in roots

Composition #20: Hiermann, A., Schantl, D., SchubertZsilavecz, M., Reiner, J. Coumarins from Peucedanum ostruthium. phytochemistry, 1996, vol. 43, no. 4, p. 881–883. DOI: 10.1016/0031-9422(96)00176-8. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 15% or MeOH
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

6-(3-carboxybut-2-enyl)-7-hydroxycoumarin, 3´-acetate of oxypeucedanin hydrate
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

6-(3-carboxybut-2-enyl)-7-hydroxycoumarin, 3´-acetate of oxypeucedanin hydrate in roots