EFSA Compendium of Botanicals

Draft - work in progress

Perilla (as plant) // Perilla frutescens (L.) Britton

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 3249
Number of processed references:: 3

Compositions

#1: myristicin in leaves #2: neolignans (magnosalin, andamanicin) in leaves

Endpoint Studies

#1: atypical interstitial pneumonia in cattle (seeds and herb)

Genotoxicity

Composition #1: Lee, Hyun Jae., Lee, Kang Ro., Hong, Jang-Hee., Lee, Choong Jae. Effects of Caffeic Acid, Myristicin and Rosemarinic Acid on the Gene Expression and Production of Airway MUC5AC Mucin . natural product sciences, 2016, vol. 22, no. 4, p. 275–281. DOI: 10.20307/nps.2016.22.4.275. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

70% ethanol
Substance:

myristicin (RF-00003941-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

myristicin in leaves

Composition #2: Ryu, JH., Son, HJ., Lee, SH., Sohn, DH. Two neolignans from Perilla frutescens and their inhibition of nitric oxide synthase and tumor necrosis factor-alpha expression in murine macrophage cell line RAW 264.7 . bioorganic & medicinal chemistry letters, 2002, vol. 12, no. 4, p. 649–651. DOI: 10.1016/S0960-894X(01)00812-5. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOh
Substance:

neolignans (RF-00004386-PAR)
Additional substance description:

magnosalin and andamanicin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

neolignans (magnosalin, andamanicin) in leaves

Endpoint study #1: KERR, LA., JOHNSON, BJ., BURROWS, GE. INTOXICATION OF CATTLE BY PERILLA FRUTESCENS (PURPLE MINT). veterinary and human toxicology, 1986, vol. 28, no. 5, p. 412–416. .

Study relevance:

Animal (target species) health
Substance:

Perilla ketone (RF-00003549-PAR)
Plant part:

Seed (as part-nature) (A066P)
Preparation/Extraction method:

Fresh (A166Y)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Cattle (as animal) (A057E)
Sex:

No data
Route of exposure:

ORAL: FEED (OECD2230PL)
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Kilogram (G167A)
Effect concentration:

2.3
Critical effect:

PULMONARY AND CARDIAC (TOX08A)
Target tissue:

respiratory: Lung (TT041A)
Effect description:

atypical interstitial pneumonia
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

atypical interstitial pneumonia in cattle (seeds and herb)