Draft - work in progress
-
- Pausinystalia johimbe (K.Schum.) Pierre ex Beille // Corynanthe johimbe K.Schum.
Pausinystalia johimbe (K.Schum.) Pierre ex Beille // Corynanthe johimbe K.Schum.
- Family:
- Rubiaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 86
- Number of processed references:
- 7
Compositions
#1: phlobotannins in bark
#2: saponins in bark
#3: Anthraquinones in bark
#4: coumarins in bark
#5: tannins in bark
#6: beta-yohimbine in bark
#7: pseudoyohimbine in bark
#8: alpha-yohimbine in bark
#9: yohimbine in bark
#10: alpha-yohimbine in bark
#11: pseudoyohimbine in bark
#12: alloyohimbine in bark
#13: beta-yohimbine in bark
#14: 3-epi-α-yohimbine in bark
#15: yohimbine in bark
#16: 3-epialloyohimbine in bark
#17: pseudo-β-yohimbine in bark
#18: corynanthine in bark
#19: stereoisomers of yohimbine in bark
#20: Indole alkaloids in bark
#21: raubasine in bark
#22: yohimbine in bark
#23: aspidofractine in bark
#24: 5-Myristoyl-3-naphthamine in bark
#25: ajmalicine in bark
#26: corynanthine in bark
#27: Methyl-3-(3-oxo-1,2,3,5,6,11b-hexahydro-11hpyrrolo[ 2,1-a]-.beta. –carbolin-11b-yl) propionate in bark
#28: Yohimbine in bark
#29: Yohimban-16-carboxylic acid, 17-hydroxy-,methyl ester, (16.beta.,17.alpha.) in bark
#30: Beta-Yohimbine in bark
#31: Yohimban-16-carboxylic acid, 17-hydroxy-,methyl ester, (16.alpha.,17.beta.) in bark
#32: Bis[4-(2,5-dimethyl-1-pyrrolyl)phenyl] oxide in bark
#33: 1.alpha. –n-butyl-1.beta.–(2-methoxycarbonylethyl)- 1,2,3,4,6,7,12,12b.beta. –octahydroindolo[ 2,3-a]quinolizine in bark
#34: N,N'-Bis(fluoren-9-ylidene) hydrazine in bark
#35: ajmalicine in bark
#36: yohimbine in bark
Composition #1: Sodipo, Oluwole A., Akinniyi, John A., Ogunbameru, Josephine V. Studies on certain characteristics of extracts of bark of Pausinystalia johimbe and Pausinystalia macroceras (K.Schum.) Pierre ex Beille. global journal of pure and applied sciences, 2000, vol. 6, no. 1, p. 83–87. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
phlobotannins (RF-00011481-PAR)
-
Analytical method code:
Phytochemical screening (F604A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
phlobotannins in bark
Composition #2: Sodipo, Oluwole A., Akinniyi, John A., Ogunbameru, Josephine V. Studies on certain characteristics of extracts of bark of Pausinystalia johimbe and Pausinystalia macroceras (K.Schum.) Pierre ex Beille. global journal of pure and applied sciences, 2000, vol. 6, no. 1, p. 83–87. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
Saponins (RF-00004333-PAR)
-
Analytical method code:
Phytochemical screening (F604A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
saponins in bark
Composition #3: Sodipo, Oluwole A., Akinniyi, John A., Ogunbameru, Josephine V. Studies on certain characteristics of extracts of bark of Pausinystalia johimbe and Pausinystalia macroceras (K.Schum.) Pierre ex Beille. global journal of pure and applied sciences, 2000, vol. 6, no. 1, p. 83–87. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
Anthraquinone (RF-0475-001-PPP)
-
Analytical method code:
Phytochemical screening (F604A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Anthraquinones in bark
Composition #4: Sodipo, Oluwole A., Akinniyi, John A., Ogunbameru, Josephine V. Studies on certain characteristics of extracts of bark of Pausinystalia johimbe and Pausinystalia macroceras (K.Schum.) Pierre ex Beille. global journal of pure and applied sciences, 2000, vol. 6, no. 1, p. 83–87. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
coumarins (RF-00004351-PAR)
-
Analytical method code:
Phytochemical screening (F604A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
coumarins in bark
Composition #5: Sodipo, Oluwole A., Akinniyi, John A., Ogunbameru, Josephine V. Studies on certain characteristics of extracts of bark of Pausinystalia johimbe and Pausinystalia macroceras (K.Schum.) Pierre ex Beille. global journal of pure and applied sciences, 2000, vol. 6, no. 1, p. 83–87. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
Tannins (RF-00004337-PAR)
-
Analytical method code:
Phytochemical screening (F604A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
tannins in bark
Composition #6: Zanolari, Boris., Ndjoko, Karine., Ioset, Jean-Robert., Marston, Andrew., Hostettmann, Kurt. Qualitative and quantitative determination of yohimbine in authentic yohimbe bark and in commercial aphrodisiacs by HPLC-UV-API/MS methods. phytochemical analysis, 2003, vol. 14, no. 4, p. 193–201. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Additional extraction description:
unspecified
-
Substance:
beta-yohimbine (RF-00004180-PAR)
-
Analytical method code:
Unspecified (F598A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.03
-
Internal remarks:
beta-yohimbine in bark
Composition #7: Zanolari, Boris., Ndjoko, Karine., Ioset, Jean-Robert., Marston, Andrew., Hostettmann, Kurt. Qualitative and quantitative determination of yohimbine in authentic yohimbe bark and in commercial aphrodisiacs by HPLC-UV-API/MS methods. phytochemical analysis, 2003, vol. 14, no. 4, p. 193–201. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Additional extraction description:
unspecified
-
Substance:
pseudoyohimbine (RF-00003561-PAR)
-
Analytical method code:
Unspecified (F598A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.02 - 0.36
-
Internal remarks:
pseudoyohimbine in bark
Composition #8: Zanolari, Boris., Ndjoko, Karine., Ioset, Jean-Robert., Marston, Andrew., Hostettmann, Kurt. Qualitative and quantitative determination of yohimbine in authentic yohimbe bark and in commercial aphrodisiacs by HPLC-UV-API/MS methods. phytochemical analysis, 2003, vol. 14, no. 4, p. 193–201. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Additional extraction description:
unspecified
-
Substance:
alpha-yohimbine (RF-00004110-PAR)
-
Analytical method code:
Unspecified (F598A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.39 - 0.46
-
Internal remarks:
alpha-yohimbine in bark
Composition #9: Zanolari, Boris., Ndjoko, Karine., Ioset, Jean-Robert., Marston, Andrew., Hostettmann, Kurt. Qualitative and quantitative determination of yohimbine in authentic yohimbe bark and in commercial aphrodisiacs by HPLC-UV-API/MS methods. phytochemical analysis, 2003, vol. 14, no. 4, p. 193–201. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Additional extraction description:
unspecified
-
Substance:
yohimbine (RF-00003565-PAR)
-
Analytical method code:
Unspecified (F598A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.8 - 2.24
-
Internal remarks:
yohimbine in bark
Composition #10: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ammonium hydroxide / methanol - water
-
Substance:
alpha-yohimbine (RF-00004110-PAR)
-
Analytical method code:
HPLC hypenated to element spectrometry (F356A)
-
Analytical method - additional description:
UPLC/MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
alpha-yohimbine in bark
Composition #11: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ammonium hydroxide / methanol - water
-
Substance:
pseudoyohimbine (RF-00003561-PAR)
-
Analytical method code:
HPLC hypenated to element spectrometry (F356A)
-
Analytical method - additional description:
UPLC/MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
pseudoyohimbine in bark
Composition #12: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ammonium hydroxide / methanol - water
-
Substance:
alloyohimbine (RF-00004137-PAR)
-
Analytical method code:
HPLC hypenated to element spectrometry (F356A)
-
Analytical method - additional description:
UPLC/MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
alloyohimbine in bark
Composition #13: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ammonium hydroxide / methanol - water
-
Substance:
beta-yohimbine (RF-00004180-PAR)
-
Analytical method code:
HPLC hypenated to element spectrometry (F356A)
-
Analytical method - additional description:
UPLC/MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
beta-yohimbine in bark
Composition #14: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ammonium hydroxide / methanol - water
-
Substance:
yohimbine (RF-00003565-PAR)
-
Additional substance description:
3-epi-α-yohimbine
-
Analytical method code:
HPLC hypenated to element spectrometry (F356A)
-
Analytical method - additional description:
UPLC/MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
3-epi-α-yohimbine in bark
Composition #15: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ammonium hydroxide / methanol - water
-
Substance:
yohimbine (RF-00003565-PAR)
-
Analytical method code:
HPLC hypenated to element spectrometry (F356A)
-
Analytical method - additional description:
UPLC/MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
yohimbine in bark
Composition #16: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ammonium hydroxide / methanol - water
-
Substance:
indole alkaloids (RF-00004503-PAR)
-
Additional substance description:
3-epialloyohimbine
-
Analytical method code:
HPLC hypenated to element spectrometry (F356A)
-
Analytical method - additional description:
UPLC/MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
3-epialloyohimbine in bark
Composition #17: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ammonium hydroxide / methanol - water
-
Substance:
yohimbine (RF-00003565-PAR)
-
Additional substance description:
pseudo-β-yohimbine
-
Analytical method code:
HPLC hypenated to element spectrometry (F356A)
-
Analytical method - additional description:
UPLC/MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
pseudo-β-yohimbine in bark
Composition #18: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ammonium hydroxide / methanol - water
-
Substance:
corynanthine (RF-00004226-PAR)
-
Analytical method code:
HPLC hypenated to element spectrometry (F356A)
-
Analytical method - additional description:
UPLC/MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
corynanthine in bark
Composition #19: Aguilar, Fernando., Crebelli, Riccardo., Dusemund, Birgit., Galtier, Pierre., Gott, David., Gundert-Remy, Ursula., Konig, Jurgen., Lambre, Claude., Leblanc, Jean-Charles., Mosesso, Pasquale., . Scientific Opinion on the evaluation of the safety in use of Yohimbe (Pausinystalia yohimbe (K. Schum.) Pierre ex Beille). efsa journal, 2013, vol. 11, no. 7), 330, p. 46 pp. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Additional extraction description:
unspecified
-
Substance:
yohimbine (RF-00003565-PAR)
-
Additional substance description:
stereoisomers of yohimbine
-
Analytical method code:
Unspecified (F598A)
-
Result unit:
Milligram/gram (G060A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.2 - 4.6
-
Internal remarks:
stereoisomers of yohimbine in bark
Composition #20: Aguilar, Fernando., Crebelli, Riccardo., Dusemund, Birgit., Galtier, Pierre., Gott, David., Gundert-Remy, Ursula., Konig, Jurgen., Lambre, Claude., Leblanc, Jean-Charles., Mosesso, Pasquale., . Scientific Opinion on the evaluation of the safety in use of Yohimbe (Pausinystalia yohimbe (K. Schum.) Pierre ex Beille). efsa journal, 2013, vol. 11, no. 7), 330, p. 46 pp. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Additional extraction description:
unspecified
-
Substance:
indole alkaloids (RF-00004503-PAR)
-
Analytical method code:
Unspecified (F598A)
-
Result unit:
Milligram/gram (G060A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
2 - 150
-
Internal remarks:
Indole alkaloids in bark
Composition #21: Aguilar, Fernando., Crebelli, Riccardo., Dusemund, Birgit., Galtier, Pierre., Gott, David., Gundert-Remy, Ursula., Konig, Jurgen., Lambre, Claude., Leblanc, Jean-Charles., Mosesso, Pasquale., . Scientific Opinion on the evaluation of the safety in use of Yohimbe (Pausinystalia yohimbe (K. Schum.) Pierre ex Beille). efsa journal, 2013, vol. 11, no. 7), 330, p. 46 pp. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Additional extraction description:
unspecified
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Additional substance description:
raubasine
-
Analytical method code:
Unspecified (F598A)
-
Result unit:
Milligram/gram (G060A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.4
-
Internal remarks:
raubasine in bark
Composition #22: Aguilar, Fernando., Crebelli, Riccardo., Dusemund, Birgit., Galtier, Pierre., Gott, David., Gundert-Remy, Ursula., Konig, Jurgen., Lambre, Claude., Leblanc, Jean-Charles., Mosesso, Pasquale., . Scientific Opinion on the evaluation of the safety in use of Yohimbe (Pausinystalia yohimbe (K. Schum.) Pierre ex Beille). efsa journal, 2013, vol. 11, no. 7), 330, p. 46 pp. .
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Additional extraction description:
unspecified
-
Substance:
yohimbine (RF-00003565-PAR)
-
Analytical method code:
Unspecified (F598A)
-
Result unit:
Milligram/gram (G060A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
10
-
Internal remarks:
yohimbine in bark
Composition #23: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Additional substance description:
aspidofractine
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
1.11
-
Internal remarks:
aspidofractine in bark
Composition #24: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Additional substance description:
5-Myristoyl-3-naphthamine
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
3.02
-
Internal remarks:
5-Myristoyl-3-naphthamine in bark
Composition #25: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
Ajmalicine (RF-00003669-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
2.16
-
Internal remarks:
ajmalicine in bark
Composition #26: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
corynanthine (RF-00004226-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.30
-
Internal remarks:
corynanthine in bark
Composition #27: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Additional substance description:
Methyl-3-(3-oxo-1,2,3,5,6,11b-hexahydro-11hpyrrolo[ 2,1-a]-.beta. –carbolin-11b-yl) propionate
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.93
-
Internal remarks:
Methyl-3-(3-oxo-1,2,3,5,6,11b-hexahydro-11hpyrrolo[ 2,1-a]-.beta. –carbolin-11b-yl) propionate in bark
Composition #28: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
yohimbine (RF-00003565-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
62.26
-
Internal remarks:
Yohimbine in bark
Composition #29: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
yohimbine (RF-00003565-PAR)
-
Additional substance description:
Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16.beta.,17.alpha.)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
8.61
-
Internal remarks:
Yohimban-16-carboxylic acid, 17-hydroxy-,methyl ester, (16.beta.,17.alpha.) in bark
Composition #30: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
beta-yohimbine (RF-00004180-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
9.33
-
Internal remarks:
Beta-Yohimbine in bark
Composition #31: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
yohimbine (RF-00003565-PAR)
-
Additional substance description:
Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16.alpha.,17.beta.)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
6.24
-
Internal remarks:
Yohimban-16-carboxylic acid, 17-hydroxy-,methyl ester, (16.alpha.,17.beta.) in bark
Composition #32: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Additional substance description:
Bis[4-(2,5-dimethyl-1-pyrrolyl)phenyl] oxide
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
1.92
-
Internal remarks:
Bis[4-(2,5-dimethyl-1-pyrrolyl)phenyl] oxide in bark
Composition #33: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Additional substance description:
1.alpha. –n-butyl-1.beta.–(2-methoxycarbonylethyl)- 1,2,3,4,6,7,12,12b.beta. –octahydroindolo[ 2,3-a]quinolizine
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
3.74
-
Internal remarks:
1.alpha. –n-butyl-1.beta.–(2-methoxycarbonylethyl)- 1,2,3,4,6,7,12,12b.beta. –octahydroindolo[ 2,3-a]quinolizine in bark
Composition #34: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Methanol
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Additional substance description:
N,N'-Bis(fluoren-9-ylidene) hydrazine
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.37
-
Internal remarks:
N,N'-Bis(fluoren-9-ylidene) hydrazine in bark
Composition #35: Lucas, Derick., Neal-Kababick, James., Zweigenbaum, Jerry. Characterization and Quantitation of Yohimbine and Its Analogs in Botanicals and Dietary Supplements Using LC/QTOF-MS and LC/QQQ-MS for Determination of the Presence of Bark Extract and Yohimbine Adulteration . journal of aoac international, 2015, vol. 98, no. 2, p. 330–335. DOI: 10.5740/jaoacint.14-246.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol / formic acid
-
Substance:
Ajmalicine (RF-00003669-PAR)
-
Analytical method code:
LC-MS (F026A)
-
Analytical method - additional description:
LC/MS/MS with QQQ mass spectrometer
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
1.6 - 2.4
-
Internal remarks:
ajmalicine in bark
Composition #36: Lucas, Derick., Neal-Kababick, James., Zweigenbaum, Jerry. Characterization and Quantitation of Yohimbine and Its Analogs in Botanicals and Dietary Supplements Using LC/QTOF-MS and LC/QQQ-MS for Determination of the Presence of Bark Extract and Yohimbine Adulteration . journal of aoac international, 2015, vol. 98, no. 2, p. 330–335. DOI: 10.5740/jaoacint.14-246.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol / formic acid
-
Substance:
yohimbine (RF-00003565-PAR)
-
Analytical method code:
LC-MS (F026A)
-
Analytical method - additional description:
LC/MS/MS with QQQ mass spectrometer
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.3 - 1.1
-
Internal remarks:
yohimbine in bark
Endpoint study
#1: Cotten, Steven W., Hammett-Stabler, Catherine A. Risk of toxicity associated with unregulated herbal products. herbal supplements, 2011, p. 45–72. .
-
Study relevance:
Human health
-
Plant part:
Bark (as part-nature) (A066X)
-
Type of toxicological test:
case report (CHD060TT)
-
Tested organism:
Human (as organism) (A056J)
-
-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
-
-
Unit of exposure duration:
Hour (G099A)
-
Number of organisms dosed:
1
-
-
Endpoint measured:
Dose level (CHD014EP)
-
Concentration unit:
Gram (G148A)
-
-
Critical effect:
SYSTEMIC (TOX01A)
-
Target tissue:
Neurologic (TT004A)
-
Effect description:
Malaise, vomiting, loss of consciousness, and repeated seizures after ingesting 5 g of yohimbine bark extract
-
Effect or parameter linked to the endpoint:
neurology (CHD027BE)
-
Internal remarks:
malaise, vomiting, loss of consciousness, and repeated seizures in human
Endpoint study
#2: Aguilar, Fernando., Crebelli, Riccardo., Dusemund, Birgit., Galtier, Pierre., Gott, David., Gundert-Remy, Ursula., Konig, Jurgen., Lambre, Claude., Leblanc, Jean-Charles., Mosesso, Pasquale., . Scientific Opinion on the evaluation of the safety in use of Yohimbe (Pausinystalia yohimbe (K. Schum.) Pierre ex Beille). efsa journal, 2013, vol. 11, no. 7), 330, p. 46 pp. .
-
Study relevance:
Human health
-
Plant part:
Bark (as part-nature) (A066X)
-
Type of toxicological test:
case report (CHD060TT)
-
Limit test:
Not applicable
-
Tested organism:
Human (as organism) (A056J)
-
-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
SYSTEMIC (TOX01A)
-
Effect description:
hypertensive crisis, manic symptoms, anxiety, agitation, loss of consciousness
-
Effect or parameter linked to the endpoint:
behaviour (CHD001BE)
-
Internal remarks:
hypertensive crisis, manic symptoms, anxiety, agitation, loss of consciousness in humans
Endpoint study
#3: Aguilar, Fernando., Crebelli, Riccardo., Dusemund, Birgit., Galtier, Pierre., Gott, David., Gundert-Remy, Ursula., Konig, Jurgen., Lambre, Claude., Leblanc, Jean-Charles., Mosesso, Pasquale., . Scientific Opinion on the evaluation of the safety in use of Yohimbe (Pausinystalia yohimbe (K. Schum.) Pierre ex Beille). efsa journal, 2013, vol. 11, no. 7), 330, p. 46 pp. .
-
Study relevance:
Human health
-
Plant part:
Bark (as part-nature) (A066X)
-
Type of toxicological test:
case report (CHD060TT)
-
Limit test:
Not applicable
-
Tested organism:
Human (as organism) (A056J)
-
-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
-
Control groups used:
no data
-
Endpoint measured:
Lowest observable effect level (CHD028EP)
-
Concentration unit:
Milligram (G155A)
-
-
Critical effect:
SYSTEMIC (TOX01A)
-
Target tissue:
cardiovascular / haematological: Heart (TT011A)
-
Effect description:
moderately but significantly accelerated supine heart rate
-
Effect or parameter linked to the endpoint:
other (CHD003BE)
-
Internal remarks:
moderately but significantly accelerated supine heart rate in humans