EFSA
ecomole
vscht
  2. Pausinystalia johimbe (K.Schum.) Pierre ex Beille // Corynanthe johimbe K.Schum.

Pausinystalia johimbe (K.Schum.) Pierre ex Beille // Corynanthe johimbe K.Schum.

Family:
Rubiaceae
Approval state:
Approved
Number of articles retrieved:
86
Number of processed references:
7
Compositions
#1: phlobotannins in bark #2: saponins in bark #3: Anthraquinones in bark #4: coumarins in bark #5: tannins in bark #6: beta-yohimbine in bark #7: pseudoyohimbine in bark #8: alpha-yohimbine in bark #9: yohimbine in bark #10: alpha-yohimbine in bark #11: pseudoyohimbine in bark #12: alloyohimbine in bark #13: beta-yohimbine in bark #14: 3-epi-α-yohimbine in bark #15: yohimbine in bark #16: 3-epialloyohimbine in bark #17: pseudo-β-yohimbine in bark #18: corynanthine in bark #19: stereoisomers of yohimbine in bark #20: Indole alkaloids in bark #21: raubasine in bark #22: yohimbine in bark #23: aspidofractine in bark #24: 5-Myristoyl-3-naphthamine in bark #25: ajmalicine in bark #26: corynanthine in bark #27: Methyl-3-(3-oxo-1,2,3,5,6,11b-hexahydro-11hpyrrolo[ 2,1-a]-.beta. –carbolin-11b-yl) propionate in bark #28: Yohimbine in bark #29: Yohimban-16-carboxylic acid, 17-hydroxy-,methyl ester, (16.beta.,17.alpha.) in bark #30: Beta-Yohimbine in bark #31: Yohimban-16-carboxylic acid, 17-hydroxy-,methyl ester, (16.alpha.,17.beta.) in bark #32: Bis[4-(2,5-dimethyl-1-pyrrolyl)phenyl] oxide in bark #33: 1.alpha. –n-butyl-1.beta.–(2-methoxycarbonylethyl)- 1,2,3,4,6,7,12,12b.beta. –octahydroindolo[ 2,3-a]quinolizine in bark #34: N,N'-Bis(fluoren-9-ylidene) hydrazine in bark #35: ajmalicine in bark #36: yohimbine in bark
Endpoint Studies
#1: malaise, vomiting, loss of consciousness, and repeated seizures in human #2: hypertensive crisis, manic symptoms, anxiety, agitation, loss of consciousness in humans #3: moderately but significantly accelerated supine heart rate in humans
Genotoxicity
Composition #1: Sodipo, Oluwole A., Akinniyi, John A., Ogunbameru, Josephine V. Studies on certain characteristics of extracts of bark of Pausinystalia johimbe and Pausinystalia macroceras (K.Schum.) Pierre ex Beille. global journal of pure and applied sciences, 2000, vol. 6, no. 1, p. 83–87. .
Composition #2: Sodipo, Oluwole A., Akinniyi, John A., Ogunbameru, Josephine V. Studies on certain characteristics of extracts of bark of Pausinystalia johimbe and Pausinystalia macroceras (K.Schum.) Pierre ex Beille. global journal of pure and applied sciences, 2000, vol. 6, no. 1, p. 83–87. .
Composition #3: Sodipo, Oluwole A., Akinniyi, John A., Ogunbameru, Josephine V. Studies on certain characteristics of extracts of bark of Pausinystalia johimbe and Pausinystalia macroceras (K.Schum.) Pierre ex Beille. global journal of pure and applied sciences, 2000, vol. 6, no. 1, p. 83–87. .
Composition #4: Sodipo, Oluwole A., Akinniyi, John A., Ogunbameru, Josephine V. Studies on certain characteristics of extracts of bark of Pausinystalia johimbe and Pausinystalia macroceras (K.Schum.) Pierre ex Beille. global journal of pure and applied sciences, 2000, vol. 6, no. 1, p. 83–87. .
Composition #5: Sodipo, Oluwole A., Akinniyi, John A., Ogunbameru, Josephine V. Studies on certain characteristics of extracts of bark of Pausinystalia johimbe and Pausinystalia macroceras (K.Schum.) Pierre ex Beille. global journal of pure and applied sciences, 2000, vol. 6, no. 1, p. 83–87. .
Composition #6: Zanolari, Boris., Ndjoko, Karine., Ioset, Jean-Robert., Marston, Andrew., Hostettmann, Kurt. Qualitative and quantitative determination of yohimbine in authentic yohimbe bark and in commercial aphrodisiacs by HPLC-UV-API/MS methods. phytochemical analysis, 2003, vol. 14, no. 4, p. 193–201. .
Composition #7: Zanolari, Boris., Ndjoko, Karine., Ioset, Jean-Robert., Marston, Andrew., Hostettmann, Kurt. Qualitative and quantitative determination of yohimbine in authentic yohimbe bark and in commercial aphrodisiacs by HPLC-UV-API/MS methods. phytochemical analysis, 2003, vol. 14, no. 4, p. 193–201. .
Composition #8: Zanolari, Boris., Ndjoko, Karine., Ioset, Jean-Robert., Marston, Andrew., Hostettmann, Kurt. Qualitative and quantitative determination of yohimbine in authentic yohimbe bark and in commercial aphrodisiacs by HPLC-UV-API/MS methods. phytochemical analysis, 2003, vol. 14, no. 4, p. 193–201. .
Composition #9: Zanolari, Boris., Ndjoko, Karine., Ioset, Jean-Robert., Marston, Andrew., Hostettmann, Kurt. Qualitative and quantitative determination of yohimbine in authentic yohimbe bark and in commercial aphrodisiacs by HPLC-UV-API/MS methods. phytochemical analysis, 2003, vol. 14, no. 4, p. 193–201. .
Composition #10: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
Composition #11: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
Composition #12: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
Composition #13: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
Composition #14: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
Composition #15: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
Composition #16: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
Composition #17: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
Composition #18: Sun, Jianghao., Baker, Andrew., Chen, Pei. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. rapid communications in mass spectrometry, 2011, vol. 25, no. 18, p. 2591–2602. .
Composition #19: Aguilar, Fernando., Crebelli, Riccardo., Dusemund, Birgit., Galtier, Pierre., Gott, David., Gundert-Remy, Ursula., Konig, Jurgen., Lambre, Claude., Leblanc, Jean-Charles., Mosesso, Pasquale., . Scientific Opinion on the evaluation of the safety in use of Yohimbe (Pausinystalia yohimbe (K. Schum.) Pierre ex Beille). efsa journal, 2013, vol. 11, no. 7), 330, p. 46 pp. .
Composition #20: Aguilar, Fernando., Crebelli, Riccardo., Dusemund, Birgit., Galtier, Pierre., Gott, David., Gundert-Remy, Ursula., Konig, Jurgen., Lambre, Claude., Leblanc, Jean-Charles., Mosesso, Pasquale., . Scientific Opinion on the evaluation of the safety in use of Yohimbe (Pausinystalia yohimbe (K. Schum.) Pierre ex Beille). efsa journal, 2013, vol. 11, no. 7), 330, p. 46 pp. .
Composition #21: Aguilar, Fernando., Crebelli, Riccardo., Dusemund, Birgit., Galtier, Pierre., Gott, David., Gundert-Remy, Ursula., Konig, Jurgen., Lambre, Claude., Leblanc, Jean-Charles., Mosesso, Pasquale., . Scientific Opinion on the evaluation of the safety in use of Yohimbe (Pausinystalia yohimbe (K. Schum.) Pierre ex Beille). efsa journal, 2013, vol. 11, no. 7), 330, p. 46 pp. .
Composition #22: Aguilar, Fernando., Crebelli, Riccardo., Dusemund, Birgit., Galtier, Pierre., Gott, David., Gundert-Remy, Ursula., Konig, Jurgen., Lambre, Claude., Leblanc, Jean-Charles., Mosesso, Pasquale., . Scientific Opinion on the evaluation of the safety in use of Yohimbe (Pausinystalia yohimbe (K. Schum.) Pierre ex Beille). efsa journal, 2013, vol. 11, no. 7), 330, p. 46 pp. .
Composition #23: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055. [DOI link]
Composition #24: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055. [DOI link]
Composition #25: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055. [DOI link]
Composition #26: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055. [DOI link]
Composition #27: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055. [DOI link]
Composition #28: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055. [DOI link]
Composition #29: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055. [DOI link]
Composition #30: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055. [DOI link]
Composition #31: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055. [DOI link]
Composition #32: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055. [DOI link]
Composition #33: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055. [DOI link]
Composition #34: Chen, Qinhua., Lil, Peng., Zhang, Zhuo., Lil, Kaijun., Liu, Jia., Li, Qiang. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry . journal of separation science, 2008, vol. 31, no. 12, p. 2211–2218. DOI: 10.1002/jssc.200800055. [DOI link]
Composition #35: Lucas, Derick., Neal-Kababick, James., Zweigenbaum, Jerry. Characterization and Quantitation of Yohimbine and Its Analogs in Botanicals and Dietary Supplements Using LC/QTOF-MS and LC/QQQ-MS for Determination of the Presence of Bark Extract and Yohimbine Adulteration . journal of aoac international, 2015, vol. 98, no. 2, p. 330–335. DOI: 10.5740/jaoacint.14-246. [DOI link]
Composition #36: Lucas, Derick., Neal-Kababick, James., Zweigenbaum, Jerry. Characterization and Quantitation of Yohimbine and Its Analogs in Botanicals and Dietary Supplements Using LC/QTOF-MS and LC/QQQ-MS for Determination of the Presence of Bark Extract and Yohimbine Adulteration . journal of aoac international, 2015, vol. 98, no. 2, p. 330–335. DOI: 10.5740/jaoacint.14-246. [DOI link]
Endpoint study #1: Cotten, Steven W., Hammett-Stabler, Catherine A. Risk of toxicity associated with unregulated herbal products. herbal supplements, 2011, p. 45–72. .
Endpoint study #2: Aguilar, Fernando., Crebelli, Riccardo., Dusemund, Birgit., Galtier, Pierre., Gott, David., Gundert-Remy, Ursula., Konig, Jurgen., Lambre, Claude., Leblanc, Jean-Charles., Mosesso, Pasquale., . Scientific Opinion on the evaluation of the safety in use of Yohimbe (Pausinystalia yohimbe (K. Schum.) Pierre ex Beille). efsa journal, 2013, vol. 11, no. 7), 330, p. 46 pp. .
Endpoint study #3: Aguilar, Fernando., Crebelli, Riccardo., Dusemund, Birgit., Galtier, Pierre., Gott, David., Gundert-Remy, Ursula., Konig, Jurgen., Lambre, Claude., Leblanc, Jean-Charles., Mosesso, Pasquale., . Scientific Opinion on the evaluation of the safety in use of Yohimbe (Pausinystalia yohimbe (K. Schum.) Pierre ex Beille). efsa journal, 2013, vol. 11, no. 7), 330, p. 46 pp. .