Composition #1: Kelly, Edgar A., Lynn, E. V. Chemical study of Senecio aureus. journal of the american pharmaceutical association (1912-1977), 1931, vol. 20, p. 755–9. .
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:
Positive/Present (POS)
Result type:
Qualitative Value (Binary) (BIN)
Internal remarks:
alkaloids
Composition #2: NACHMAN, RJ. TETRAHYDROLIGULARENOLIDE AND RELATED EREMOPHILANES FROM SENECIO-AUREUS. phytochemistry, 1983, vol. 22, no. 3, p. 780–782. DOI: 10.1016/S0031-9422(00)86987-3.
[DOI link]
Language:
English (en)
Plant part:
Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:
Solvent extraction (A0BZR)
Additional extraction description:
F-Et2O, F-Et2O-C6H6
Substance:
sesquiterpene alkaloids (RF-00004371-PAR)
Additional substance description:
tetrahydroligularenolide, furanoeremophilane, ligularenolide, and dehydrofukinone.
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:
GC, NMR
Yes/No Qualitative:
Positive/Present (POS)
Result type:
Qualitative Value (Binary) (BIN)
Internal remarks:
tetrahydroligularenolide, furanoeremophilane, ligularenolide, and dehydrofukinone.
Composition #3: RESCH, JF., GOLDSTEIN, SA., MEINWALD, J. OTOSENINE FROM SENECIO-AUREUS. planta medica, 1983, vol. 47, no. 4, p. 255–255. DOI: 10.1055/s-2007-970005.
[DOI link]
Language:
English (en)
Plant part:
Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:
Solvent extraction (A0BZR)
Additional extraction description:
unspecified
Substance:
Otosenine (RF-00000292-TOX)
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:
column chromatography
Yes/No Qualitative:
Positive/Present (POS)
Result type:
Qualitative Value (Binary) (BIN)
Internal remarks:
otosenine in aerial parts
Endpoint study
#1: Osuigwe, M.J., Margret, N. Evaluation of the toxicological effects of Senecio aureus extract on the liver and hematological parameters in wistar rats. jordan journal of biological sciences, 2017, vol. 10, no. 1, p. 29–32. .
Study relevance:
Human health
Plant part:
Live plants (as part-nature) (A0BA0)
Preparation/Extraction method:
Solvent extraction (A0BZR)
Additional plant/substance description:
ethanol 70%
Type of toxicological test:
short-term toxicity (CHD017TT)
Limit test:
No
Tested organism:
Rat (as animal) (A0CNV)
Strain of test organism:
Wistar (CHD013ST)
Sex:
Male
Exposure duration:
28.0
Unit of exposure duration:
Day (G134A)
Number of organisms dosed:
4
Control groups used:
yes
Endpoint measured:
Dose level (CHD014EP)
Concentration unit:
Milligrams per kilogram body weight (G225A)
Effect concentration:
500
Critical effect:
HEPATOTOXICITY (TOX02A)
Target tissue:
digestive: Liver (TT023A)
Effect description:
increased total bilirubin and cholesterol, decresed body weight gain
