EFSA Compendium of Botanicals

Draft - work in progress

Turpeth (as plant) // Ipomoea turpethum (L.) R.Br. // Operculina turpethum (L.) Silva Manso

Family:: Convolvulaceae
Approval state:: Approved
Number of articles retrieved:: 152
Number of processed references:: 6

Compositions

#1: N-p-comaryltyramine in stem #2: 22, 23-dihydro-alpha-spinasteryl-beta-D glucoside in stem #3: salicylic acid in stem #4: tannins in roots #5: alkaloids in roots #6: cardiac glycosides in roots #7: saponins in roots #8: Stigma- 5,22dien-3-O-b-D-glucopyranoside in roots #9: coumarins in seeds #10: salicylic acid in stem #11: coumarins in root bark #12: scopoletin in resin #13: Saponins: operculinoside A, operculinoside B, operculinoside C, operculinoside D in aerial parts #14: salicylic acid in leaves #15: gallic acid in leaves #16: coumarin in leaves

Endpoint Studies

Genotoxicity

Composition #1: Harun-Or-Rashid, Md., Abdul Gafur, Md., Sarker, Md. Moklesur Rahman., Karim, Nurul. A spinasteryl glycoside from Ipomoea Turpethum L. herb (STEM) growing in Bangladesh. journal of bangladesh academy of sciences, 2012, vol. 36, no. 1, p. 13–17. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

N-P-Coumaroyltyramine N-P-Coumaroyltyramine (RF-00010849-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

N-p-comaryltyramine in stem

Composition #2: Harun-Or-Rashid, Md., Abdul Gafur, Md., Sarker, Md. Moklesur Rahman., Karim, Nurul. A spinasteryl glycoside from Ipomoea Turpethum L. herb (STEM) growing in Bangladesh. journal of bangladesh academy of sciences, 2012, vol. 36, no. 1, p. 13–17. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

spinasterol (RF-00000397-NTR)
Additional substance description:

22, 23-dihydro-alpha-spinasteryl-beta-D glucoside
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

22, 23-dihydro-alpha-spinasteryl-beta-D glucoside in stem

Composition #3: Harun-Or-Rashid, Md., Abdul Gafur, Md., Sarker, Md. Moklesur Rahman., Karim, Nurul. A spinasteryl glycoside from Ipomoea Turpethum L. herb (STEM) growing in Bangladesh. journal of bangladesh academy of sciences, 2012, vol. 36, no. 1, p. 13–17. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Salicylic acid (RF-00000241-VET)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

salicylic acid in stem

Composition #4: Sharma, V., Singh, M. Comparative analysis of the phytochemicals present in different extracts of Operculina turpethum. international journal of drug development and research, 2013, vol. 5, no. 2, p. 244–250. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum, benzene, chloroform, ethyl acetate, ethanol, aqua
Substance:

Tannins (RF-00004337-PAR)
Analytical method - additional description:

ferric chloride test, gelatin test, vanillin-HCl test
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tannins in roots

Composition #5: Sharma, V., Singh, M. Comparative analysis of the phytochemicals present in different extracts of Operculina turpethum. international journal of drug development and research, 2013, vol. 5, no. 2, p. 244–250. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum, benzene, chloroform, ethyl acetate, ethanol, aqua
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method - additional description:

Dragendroff’s test, Tannic acid t-est
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids in roots

Composition #6: Sharma, V., Singh, M. Comparative analysis of the phytochemicals present in different extracts of Operculina turpethum. international journal of drug development and research, 2013, vol. 5, no. 2, p. 244–250. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum, benzene, chloroform, ethyl acetate, ethanol, aqua
Substance:

cardiac glycosides (RF-00010823-PAR)
Analytical method - additional description:

Keller-Killiani test, Salkowski test
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cardiac glycosides in roots

Composition #7: Sharma, V., Singh, M. Comparative analysis of the phytochemicals present in different extracts of Operculina turpethum. international journal of drug development and research, 2013, vol. 5, no. 2, p. 244–250. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum, benzene, chloroform, ethyl acetate, ethanol, aqua
Substance:

Saponins (RF-00004333-PAR)
Analytical method - additional description:

Froth test
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins in roots

Composition #8: Sharma, V., Singh, M. Potential recovery from hepatotoxicity by Operculina turpethum and its isolated stigma-5,22dien-3-O-B-D-glucopyranoside against N- nitrosodimethylamine, a potent carcinogen in animal model. international journal of pharma and bio sciences, 2014, vol. 5, no. 2, p. P271–P284. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

steroidal glycosides (RF-00011482-PAR)
Additional substance description:

Stigma- 5,22dien-3-O-b-D-glucopyranoside
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Analytical method - additional description:

TLC, HPLC, NMR, LCMS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Stigma- 5,22dien-3-O-b-D-glucopyranoside in roots

Composition #9: Gupta, Shweta., Ved, Akash. Operculina turpethum (Linn.) Silva Manso as a Medicinal Plant Species: A Review on Bioactive Components and Pharmacological Properties. . pharmacognosy reviews, 2017, vol. 11, no. 22, p. 158–166. DOI: 10.4103/phrev.phrev_6_17. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Substance:

coumarins (RF-00004351-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.061-0.21
Internal remarks:

coumarins in seeds

Composition #10: Gupta, Shweta., Ved, Akash. Operculina turpethum (Linn.) Silva Manso as a Medicinal Plant Species: A Review on Bioactive Components and Pharmacological Properties. . pharmacognosy reviews, 2017, vol. 11, no. 22, p. 158–166. DOI: 10.4103/phrev.phrev_6_17. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

Salicylic acid (RF-00000241-VET)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

salicylic acid in stem

Composition #11: Gupta, Shweta., Ved, Akash. Operculina turpethum (Linn.) Silva Manso as a Medicinal Plant Species: A Review on Bioactive Components and Pharmacological Properties. . pharmacognosy reviews, 2017, vol. 11, no. 22, p. 158–166. DOI: 10.4103/phrev.phrev_6_17. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

root bark
Substance:

coumarins (RF-00004351-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.212-0.271
Internal remarks:

coumarins in root bark

Composition #12: Gupta, Shweta., Ved, Akash. Operculina turpethum (Linn.) Silva Manso as a Medicinal Plant Species: A Review on Bioactive Components and Pharmacological Properties. . pharmacognosy reviews, 2017, vol. 11, no. 22, p. 158–166. DOI: 10.4103/phrev.phrev_6_17. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Additional extraction description:

in resin
Substance:

scopoletin (RF-00004048-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

scopoletin in resin

Composition #13: Ding, Wenbing., Zeng, Fanli., Xu, Liangxiong., Chen, Yunyun., Wang, Yifei., Wei, Xiaoyi. Bioactive Dammarane-Type Saponins from Operculina turpethum. journal of natural products, 2011, vol. 74, no. 9, p. 1868–1874. DOI: 10.1021/np200274m. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 95%
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

operculinoside A - D
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

NMR, HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins: operculinoside A, operculinoside B, operculinoside C, operculinoside D in aerial parts

Composition #14: Jalaj, Anju Vijayakumari., Radhamany, Puthuparampil Madhavan. IDENTIFICATION AND QUANTIFICATION OF PHENOLIC COMPOUNDS FROM OPERCULINA TURPETHUM (L.) SILVA MANSO LEAF BY HPLC METHOD . international journal of pharmaceutical sciences and research, 2016, vol. 7, no. 4, p. 1656–1661. DOI: 10.13040/IJPSR.0975-8232.7(4).1656-61. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Salicylic acid (RF-00000241-VET)
Analytical method code:

HPLC-UV (F021A)
Result unit:

Milligram/millilitre (G191A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.28
Internal remarks:

salicylic acid in leaves

Composition #15: Jalaj, Anju Vijayakumari., Radhamany, Puthuparampil Madhavan. IDENTIFICATION AND QUANTIFICATION OF PHENOLIC COMPOUNDS FROM OPERCULINA TURPETHUM (L.) SILVA MANSO LEAF BY HPLC METHOD . international journal of pharmaceutical sciences and research, 2016, vol. 7, no. 4, p. 1656–1661. DOI: 10.13040/IJPSR.0975-8232.7(4).1656-61. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

HPLC-UV (F021A)
Result unit:

Milligram/millilitre (G191A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.15
Internal remarks:

gallic acid in leaves

Composition #16: Jalaj, Anju Vijayakumari., Radhamany, Puthuparampil Madhavan. IDENTIFICATION AND QUANTIFICATION OF PHENOLIC COMPOUNDS FROM OPERCULINA TURPETHUM (L.) SILVA MANSO LEAF BY HPLC METHOD . international journal of pharmaceutical sciences and research, 2016, vol. 7, no. 4, p. 1656–1661. DOI: 10.13040/IJPSR.0975-8232.7(4).1656-61. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Coumarin (RF-00000370-TOX)
Analytical method code:

HPLC-UV (F021A)
Result unit:

Milligram/millilitre (G191A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.34
Internal remarks:

coumarin in leaves