Composition #1: Dutta, Dipanwrta., Devi, S. Saravana., Krishnamurthi, K., Kumar, Koel., Vyas, Priyanka., Muthal, P. L., Naoghare, P., Chakrabarti, T. Modulatory effect of distillate of Ocimum sanctum leaf extract (Tulsi) on human lymphocytes against genotoxicants . biomedical and environmental sciences, 2007, vol. 20, no. 3, p. 226–234. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
distillation
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Substance:
Eugenol (RF-00003807-PAR)
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Analytical method code:
LC-MS (F026A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
eugenol - leaves
Composition #2: Kaewnarin, Khwanta., Rakariyatham, Nuansri. Inhibitory Effects of Phenolic Compounds in Ocimum sanctum Extract on the alpha-Glucosidase Activity and the Formation of Advanced Glycation End-products . chiang mai journal of science, 2017, vol. 44, no. 1, p. 203–214. .
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
hexane, ethanol extract
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Substance:
methyleugenol (RF-00003931-PAR)
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Analytical method code:
LC-MS (F026A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
methyleugenol
Endpoint study
#1: Pragya, S., Hembrom, A.R., Singh, V.N. Antifertility efficacy of aqueous leaf extract of Ocimum sanctum (Linn) on seminal LDH isozymes of mice. journal of advanced zoology, 2013, vol. 34, no. 1, p. 36–39. .
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Study relevance:
Human health
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Plant part:
Leaves (as part-nature) (A0EKT)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
water extract
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Type of toxicological test:
reproduction toxicity (CHD009TT)
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Tested organism:
House mouse (as animal) (A0CNT)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
REPRODUCTIVE (TOX05A)
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Target tissue:
urogenital: Testes (TT050A)
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Effect description:
adversely affect fertility in mice and showed antifertility effect
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Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
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Internal remarks:
Water extract of leaves adversely affect fertility in mice and showed antifertility effect
