Composition #1: Ozer, Janet., Eisner, Nadav., Ostrozhenkova, Elena., Bacher, Adelbert., Eisenreich, Wolfgang., Benharroch, Daniel., Golan-Goldhirsh, Avi., Gopas, Jacob. Nuphar lutea thioalkaloids inhibit the nuclear factor kappa B pathway, potentiate apoptosis and are synergistic with cisplatin and etoposide . cancer biology & therapy, 2009, vol. 8, no. 19, p. 1860–1868. .
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol 50%
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Substance:
Alkaloids (RF-00004360-PAR)
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Additional substance description:
nuphlutine
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
nuphlutine
Composition #2: Ozer, Janet., Eisner, Nadav., Ostrozhenkova, Elena., Bacher, Adelbert., Eisenreich, Wolfgang., Benharroch, Daniel., Golan-Goldhirsh, Avi., Gopas, Jacob. Nuphar lutea thioalkaloids inhibit the nuclear factor kappa B pathway, potentiate apoptosis and are synergistic with cisplatin and etoposide . cancer biology & therapy, 2009, vol. 8, no. 19, p. 1860–1868. .
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-
Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol 50%
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Substance:
nupharidine (RF-00003521-PAR)
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
nupharidine
Composition #3: CYBULSKI, J., BABEL, K., WOJTASIEWICZ, K., WROBEL, JT., MACLEAN, DB. NUPHACRISTINE - AN ALKALOID FROM NUPHAR-LUTEUM. phytochemistry, 1988, vol. 27, no. 10, p. 3339–3341. DOI: 10.1016/0031-9422(88)80065-7.
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Additional extraction description:
unspecified
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Substance:
nuphacristine (RF-00003956-PAR)
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
nuphacristine in rhizomes
Endpoint study
#1: AIRAKSINEN, MM., PEURA, P., ALAFOSSISALOKANGAS, L., ANTERE, S., LUKKARINEN, J., SAIKKONEN, M., STENBACK, F. TOXICITY OF PLANT-MATERIAL USED AS EMERGENCY FOOD DURING FAMINES IN FINLAND . journal of ethnopharmacology, 1986, vol. 18, no. 3, p. 273–296. DOI: 10.1016/0378-8741(86)90006-1.
[
DOI link]
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Study relevance:
Human health
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Preparation/Extraction method:
Drying (dehydration) (A07KG)
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Type of toxicological test:
short-term toxicity (CHD017TT)
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Limit test:
Not applicable
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Tested organism:
House mouse (as animal) (A0CNT)
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Strain of test organism:
NMRI (CHD004ST)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Week (G205A)
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Number of organisms dosed:
10
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Endpoint measured:
Concentration level (CHD013EP)
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Concentration unit:
Percent (G138A)
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
gastrointestinal symptoms, hypothermia, piloerection and tremor, decreased food consumption and body weight
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Effect or parameter linked to the endpoint:
food consumption (CHD007BE)
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Internal remarks:
gastrointestinal toxicity
Endpoint study
#2: AIRAKSINEN, MM., PEURA, P., ALAFOSSISALOKANGAS, L., ANTERE, S., LUKKARINEN, J., SAIKKONEN, M., STENBACK, F. TOXICITY OF PLANT-MATERIAL USED AS EMERGENCY FOOD DURING FAMINES IN FINLAND . journal of ethnopharmacology, 1986, vol. 18, no. 3, p. 273–296. DOI: 10.1016/0378-8741(86)90006-1.
[
DOI link]
-
Study relevance:
Human health
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Preparation/Extraction method:
Drying (dehydration) (A07KG)
-
Type of toxicological test:
short-term toxicity (CHD017TT)
-
Limit test:
Not applicable
-
Tested organism:
House mouse (as animal) (A0CNT)
-
Strain of test organism:
NMRI (CHD004ST)
-
-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
-
Unit of exposure duration:
Week (G205A)
-
Number of organisms dosed:
10
-
-
Endpoint measured:
Concentration level (CHD013EP)
-
Concentration unit:
Percent (G138A)
-
-
Critical effect:
SYSTEMIC (TOX01A)
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Effect description:
mortality
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Effect or parameter linked to the endpoint:
mortality (CHD010BE)
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Internal remarks:
mortality
Endpoint study
#3: AIRAKSINEN, MM., PEURA, P., ALAFOSSISALOKANGAS, L., ANTERE, S., LUKKARINEN, J., SAIKKONEN, M., STENBACK, F. TOXICITY OF PLANT-MATERIAL USED AS EMERGENCY FOOD DURING FAMINES IN FINLAND . journal of ethnopharmacology, 1986, vol. 18, no. 3, p. 273–296. DOI: 10.1016/0378-8741(86)90006-1.
[
DOI link]
-
Study relevance:
Human health
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Preparation/Extraction method:
Drying (dehydration) (A07KG)
-
Type of toxicological test:
short-term toxicity (CHD017TT)
-
Limit test:
Not applicable
-
Tested organism:
House mouse (as animal) (A0CNT)
-
Strain of test organism:
NMRI (CHD004ST)
-
-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
-
Unit of exposure duration:
Week (G205A)
-
Number of organisms dosed:
10
-
-
Endpoint measured:
Concentration level (CHD013EP)
-
Concentration unit:
Percent (G138A)
-
-
Critical effect:
NEPHROTOXICITY (TOX03A)
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Target tissue:
urogenital: Kidneys (TT046A)
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Effect description:
tubular changes in kidneys (tubular dilatation, some necrotic cells)
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Effect or parameter linked to the endpoint:
histopathology non neoplastic (CHD025BE)
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Internal remarks:
histopathological changes of kidneys
