EFSA Compendium of Botanicals

Draft - work in progress

Nierembergia veitchii Hook.

Family:: Solanaceae
Approval state:: Approved
Number of articles retrieved:: 32
Number of processed references:: 3

Compositions

Endpoint Studies

#1: Fertility reduced in rats #2: calcinosis in sheep #3: systemic mineralization in sheep

Genotoxicity

Endpoint study #1: Mello, JRB., Langeloh, A., Habermehl, G., Krebs, HC., Bastos, FC. Effect of calcinogenic plant extracts on rat fertility. arquivo brasileiro de medicina veterinaria e zootecnia, 1999, vol. 51, no. 5, p. 453–462. DOI: 10.1590/S0102-09351999000500011. [DOI link]

Study relevance:

Human health
Plant part:

Unspecified (A07XD)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male/Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

40.0
Unit of exposure duration:

Day (G134A)
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Gram/kilogram (G015A)
Effect concentration:

10
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

Urogenital (TT006A)
Effect description:

fertility reduced (25%)
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

Fertility reduced in rats

Endpoint study #2: Barros, SS., Gimeno, EJ. Cell differentiation and bone protein synthesis in the lungs of sheep with spontaneous calcinosis . journal of comparative pathology, 2000, vol. 123, no. 4, p. 270–277. DOI: 10.1053/jcpa.2000.0415. [DOI link]

Study relevance:

Animal (target species) health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Type of toxicological test:

case report (CHD060TT)
Limit test:

Not applicable
Tested organism:

Sheep (as animal) (A057G)
Sex:

No data
Route of exposure:

ORAL: FEED (OECD2230PL)
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

PULMONARY AND CARDIAC (TOX08A)
Target tissue:

respiratory: Lung (TT041A)
Effect description:

activation of fibroblasts and SMCs, increase in extracellular matrix and precipitation of calcium and other histological na immunohistochemical changes
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

calcinosis in sheep

Endpoint study #3: Rissi, Daniel R., Brown, Corrie C., Barros, Claudio S. L. Chronic and acute clinical manifestations associated with systemic mineralization caused by ingestion of Nierembergia veitchii in sheep in southern Brazil . small ruminant research, 2009, vol. 87, no. 1-3, p. 102–104. DOI: 10.1016/j.smallrumres.2009.09.035. [DOI link]

Study relevance:

Animal (target species) health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Sheep (as animal) (A057G)
Sex:

No data
Route of exposure:

ORAL: FEED (OECD2230PL)
Number of organisms dosed:

25
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

SYSTEMIC (TOX01A)
Target tissue:

respiratory: Lung (TT041A)
Effect description:

weight loss, stiff gait, tucked abdomen,kyphosis, recumbency, death, pulmonary edema, mineralization of several tissues
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

systemic mineralization in sheep