EFSA Compendium of Botanicals

Draft - work in progress

Nepeta tenuifolia Benth. // Schizonepeta tenuifolia (Benth.) Briq.

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 752
Number of processed references:: 4

Compositions

#1: pulegone in whole plant #2: menthone in whole plant #3: menthone, gc-ms #4: isomenthone, gc-ms #5: pulegone, gc-ms #6: cis-isopulegone, gc-ms #7: carvone, gc-ms #8: piperitone, gc-ms #9: pulegone, aerial parts, GC-MS-ESI #10: octanone, aerial parts, GC-MS-ESI #11: myrcene, aerial parts, GC-MS-ESI #12: menthone, aerial parts, GC-MS-ESI #13: menthofuran, aerial parts, GC-MS-ESI

Endpoint Studies

#1: LD50 mouse #2: LD50 rabit

Genotoxicity

Composition #1: Park, Il-Kwon., Kim, Lee-Sum., Choi, In-Ho., Lee, Yeon-Suk., Shin, Sang-Chul. Fumigant activity of plant essential oils and components from Schizonepeta tenuifolia against Lycoriella ingenua (Diptera : Sciaridae) . journal of economic entomology, 2006, vol. 99, no. 5, p. 1717–1721. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

(+)-pulegone (RF-00003398-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

43.3
Internal remarks:

pulegone in whole plant

Composition #2: Park, Il-Kwon., Kim, Lee-Sum., Choi, In-Ho., Lee, Yeon-Suk., Shin, Sang-Chul. Fumigant activity of plant essential oils and components from Schizonepeta tenuifolia against Lycoriella ingenua (Diptera : Sciaridae) . journal of economic entomology, 2006, vol. 99, no. 5, p. 1717–1721. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

menthone (RF-00011280-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

49.7
Internal remarks:

menthone in whole plant

Composition #3: Chun, Mi-Hee., Kim, Eun Kyung., Lee, Kang Ro., Jung, Jee H., Hong, Jongki. Quality control of Schizonepeta tenuifolia Briq by solid-phase microextraction gas chromatography/mass spectrometry and principal component analysis . microchemical journal, 2010, vol. 95, no. 1, p. 25–31. DOI: 10.1016/j.microc.2009.09.009. [DOI link]

Language:

English (en)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

solid phase microextraction SPME
Substance:

menthone (RF-00011280-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

14.32
Internal remarks:

menthone, gc-ms

Composition #4: Chun, Mi-Hee., Kim, Eun Kyung., Lee, Kang Ro., Jung, Jee H., Hong, Jongki. Quality control of Schizonepeta tenuifolia Briq by solid-phase microextraction gas chromatography/mass spectrometry and principal component analysis . microchemical journal, 2010, vol. 95, no. 1, p. 25–31. DOI: 10.1016/j.microc.2009.09.009. [DOI link]

Language:

English (en)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

solid phase microextraction SPME
Substance:

d,l-Isomenthone (RF-00010214-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.4
Internal remarks:

isomenthone, gc-ms

Composition #5: Chun, Mi-Hee., Kim, Eun Kyung., Lee, Kang Ro., Jung, Jee H., Hong, Jongki. Quality control of Schizonepeta tenuifolia Briq by solid-phase microextraction gas chromatography/mass spectrometry and principal component analysis . microchemical journal, 2010, vol. 95, no. 1, p. 25–31. DOI: 10.1016/j.microc.2009.09.009. [DOI link]

Language:

English (en)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

solid phase microextraction SPME
Substance:

(+)-pulegone (RF-00003398-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

47.73
Internal remarks:

pulegone, gc-ms

Composition #6: Chun, Mi-Hee., Kim, Eun Kyung., Lee, Kang Ro., Jung, Jee H., Hong, Jongki. Quality control of Schizonepeta tenuifolia Briq by solid-phase microextraction gas chromatography/mass spectrometry and principal component analysis . microchemical journal, 2010, vol. 95, no. 1, p. 25–31. DOI: 10.1016/j.microc.2009.09.009. [DOI link]

Language:

English (en)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

solid phase microextraction SPME
Substance:

cis-isopulegone (RF-00003746-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.19
Internal remarks:

cis-isopulegone, gc-ms

Composition #7: Chun, Mi-Hee., Kim, Eun Kyung., Lee, Kang Ro., Jung, Jee H., Hong, Jongki. Quality control of Schizonepeta tenuifolia Briq by solid-phase microextraction gas chromatography/mass spectrometry and principal component analysis . microchemical journal, 2010, vol. 95, no. 1, p. 25–31. DOI: 10.1016/j.microc.2009.09.009. [DOI link]

Language:

English (en)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

solid phase microextraction SPME
Substance:

Carvone (RF-0538-001-PPP)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.95
Internal remarks:

carvone, gc-ms

Composition #8: Chun, Mi-Hee., Kim, Eun Kyung., Lee, Kang Ro., Jung, Jee H., Hong, Jongki. Quality control of Schizonepeta tenuifolia Briq by solid-phase microextraction gas chromatography/mass spectrometry and principal component analysis . microchemical journal, 2010, vol. 95, no. 1, p. 25–31. DOI: 10.1016/j.microc.2009.09.009. [DOI link]

Language:

English (en)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

solid phase microextraction SPME
Substance:

l-Piperitone (RF-00007699-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.86
Internal remarks:

piperitone, gc-ms

Composition #9: Yu, Sheng., Chen, Yiwen., Zhang, Li., Shan, Mingqiu., Tang, Yuping., Ding, Anwei. Quantitative Comparative Analysis of the Bio-Active and Toxic Constituents of Leaves and Spikes of Schizonepeta tenuifolia at Different Harvesting Times . international journal of molecular sciences, 2011, vol. 12, no. 10, p. 6635–6644. DOI: 10.3390/ijms12106635. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

(+)-pulegone (RF-00003398-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

GC-MS-ESI
Result unit:

Milligram/gram (G060A)
Result expression:

Reconstituted product (B007A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

18.25-42.84
Internal remarks:

pulegone, aerial parts, GC-MS-ESI

Composition #10: Yu, Sheng., Chen, Yiwen., Zhang, Li., Shan, Mingqiu., Tang, Yuping., Ding, Anwei. Quantitative Comparative Analysis of the Bio-Active and Toxic Constituents of Leaves and Spikes of Schizonepeta tenuifolia at Different Harvesting Times . international journal of molecular sciences, 2011, vol. 12, no. 10, p. 6635–6644. DOI: 10.3390/ijms12106635. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

4-Octanone (RF-00009030-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

GC-MS-ESI
Result unit:

Milligram/gram (G060A)
Result expression:

Reconstituted product (B007A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.06-0.1
Internal remarks:

octanone, aerial parts, GC-MS-ESI

Composition #11: Yu, Sheng., Chen, Yiwen., Zhang, Li., Shan, Mingqiu., Tang, Yuping., Ding, Anwei. Quantitative Comparative Analysis of the Bio-Active and Toxic Constituents of Leaves and Spikes of Schizonepeta tenuifolia at Different Harvesting Times . international journal of molecular sciences, 2011, vol. 12, no. 10, p. 6635–6644. DOI: 10.3390/ijms12106635. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

GC-MS-ESI
Result unit:

Milligram/gram (G060A)
Result expression:

Reconstituted product (B007A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.17-0.33
Internal remarks:

myrcene, aerial parts, GC-MS-ESI

Composition #12: Yu, Sheng., Chen, Yiwen., Zhang, Li., Shan, Mingqiu., Tang, Yuping., Ding, Anwei. Quantitative Comparative Analysis of the Bio-Active and Toxic Constituents of Leaves and Spikes of Schizonepeta tenuifolia at Different Harvesting Times . international journal of molecular sciences, 2011, vol. 12, no. 10, p. 6635–6644. DOI: 10.3390/ijms12106635. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

menthone (RF-00011280-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

GC-MS-ESI
Result unit:

Milligram/gram (G060A)
Result expression:

Reconstituted product (B007A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.54-16.74
Internal remarks:

menthone, aerial parts, GC-MS-ESI

Composition #13: Yu, Sheng., Chen, Yiwen., Zhang, Li., Shan, Mingqiu., Tang, Yuping., Ding, Anwei. Quantitative Comparative Analysis of the Bio-Active and Toxic Constituents of Leaves and Spikes of Schizonepeta tenuifolia at Different Harvesting Times . international journal of molecular sciences, 2011, vol. 12, no. 10, p. 6635–6644. DOI: 10.3390/ijms12106635. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

menthofuran (RF-00003924-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

GC-MS-ESI
Result unit:

Milligram/gram (G060A)
Result expression:

Reconstituted product (B007A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.01-0.15
Internal remarks:

menthofuran, aerial parts, GC-MS-ESI

Endpoint study #1: Fung, D., Lau, CBS. Schizonepeta tenuifolia: Chemistry, pharmacology, and clinical applications . journal of clinical pharmacology, 2002, vol. 42, no. 1, p. 30–36. DOI: 10.1177/0091270002042001003. [DOI link]

Study relevance:

Human health
Type of toxicological test:

not reported (CHD015TT)
Tested organism:

House mouse (as animal) (A0CNT)
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Endpoint measured:

Dose producing lethality in 50% of experimental organisms (CHD024EP)
Concentration unit:

Grams per kilogram body weight (G226A)
Effect concentration:

2.652
Effect description:

lethality
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

LD50 mouse

Endpoint study #2: Fung, D., Lau, CBS. Schizonepeta tenuifolia: Chemistry, pharmacology, and clinical applications . journal of clinical pharmacology, 2002, vol. 42, no. 1, p. 30–36. DOI: 10.1177/0091270002042001003. [DOI link]

Study relevance:

Human health
Type of toxicological test:

not reported (CHD015TT)
Tested organism:

Rabbit (as animal) (A057T)
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Endpoint measured:

Dose producing lethality in 50% of experimental organisms (CHD024EP)
Concentration unit:

Grams per kilogram body weight (G226A)
Effect concentration:

1.945
Effect description:

lethality
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

LD50 rabit