EFSA Compendium of Botanicals

Draft - work in progress

Montanoa tomentosa Cerv.

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 133
Number of processed references:: 11

Compositions

#1: The flavonoid isoquercitrin in leaves #2: sesquiterpene lactones in aerial part #3: germacranolides in aerial part #4: montanol in leaves #5: zoapatanilide A, zoapatanolide B in leaves #6: zoapatanol in leaves #7: 5-hydroxytomencephalin in leaves #8: montacephalin in leaves #9: tomencephalin in leaves #10: zoapatol A, zoapatol B in leaves #11: zoapatanolide F in leaves #12: sesquiterpene lactones in aerial part #13: kauradienoic acid, monoginoic acid in leaves #14: kaurenoic acid

Endpoint Studies

#1: male sexual behavior expression after single dose #2: antifertility activity of crude extract in quinea pigs after single dose #3: antifertility activity of zoapatanol in quinea pigs after single dose #4: antifertility activity of crude extract in rats #5: antifertility activity of crude extract in mice

Genotoxicity

Composition #1: Oshima, Yoshiteru., Gordell, Geoffrey A., Fong, Harry H. S. Studies on zoapatle. III. Flavonoid glycosides from Montanoa tomentosa ssp. tomentosa. journal of natural products, 1986, vol. 49, no. 3, p. 551–2. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH at room temperature, and the residue, after evaporation of the solvent, was partitioned between EtOAc and H,O
Substance:

Isoquercitrin (RF-00010712-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0018
Internal remarks:

The flavonoid isoquercitrin in leaves

Composition #2: Braca, A., Cioffi, G., Morelli, I., Venturella, F., Pizza, C., De Tommasi, N. Two new sesquiterpene lactones from Montanoa tomentosa ssp microcephala. planta medica, 2001, vol. 67, no. 8, p. 774–776. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sesquiterpene lactones in aerial part

Composition #3: Braca, A., Cioffi, G., Morelli, I., Venturella, F., Pizza, C., De Tommasi, N. Two new sesquiterpene lactones from Montanoa tomentosa ssp microcephala. planta medica, 2001, vol. 67, no. 8, p. 774–776. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Germacranolide (RF-00011355-PAR)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

germacranolides in aerial part

Composition #4: KANOJIA, RM., WACHTER, MP., LEVINE, SD., ADAMS, RE., CHEN, R., CHIN, E., COTTER, ML., HIRSCH, AF., HUETTEMANN, R., KANE, VV., OSTROWSKI, P., SHAW, CJ., MATEOS, JL., NORIEGA, L., GUZMAN, A., MIJAREZ, A., TOVAR, L., SHEFTER, E. ISOLATION AND STRUCTURAL ELUCIDATION OF ZOAPATANOL AND MONTANOL, NOVEL OXEPANE DITERPENOIDS FROM THE MEXICAN PLANT ZOAPATLE (MONTANOA-TOMENTOSA) . journal of organic chemistry, 1982, vol. 47, no. 7, p. 1310–1319. DOI: 10.1021/jo00346a029. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

montanol (RF-00003501-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

GC, gel-permeation chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

montanol in leaves

Composition #5: QUIJANO, L., CALDERON, JS., GOMEZ, F., RIOS, T. ZOAPATANOLIDE-A AND ZOAPATANOLIDE-B, 2 NEW HELIANGOLIDES FROM MONTANOA-TOMENTOSA . phytochemistry, 1982, vol. 21, no. 8, p. 2041–2044. DOI: 10.1016/0031-9422(82)83039-2. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3
Substance:

guaianolides (RF-00010821-PAR)
Additional substance description:

zoapatanilide A, zoapatanolide B
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

zoapatanilide A, zoapatanolide B in leaves

Composition #6: MARCELLE, GB., BUNYAPRAPHATSARA, N., CORDELL, GA., FONG, HHS., NICOLAOU, KC., ZIPKIN, RE. STUDIES OF ZOAPATLE .1. THE EXTRACTION OF ZOAPATLE (MONTANOA-TOMENTOSA) AND THE IDENTIFICATION OF 21-NORMONTANOL AS THE INITIAL DECOMPOSITION PRODUCT OF ZOAPATANOL . journal of natural products, 1985, vol. 48, no. 5, p. 739–745. DOI: 10.1021/np50041a004. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane, C2H2, EtOAc, and EtOH, distilledH2O
Substance:

zoapatanol (RF-00003642-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

zoapatanol in leaves

Composition #7: TOPCU, G., CORDELL, GA., FARNSWORTH, NR., FONG, HHS. STUDIES ON ZOAPATLE .8. NOVEL CYTO-TOXIC SESQUITERPENE LACTONES FROM MONTANOA-TOMENTOSA SSP MICROCEPHALA . journal of pharmaceutical sciences, 1988, vol. 77, no. 6, p. 553–556. DOI: 10.1002/jps.2600770620. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOAc
Substance:

guaianolides (RF-00010821-PAR)
Additional substance description:

5-hydroxytomencephalin (guaianolide sesquiterpene)
Substance used for equivalence:

Sesquiterpene lactones (RF-00004319-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR, NMR, MS
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0027
Internal remarks:

5-hydroxytomencephalin in leaves

Composition #8: TOPCU, G., CORDELL, GA., FARNSWORTH, NR., FONG, HHS. STUDIES ON ZOAPATLE .8. NOVEL CYTO-TOXIC SESQUITERPENE LACTONES FROM MONTANOA-TOMENTOSA SSP MICROCEPHALA . journal of pharmaceutical sciences, 1988, vol. 77, no. 6, p. 553–556. DOI: 10.1002/jps.2600770620. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOAc
Substance:

guaianolides (RF-00010821-PAR)
Additional substance description:

montacephalin (guaianolide sesquiterpene)
Substance used for equivalence:

Sesquiterpene lactones (RF-00004319-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR, NMR, MS
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.009
Internal remarks:

montacephalin in leaves

Composition #9: TOPCU, G., CORDELL, GA., FARNSWORTH, NR., FONG, HHS. STUDIES ON ZOAPATLE .8. NOVEL CYTO-TOXIC SESQUITERPENE LACTONES FROM MONTANOA-TOMENTOSA SSP MICROCEPHALA . journal of pharmaceutical sciences, 1988, vol. 77, no. 6, p. 553–556. DOI: 10.1002/jps.2600770620. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOAc
Substance:

guaianolides (RF-00010821-PAR)
Additional substance description:

tomencephalin (guaianolide sesquiterpene)
Substance used for equivalence:

Sesquiterpene lactones (RF-00004319-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR, NMR, MS
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0022
Internal remarks:

tomencephalin in leaves

Composition #10: QUIJANO, L., GOMEZ, F., SIERRA, E., RIOS, T. ACYCLIC DITERPENES AND SESQUITERPENE LACTONES FROM MONTANOA-TOMENTOSA SUBSP TOMENTOSA . phytochemistry, 1991, vol. 30, no. 6, p. 1947–1950. DOI: 10.1016/0031-9422(91)85045-2. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petrol, petrol-EtOAc (8:2), EtOAc
Substance:

Diterpenes Diterpenes (RF-00004378-PAR)
Additional substance description:

zoapatol A, zoapatol B
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, CC, IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

zoapatol A, zoapatol B in leaves

Composition #11: QUIJANO, L., GOMEZ, F., SIERRA, E., RIOS, T. ACYCLIC DITERPENES AND SESQUITERPENE LACTONES FROM MONTANOA-TOMENTOSA SUBSP TOMENTOSA . phytochemistry, 1991, vol. 30, no. 6, p. 1947–1950. DOI: 10.1016/0031-9422(91)85045-2. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petrol, petrol-EtOAc (8:2), EtOAc
Substance:

guaianolides (RF-00010821-PAR)
Additional substance description:

zoapatanolide F
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, CC, IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

zoapatanolide F in leaves

Composition #12: LIDIAPEREZ, A., CABALLERO, MBA., ORTEGA, A., GAVINO, R., DEVIVAR, AR. NEW SESQUITERPENE LACTONES FROM MONTANOA-TOMENTOSA SUBSP XANTHIIFOLIA. planta medica, 1994, vol. 60, no. 3, p. 263–266. DOI: 10.1055/s-2006-959472. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, CI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sesquiterpene lactones in aerial part

Composition #13: Enriquez, RG., Miranda, E., Ortiz, B., Leon, I., Magos, G., Pena, A., Reynolds, WF., Gnecco, D. The unambiguous detection of kaurenic derivatives in aqueous infusions of Montanoa tomentosa by GC-MS and 2D-NMR spectroscopy: An answer to contradictory reports . planta medica, 1996, vol. 62, no. 6, p. 569–571. DOI: 10.1055/s-2006-957976. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CH2CI2, Et20, and EtOAc,
Substance:

Diterpenes Diterpenes (RF-00004378-PAR)
Additional substance description:

kauradienoic acid, monoginoic acid
Analytical method - additional description:

HPLC, GC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

kauradienoic acid, monoginoic acid in leaves

Composition #14: Enriquez, RG., Miranda, E., Ortiz, B., Leon, I., Magos, G., Pena, A., Reynolds, WF., Gnecco, D. The unambiguous detection of kaurenic derivatives in aqueous infusions of Montanoa tomentosa by GC-MS and 2D-NMR spectroscopy: An answer to contradictory reports . planta medica, 1996, vol. 62, no. 6, p. 569–571. DOI: 10.1055/s-2006-957976. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CH2CI2, Et20, and EtOAc,
Substance:

kaurenoic acids (RF-00003462-PAR)
Analytical method - additional description:

HPLC, GC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

kaurenoic acid

Endpoint study #1: Carro-Juarez, M., Cervantes, E., Cervantes-Mendez, M., Rodriguez-Manzo, G. Aphrodisiac properties of Montanoa tomentosa aqueous crude extract in male rats . pharmacology biochemistry and behavior, 2004, vol. 78, no. 1, p. 129–134. DOI: 10.1016/j.pbb.2004.03.001. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

distilled water; leaves and flowers
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

1.0
Unit of exposure duration:

single (food/feed) (G203A)
Number of organisms dosed:

27
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight (G225A)
Effect concentration:

38
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

Urogenital (TT006A)
Effect description:

reductions in the number of intromissions, the ejaculation latency and the postejaculatory interval; important facilitation of mounting behavior
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

male sexual behavior expression after single dose

Endpoint study #2: HAHN, DW., ERICSON, EW., LAI, MT., PROBST, A. ANTI-FERTILITY ACTIVITY OF MONTANOA-TOMENTOSA (ZOAPATLE). contraception, 1981, vol. 23, no. 2, p. 133–140. DOI: 10.1016/0010-7824(81)90099-8. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Guinea pig (as animal) (A0CTN)
Strain of test organism:

Other (CHD049ST)
Sex:

Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

1.0
Unit of exposure duration:

single (food/feed) (G203A)
Number of organisms dosed:

10
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

250
Critical effect:

DEVELOPMENTAL (TOX07A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

antifertility activity
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

antifertility activity of crude extract in quinea pigs after single dose

Endpoint study #3: HAHN, DW., ERICSON, EW., LAI, MT., PROBST, A. ANTI-FERTILITY ACTIVITY OF MONTANOA-TOMENTOSA (ZOAPATLE). contraception, 1981, vol. 23, no. 2, p. 133–140. DOI: 10.1016/0010-7824(81)90099-8. [DOI link]

Study relevance:

Human health
Substance:

zoapatanol (RF-00003642-PAR)
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Guinea pig (as animal) (A0CTN)
Strain of test organism:

Other (CHD049ST)
Sex:

Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

1.0
Unit of exposure duration:

single (food/feed) (G203A)
Number of organisms dosed:

12
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

100
Critical effect:

DEVELOPMENTAL (TOX07A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

antifertility activity
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

antifertility activity of zoapatanol in quinea pigs after single dose

Endpoint study #4: HAHN, DW., ERICSON, EW., LAI, MT., PROBST, A. ANTI-FERTILITY ACTIVITY OF MONTANOA-TOMENTOSA (ZOAPATLE). contraception, 1981, vol. 23, no. 2, p. 133–140. DOI: 10.1016/0010-7824(81)90099-8. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

6.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

19
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

100
Critical effect:

DEVELOPMENTAL (TOX07A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

antifertility activity
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

antifertility activity of crude extract in rats

Endpoint study #5: HAHN, DW., ERICSON, EW., LAI, MT., PROBST, A. ANTI-FERTILITY ACTIVITY OF MONTANOA-TOMENTOSA (ZOAPATLE). contraception, 1981, vol. 23, no. 2, p. 133–140. DOI: 10.1016/0010-7824(81)90099-8. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

CD-1 (CHD003ST)
Sex:

Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

6.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

46
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

250
Critical effect:

DEVELOPMENTAL (TOX07A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

antifertility activity
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

antifertility activity of crude extract in mice