EFSA Compendium of Botanicals

Draft - work in progress

Mentha canadensis L. // Mentha haplocalyx Briq.

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 765
Number of processed references:: 5

Compositions

#1: Menthol in dried aerial parts #2: p-Menthone in dried aerial parts #3: Carvone in dried aerial parts #4: p-coumaric acid #5: Aloe-Emodin isolated from M. hoplocalyx #6: chrysophanol isolated from M. hoplocalyx #7: Emodin isolated from M. hoplocalyx #8: Physcione isolated from M. hoplocalyx #9: menthone #10: myrcene #11: 3,4-dihydro-3,6,7-trihydroxy-2(1H)-quinolinone - quinoline alkaloid #12: coumaric acid #13: esculetin #14: syringaresinol

Endpoint Studies

Genotoxicity

Composition #1: Zhao, Chenxi., Zeng, Yingxu., Wan, Mingzhu., Li, Rongxi., Liang, Yizeng., Li, Chengyong., Zeng, Zhongda., Chau, Foo-Tim. Comparative analysis of essential oils from eight herbal medicines with pungent flavor and cool nature by GC-MS and chemometric resolution methods. journal of separation science, 2009, vol. 32, no. 4, p. 660–670. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

Menthol (RF-00008951-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent/sample (G087A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

11.33
Internal remarks:

Menthol in dried aerial parts

Composition #2: Zhao, Chenxi., Zeng, Yingxu., Wan, Mingzhu., Li, Rongxi., Liang, Yizeng., Li, Chengyong., Zeng, Zhongda., Chau, Foo-Tim. Comparative analysis of essential oils from eight herbal medicines with pungent flavor and cool nature by GC-MS and chemometric resolution methods. journal of separation science, 2009, vol. 32, no. 4, p. 660–670. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

d,l-Isomenthone (RF-00010214-PAR)
Additional substance description:

p-Menthone
Analytical method code:

GC-MS (F046A)
Result unit:

Percent/sample (G087A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.4
Internal remarks:

p-Menthone in dried aerial parts

Composition #3: Zhao, Chenxi., Zeng, Yingxu., Wan, Mingzhu., Li, Rongxi., Liang, Yizeng., Li, Chengyong., Zeng, Zhongda., Chau, Foo-Tim. Comparative analysis of essential oils from eight herbal medicines with pungent flavor and cool nature by GC-MS and chemometric resolution methods. journal of separation science, 2009, vol. 32, no. 4, p. 660–670. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

Carvone (RF-0538-001-PPP)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent/sample (G087A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

36.9
Internal remarks:

Carvone in dried aerial parts

Composition #4: Chen Xiangyang., Liu Bin., Zhang Shujing., Ge Dongyu., Xuan Zinan., Chen Xiaoming., Zhang Junjie., Wu Ying., Wang Qian. The Phenolic Fraction of Mentha haplocalyx and Its Constituent Linarin Ameliorate Inflammatory Response through Inactivation of NF-κB and MAPKs in Lipopolysaccharide-Induced RAW264.7 Cells. molecules (basel, switzerland), 2017, p. 22(5). .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

30% EtOH
Substance:

p-coumaric acid (RF-00010717-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

p-coumaric acid

Composition #5: Liu Ying., Zhang Yuan-hu., Shi Ren-bing. Studies on the chemical constituents in herb of Mentha haplocalyx. zhongguo zhongyao zazhi, 2005, vol. 30, no. 14, p. 1086–1088. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

Aloe-emodin (RF-00003670-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

column chromatography and the structures were then elucidated by spectral analysis
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Aloe-Emodin isolated from M. hoplocalyx

Composition #6: Liu Ying., Zhang Yuan-hu., Shi Ren-bing. Studies on the chemical constituents in herb of Mentha haplocalyx. zhongguo zhongyao zazhi, 2005, vol. 30, no. 14, p. 1086–1088. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

chrysophanol (RF-00003737-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

column chromatography and the structures were then elucidated by spectral analysis
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

chrysophanol isolated from M. hoplocalyx

Composition #7: Liu Ying., Zhang Yuan-hu., Shi Ren-bing. Studies on the chemical constituents in herb of Mentha haplocalyx. zhongguo zhongyao zazhi, 2005, vol. 30, no. 14, p. 1086–1088. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

Emodin (RF-00003798-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

column chromatography and the structures were then elucidated by spectral analysis
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Emodin isolated from M. hoplocalyx

Composition #8: Liu Ying., Zhang Yuan-hu., Shi Ren-bing. Studies on the chemical constituents in herb of Mentha haplocalyx. zhongguo zhongyao zazhi, 2005, vol. 30, no. 14, p. 1086–1088. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

physcion (RF-00003993-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

column chromatography and the structures were then elucidated by spectral analysis
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Physcione isolated from M. hoplocalyx

Composition #9: Zheljazkov, Valtcho D., Astatkie, Tess. Effect of Distillation Time on Mentha canadensis Essential Oil Yield and Composition . hortscience, 2012, vol. 47, no. 5, p. 643–647. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

distillation
Substance:

menthone (RF-00011280-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.32-6.3
Internal remarks:

menthone

Composition #10: Zheljazkov, Valtcho D., Astatkie, Tess. Effect of Distillation Time on Mentha canadensis Essential Oil Yield and Composition . hortscience, 2012, vol. 47, no. 5, p. 643–647. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

distillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.23-0.45
Internal remarks:

myrcene

Composition #11: Li, Mingliang., Xu, Lingyu., Li, Zhenlin., Qian, Shihui., Qin, Minjian. Chemical constituents from Mentha canadensis. biochemical systematics and ecology, 2013, vol. 49, p. 144–147. DOI: 10.1016/j.bse.2013.03.021. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dried aerial parts of M. canadensis (14 kg) were refluxed with 80% EtOH (112 L, 2 h) once, and 40% EtOH (2 _ 112 L, 2 h each) two times
Substance:

Quinoline alkaloids (RF-00004326-PAR)
Additional substance description:

3,4-dihydro-3,6,7-trihydroxy-2(1H)-quinolinone
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Analytical method - additional description:

HR-ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

3,4-dihydro-3,6,7-trihydroxy-2(1H)-quinolinone - quinoline alkaloid

Composition #12: Li, Mingliang., Xu, Lingyu., Li, Zhenlin., Qian, Shihui., Qin, Minjian. Chemical constituents from Mentha canadensis. biochemical systematics and ecology, 2013, vol. 49, p. 144–147. DOI: 10.1016/j.bse.2013.03.021. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dried aerial parts of M. canadensis (14 kg) were refluxed with 80% EtOH (112 L, 2 h) once, and 40% EtOH (2 _ 112 L, 2 h each) two times
Substance:

p-coumaric acid (RF-00010717-PAR)
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Analytical method - additional description:

HR-ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

coumaric acid

Composition #13: Li, Mingliang., Xu, Lingyu., Li, Zhenlin., Qian, Shihui., Qin, Minjian. Chemical constituents from Mentha canadensis. biochemical systematics and ecology, 2013, vol. 49, p. 144–147. DOI: 10.1016/j.bse.2013.03.021. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dried aerial parts of M. canadensis (14 kg) were refluxed with 80% EtOH (112 L, 2 h) once, and 40% EtOH (2 _ 112 L, 2 h each) two times
Substance:

Esculetin (RF-00003667-PAR)
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Analytical method - additional description:

HR-ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

esculetin

Composition #14: Li, Mingliang., Xu, Lingyu., Li, Zhenlin., Qian, Shihui., Qin, Minjian. Chemical constituents from Mentha canadensis. biochemical systematics and ecology, 2013, vol. 49, p. 144–147. DOI: 10.1016/j.bse.2013.03.021. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dried aerial parts of M. canadensis (14 kg) were refluxed with 80% EtOH (112 L, 2 h) once, and 40% EtOH (2 _ 112 L, 2 h each) two times
Substance:

syringaresinol (RF-00011386-PAR)
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Analytical method - additional description:

HR-ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

syringaresinol