EFSA Compendium of Botanicals

Draft - work in progress

Menispermum dauricum DC.

Family:: Menispermaceae
Approval state:: Approved
Number of articles retrieved:: 366
Number of processed references:: 9

Compositions

#1: Dauricinolin, nor-thalifoline, sinomenine, tetrandrine, dicentrine, corydine, #2: dauriporphine, menisporphine, 6-O-demethylmenisporphine, dauriporphinoline, menisperine, magnoflorine, acutumine, acutumidine, N-demethyl-N-formyldehydronuciferine, epiberberine in rhizome #3: norsinoacutin in roots #4: dauricinoline, laurifloline, 6-O-methyl-laudanosoline −13-Oglucopyranoside #5: sinomenine in roots #6: magnoflorine in roots #7: N-norsinoacutin-β-D-glucopyranoside in roots #8: Daurioxoisorphines B and C and Liriodenine D #9: dauricine in roots #10: dauricicoline, daurinoline and daurisoline in roots #11: acutuminine, dauricumidine and dauricumine in rhizome #12: N-trans feruloyltyramine in rhizome #13: physcion in rhizome #14: tetrandrine in rhizomes #15: sinomenine in rhizomes #16: Acutumidine in rhizomes #17: Acutumine in rhizomes #18: Magnoflorine in rhizomes #19: Menisperine in rhizomes #20: Dauricine in rhizomes #21: Menisporphine in rhizomes #22: N-demethyl-N-formyldehydronuciferine in rhizomes #23: 6-O-demethylmenisporphine in rhizomes #24: Dauriporphine in rhizomes #25: dauriporphinoline in rhizomes #26: dauricine in rhizomes #27: daurisoline in rhizomes #28: dauricicoline in rhizomes #29: bianfugecine in rhizomes #30: N-desmethyldauricine in rhizomes #31: dauricoside in rhizomes #32: stepholidine in rhizomes #33: acutumine in rhizomes #34: acutumidine in rhizomes

Endpoint Studies

Genotoxicity

Composition #1: Cong, Guo-yan., Yan, Yong-bo., Gao, Yu., Xu, Kai., Wang, Qi. Study on chemical constituents of Menispermum dauricum DC. xiandai shengwuyixue jinzhan, 2013, vol. 13, no. 18, p. 3567–3569. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Dauricinolin, nor-thalifoline, sinomenine, tetrandrine, dicentrine, corydine,
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Dauricinolin, nor-thalifoline, sinomenine, tetrandrine, dicentrine, corydine,

Composition #2: Li, Shan-shan., Song, Xiao., Chai, Xin., Wang, Yue-fei. Chemical constituents in rhizome of menispermum dauricum DC.. tianran chanwu yanjiu yu kaifa, 2013, vol. 25, no. 1, p. 60–63. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

dauriporphine, menisporphine, 6-O-demethylmenisporphine, dauriporphinoline, menisperine, magnoflorine, acutumine, acutumidine, N-demethyl-N-formyldehydronuciferine, epiberberine
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

dauriporphine, menisporphine, 6-O-demethylmenisporphine, dauriporphinoline, menisperine, magnoflorine, acutumine, acutumidine, N-demethyl-N-formyldehydronuciferine, epiberberine in rhizome

Composition #3: Sun, Dan., Zhou, Mengge., Ying, Xuhui., Cheng, Binfeng., Han, Yanqi., Nie, Yan., Hou, Yuanyuan., Bai, Gang. Identification of nuclear factor-κB inhibitors in the folk herb Rhizoma Menispermi via bioactivity-based ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry analysis. bmc complementary and alternative medicine, 2014, vol. 14, p. 1–18. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Norsinoacutine (RF-00011152-PAR)
Analytical method code:

LC-MS (F026A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

norsinoacutin in roots

Composition #4: Sun, Dan., Zhou, Mengge., Ying, Xuhui., Cheng, Binfeng., Han, Yanqi., Nie, Yan., Hou, Yuanyuan., Bai, Gang. Identification of nuclear factor-κB inhibitors in the folk herb Rhizoma Menispermi via bioactivity-based ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry analysis. bmc complementary and alternative medicine, 2014, vol. 14, p. 1–18. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

dauricinoline, laurifloline, 6-O-methyl-laudanosoline −13-Oglucopyranoside
Analytical method code:

LC-MS (F026A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

dauricinoline, laurifloline, 6-O-methyl-laudanosoline −13-Oglucopyranoside

Composition #5: Sun, Dan., Zhou, Mengge., Ying, Xuhui., Cheng, Binfeng., Han, Yanqi., Nie, Yan., Hou, Yuanyuan., Bai, Gang. Identification of nuclear factor-κB inhibitors in the folk herb Rhizoma Menispermi via bioactivity-based ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry analysis. bmc complementary and alternative medicine, 2014, vol. 14, p. 1–18. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

sinomenine (RF-00003579-PAR)
Analytical method code:

LC-MS (F026A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sinomenine in roots

Composition #6: Sun, Dan., Zhou, Mengge., Ying, Xuhui., Cheng, Binfeng., Han, Yanqi., Nie, Yan., Hou, Yuanyuan., Bai, Gang. Identification of nuclear factor-κB inhibitors in the folk herb Rhizoma Menispermi via bioactivity-based ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry analysis. bmc complementary and alternative medicine, 2014, vol. 14, p. 1–18. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

magnoflorine (RF-00003919-PAR)
Analytical method code:

LC-MS (F026A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

magnoflorine in roots

Composition #7: Sun, Dan., Zhou, Mengge., Ying, Xuhui., Cheng, Binfeng., Han, Yanqi., Nie, Yan., Hou, Yuanyuan., Bai, Gang. Identification of nuclear factor-κB inhibitors in the folk herb Rhizoma Menispermi via bioactivity-based ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry analysis. bmc complementary and alternative medicine, 2014, vol. 14, p. 1–18. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Norsinoacutine (RF-00011152-PAR)
Additional substance description:

N-norsinoacutin-β-D-glucopyranoside
Analytical method code:

LC-MS (F026A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

N-norsinoacutin-β-D-glucopyranoside in roots

Composition #8: Tang, Huang., Wang, Xiao-Dong., Wei, Yong-Biao., Huang, Shi-Liang., Huang, Zhi-Shu., Tan, Jia-Heng., An, Lin-Kun., Wu, Jian-Yong., Chan, Albert Sun-Chi., Gu, Lian-Quan. Oxoisoaporphine alkaloid derivatives: Synthesis, DNA binding affinity and cytotoxicity . european journal of medicinal chemistry, 2008, vol. 43, no. 5, p. 973–980. DOI: 10.1016/j.ejmech.2007.07.004. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Daurioxoisorphines B and C and Liriodenine D
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Daurioxoisorphines B and C and Liriodenine D

Composition #9: Luo, Houding., Peng, Ming., Ye, Haoyu., Chen, Lijuan., Peng, Aihua., Tang, Minghai., Zhang, Fan., Shi, Jie. Predictable and linear scale-up of four phenolic alkaloids separation from the roots of Menispermum dauricum using high-performance counter-current chromatography . journal of chromatography b-analytical technologies in the biomedical and life sciences, 2010, vol. 878, no. 22, p. 1929–1933. DOI: 10.1016/j.jchromb.2010.05.002. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

light petroleum (b.p. 60–90 .C)–ethyl acetate–ethanol–water
Substance:

dauricine (RF-00004253-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

High Performance Countercurrent Chromatography
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

98.55
Internal remarks:

dauricine in roots

Composition #10: Luo, Houding., Peng, Ming., Ye, Haoyu., Chen, Lijuan., Peng, Aihua., Tang, Minghai., Zhang, Fan., Shi, Jie. Predictable and linear scale-up of four phenolic alkaloids separation from the roots of Menispermum dauricum using high-performance counter-current chromatography . journal of chromatography b-analytical technologies in the biomedical and life sciences, 2010, vol. 878, no. 22, p. 1929–1933. DOI: 10.1016/j.jchromb.2010.05.002. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

light petroleum (b.p. 60–90 .C)–ethyl acetate–ethanol–water
Substance:

Bisbenzylisoquinoline alkaloids (RF-00010792-PAR)
Additional substance description:

dauricicoline, daurinoline, daurisoline
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

High Performance Countercurrent Chromatography
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.35
Internal remarks:

dauricicoline, daurinoline and daurisoline in roots

Composition #11: Chen Jian-Yong., Xie Yu-Feng., Zhou Tian-Xi., Qin Guo-Wei. Chemical constituents of Menispermum dauricum. chinese journal of natural medicines, 2012, vol. 10, no. 4, p. 292–294. DOI: 10.3724/SP.J.1009.2012.00292. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

boiling ethanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

acutuminine, dauricumidine and dauricumine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

UV, IR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

acutuminine, dauricumidine and dauricumine in rhizome

Composition #12: Chen Jian-Yong., Xie Yu-Feng., Zhou Tian-Xi., Qin Guo-Wei. Chemical constituents of Menispermum dauricum. chinese journal of natural medicines, 2012, vol. 10, no. 4, p. 292–294. DOI: 10.3724/SP.J.1009.2012.00292. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

boiling ethanol
Substance:

Moupinamide (RF-00011093-PAR)
Additional substance description:

N-trans feruloyltyramine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

MS, IR, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

N-trans feruloyltyramine in rhizome

Composition #13: Chen Jian-Yong., Xie Yu-Feng., Zhou Tian-Xi., Qin Guo-Wei. Chemical constituents of Menispermum dauricum. chinese journal of natural medicines, 2012, vol. 10, no. 4, p. 292–294. DOI: 10.3724/SP.J.1009.2012.00292. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

boiling ethanol
Substance:

physcion (RF-00003993-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

UV, IR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

physcion in rhizome

Composition #14: Chen, Qinhua., Zhang, Juan., Zhang, Wenpeng., Chen, Zilin. Analysis of active alkaloids in the Menispermaceae family by nonaqueous capillary electrophoresis-ion trap mass spectrometry . journal of separation science, 2013, vol. 36, no. 2, p. 341–349. DOI: 10.1002/jssc.201200678. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol and ACN
Substance:

tetrandrine (RF-00004075-PAR)
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Analytical method - additional description:

Capillary electrophoresis–mass spectrometry
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.84
Internal remarks:

tetrandrine in rhizomes

Composition #15: Chen, Qinhua., Zhang, Juan., Zhang, Wenpeng., Chen, Zilin. Analysis of active alkaloids in the Menispermaceae family by nonaqueous capillary electrophoresis-ion trap mass spectrometry . journal of separation science, 2013, vol. 36, no. 2, p. 341–349. DOI: 10.1002/jssc.201200678. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol and ACN
Substance:

sinomenine (RF-00003579-PAR)
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Analytical method - additional description:

Capillary electrophoresis–mass spectrometry
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

9.30
Internal remarks:

sinomenine in rhizomes

Composition #16: Liu, Yanan., Song, Xiao., Yan, Ruiqing., Li, Tianxiang., Chai, Xin., Qi, Aidi., Wang, Yuefei., Jiang, Zhenzuo. Development and validation of a UPLC-DAD-MS method for characterization and quantification of alkaloids in Menispermi Rhizoma and its preparations . journal of food and drug analysis, 2013, vol. 21, no. 2, p. 206–218. DOI: 10.1016/j.jfda.2013.05.012. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Acutumine (RF-00011032-PAR)
Additional substance description:

Acutumidine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.788 - 1.610
Internal remarks:

Acutumidine in rhizomes

Composition #17: Liu, Yanan., Song, Xiao., Yan, Ruiqing., Li, Tianxiang., Chai, Xin., Qi, Aidi., Wang, Yuefei., Jiang, Zhenzuo. Development and validation of a UPLC-DAD-MS method for characterization and quantification of alkaloids in Menispermi Rhizoma and its preparations . journal of food and drug analysis, 2013, vol. 21, no. 2, p. 206–218. DOI: 10.1016/j.jfda.2013.05.012. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Acutumine (RF-00011032-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.172 - 0.804
Internal remarks:

Acutumine in rhizomes

Composition #18: Liu, Yanan., Song, Xiao., Yan, Ruiqing., Li, Tianxiang., Chai, Xin., Qi, Aidi., Wang, Yuefei., Jiang, Zhenzuo. Development and validation of a UPLC-DAD-MS method for characterization and quantification of alkaloids in Menispermi Rhizoma and its preparations . journal of food and drug analysis, 2013, vol. 21, no. 2, p. 206–218. DOI: 10.1016/j.jfda.2013.05.012. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

magnoflorine (RF-00003919-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8.12 - 17.42
Internal remarks:

Magnoflorine in rhizomes

Composition #19: Liu, Yanan., Song, Xiao., Yan, Ruiqing., Li, Tianxiang., Chai, Xin., Qi, Aidi., Wang, Yuefei., Jiang, Zhenzuo. Development and validation of a UPLC-DAD-MS method for characterization and quantification of alkaloids in Menispermi Rhizoma and its preparations . journal of food and drug analysis, 2013, vol. 21, no. 2, p. 206–218. DOI: 10.1016/j.jfda.2013.05.012. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Aporphine alkaloids (RF-00010806-PAR)
Additional substance description:

Menisperine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.74 - 11.03
Internal remarks:

Menisperine in rhizomes

Composition #20: Liu, Yanan., Song, Xiao., Yan, Ruiqing., Li, Tianxiang., Chai, Xin., Qi, Aidi., Wang, Yuefei., Jiang, Zhenzuo. Development and validation of a UPLC-DAD-MS method for characterization and quantification of alkaloids in Menispermi Rhizoma and its preparations . journal of food and drug analysis, 2013, vol. 21, no. 2, p. 206–218. DOI: 10.1016/j.jfda.2013.05.012. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

dauricine (RF-00004253-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.39 - 8.96
Internal remarks:

Dauricine in rhizomes

Composition #21: Liu, Yanan., Song, Xiao., Yan, Ruiqing., Li, Tianxiang., Chai, Xin., Qi, Aidi., Wang, Yuefei., Jiang, Zhenzuo. Development and validation of a UPLC-DAD-MS method for characterization and quantification of alkaloids in Menispermi Rhizoma and its preparations . journal of food and drug analysis, 2013, vol. 21, no. 2, p. 206–218. DOI: 10.1016/j.jfda.2013.05.012. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Menisporphine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.011 - 0.130
Internal remarks:

Menisporphine in rhizomes

Composition #22: Liu, Yanan., Song, Xiao., Yan, Ruiqing., Li, Tianxiang., Chai, Xin., Qi, Aidi., Wang, Yuefei., Jiang, Zhenzuo. Development and validation of a UPLC-DAD-MS method for characterization and quantification of alkaloids in Menispermi Rhizoma and its preparations . journal of food and drug analysis, 2013, vol. 21, no. 2, p. 206–218. DOI: 10.1016/j.jfda.2013.05.012. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Nuciferine (RF-00013328-PAR)
Additional substance description:

N-demethyl-N-formyldehydronuciferine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.012 - 0.120
Internal remarks:

N-demethyl-N-formyldehydronuciferine in rhizomes

Composition #23: Liu, Yanan., Song, Xiao., Yan, Ruiqing., Li, Tianxiang., Chai, Xin., Qi, Aidi., Wang, Yuefei., Jiang, Zhenzuo. Development and validation of a UPLC-DAD-MS method for characterization and quantification of alkaloids in Menispermi Rhizoma and its preparations . journal of food and drug analysis, 2013, vol. 21, no. 2, p. 206–218. DOI: 10.1016/j.jfda.2013.05.012. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

6-O-demethylmenisporphine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.013 - 0.120
Internal remarks:

6-O-demethylmenisporphine in rhizomes

Composition #24: Liu, Yanan., Song, Xiao., Yan, Ruiqing., Li, Tianxiang., Chai, Xin., Qi, Aidi., Wang, Yuefei., Jiang, Zhenzuo. Development and validation of a UPLC-DAD-MS method for characterization and quantification of alkaloids in Menispermi Rhizoma and its preparations . journal of food and drug analysis, 2013, vol. 21, no. 2, p. 206–218. DOI: 10.1016/j.jfda.2013.05.012. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Aporphine alkaloids (RF-00010806-PAR)
Additional substance description:

Dauriporphine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.008 - 0.083
Internal remarks:

Dauriporphine in rhizomes

Composition #25: Wei, Jinxia., Fang, Linlin., Liang, Xinlei., Su, Dan., Guo, Xingjie. A sensitive and selective UPLC-MS/MS method for simultaneous determination of 10 alkaloids from Rhizoma Menispermi in rat plasma and its application to a pharmacokinetic study . talanta, 2015, vol. 144, p. 662–670. DOI: 10.1016/j.talanta.2015.07.023. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol-water (75:25)
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

dauriporphinoline
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.17
Internal remarks:

dauriporphinoline in rhizomes

Composition #26: Wei, Jinxia., Fang, Linlin., Liang, Xinlei., Su, Dan., Guo, Xingjie. A sensitive and selective UPLC-MS/MS method for simultaneous determination of 10 alkaloids from Rhizoma Menispermi in rat plasma and its application to a pharmacokinetic study . talanta, 2015, vol. 144, p. 662–670. DOI: 10.1016/j.talanta.2015.07.023. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol-water (75:25)
Substance:

dauricine (RF-00004253-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

21.38
Internal remarks:

dauricine in rhizomes

Composition #27: Wei, Jinxia., Fang, Linlin., Liang, Xinlei., Su, Dan., Guo, Xingjie. A sensitive and selective UPLC-MS/MS method for simultaneous determination of 10 alkaloids from Rhizoma Menispermi in rat plasma and its application to a pharmacokinetic study . talanta, 2015, vol. 144, p. 662–670. DOI: 10.1016/j.talanta.2015.07.023. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol-water (75:25)
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

daurisoline
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

34.55
Internal remarks:

daurisoline in rhizomes

Composition #28: Wei, Jinxia., Fang, Linlin., Liang, Xinlei., Su, Dan., Guo, Xingjie. A sensitive and selective UPLC-MS/MS method for simultaneous determination of 10 alkaloids from Rhizoma Menispermi in rat plasma and its application to a pharmacokinetic study . talanta, 2015, vol. 144, p. 662–670. DOI: 10.1016/j.talanta.2015.07.023. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol-water (75:25)
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

dauricicoline
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.55
Internal remarks:

dauricicoline in rhizomes

Composition #29: Wei, Jinxia., Fang, Linlin., Liang, Xinlei., Su, Dan., Guo, Xingjie. A sensitive and selective UPLC-MS/MS method for simultaneous determination of 10 alkaloids from Rhizoma Menispermi in rat plasma and its application to a pharmacokinetic study . talanta, 2015, vol. 144, p. 662–670. DOI: 10.1016/j.talanta.2015.07.023. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol-water (75:25)
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

bianfugecine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.002
Internal remarks:

bianfugecine in rhizomes

Composition #30: Wei, Jinxia., Fang, Linlin., Liang, Xinlei., Su, Dan., Guo, Xingjie. A sensitive and selective UPLC-MS/MS method for simultaneous determination of 10 alkaloids from Rhizoma Menispermi in rat plasma and its application to a pharmacokinetic study . talanta, 2015, vol. 144, p. 662–670. DOI: 10.1016/j.talanta.2015.07.023. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol-water (75:25)
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

N-desmethyldauricine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.65
Internal remarks:

N-desmethyldauricine in rhizomes

Composition #31: Wei, Jinxia., Fang, Linlin., Liang, Xinlei., Su, Dan., Guo, Xingjie. A sensitive and selective UPLC-MS/MS method for simultaneous determination of 10 alkaloids from Rhizoma Menispermi in rat plasma and its application to a pharmacokinetic study . talanta, 2015, vol. 144, p. 662–670. DOI: 10.1016/j.talanta.2015.07.023. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol-water (75:25)
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

dauricoside
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.25
Internal remarks:

dauricoside in rhizomes

Composition #32: Wei, Jinxia., Fang, Linlin., Liang, Xinlei., Su, Dan., Guo, Xingjie. A sensitive and selective UPLC-MS/MS method for simultaneous determination of 10 alkaloids from Rhizoma Menispermi in rat plasma and its application to a pharmacokinetic study . talanta, 2015, vol. 144, p. 662–670. DOI: 10.1016/j.talanta.2015.07.023. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol-water (75:25)
Substance:

Stepholidine (RF-00011141-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.036
Internal remarks:

stepholidine in rhizomes

Composition #33: Wei, Jinxia., Fang, Linlin., Liang, Xinlei., Su, Dan., Guo, Xingjie. A sensitive and selective UPLC-MS/MS method for simultaneous determination of 10 alkaloids from Rhizoma Menispermi in rat plasma and its application to a pharmacokinetic study . talanta, 2015, vol. 144, p. 662–670. DOI: 10.1016/j.talanta.2015.07.023. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol-water (75:25)
Substance:

Acutumine (RF-00011032-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.65
Internal remarks:

acutumine in rhizomes

Composition #34: Wei, Jinxia., Fang, Linlin., Liang, Xinlei., Su, Dan., Guo, Xingjie. A sensitive and selective UPLC-MS/MS method for simultaneous determination of 10 alkaloids from Rhizoma Menispermi in rat plasma and its application to a pharmacokinetic study . talanta, 2015, vol. 144, p. 662–670. DOI: 10.1016/j.talanta.2015.07.023. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol-water (75:25)
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

acutumidine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.90
Internal remarks:

acutumidine in rhizomes