EFSA
ecomole
vscht
  2. Melia azedarach L. // Melia dubia Cav. // Melia toosendan Siebold & Zucc.

Melia azedarach L. // Melia dubia Cav. // Melia toosendan Siebold & Zucc.

Family:
Meliaceae
Approval state:
Approved
Number of articles retrieved:
2906
Number of processed references:
10
Compositions
#1: 5-hydroxymethylfurfural #2: epipinoresinol #3: lignans (clemaphenol A, (±)balanophonin, evofolin B #4: medioresinol #5: p - hydroxybenzaldehyde #6: p - hydroxybenzoic acid #7: limonoids (azedararide and 12a-acetoxy fraxinellone, fraxinellone and fraxinellonone) in root bark #8: Toosendanin #9: limonoids (9a-hydroxy-12a-acetoxyfraxinellone and 7,14-epoxyazedarachin B, 12a-hydroxyfraxinellone, 9a-hydroxyfraxinellone, azedarachin B, and neoazedarachin B) in roots #10: limonoids (Mesendanin K, Mesendanin L, Mesendanin M) in bark #11: limonoids ( 12-ethoxynimbolinins E and F, 1a-benzoyloxy-3a-acetoxyl-7a-hydroxy-12b-ethoxynimbolinin, nimbolinin B, meliatoosenin L, 14,15-deoxy-11- oxohavanensin 3,12-diacetate, 12a-hydroxymeliatoosenin, toosendansin A, and toosendansin C) in fruits
Endpoint Studies
#1: antifertility, anti-implantation and abortive activity in rats #2: mobility troubles in ostriches #3: digestive troubles in ostriches #4: neurological troubles in ostriches #5: neurotoxicity in children #6: gastrotoxicity in children #7: neurotoxicity in dogs
Genotoxicity
Composition #1: Xie, F., Zhang, M., Zhang, C.-F., Wang, Z.-T., Yu, B.-Y. Studies on chemical constituents in fruit of Melia toosendan. chinese pharmaceutical journal, 2008, vol. 43, no. 14, p. 1066–1069. .
Composition #2: Xie, F., Zhang, M., Zhang, C.-F., Wang, Z.-T., Yu, B.-Y. Studies on chemical constituents in fruit of Melia toosendan. chinese pharmaceutical journal, 2008, vol. 43, no. 14, p. 1066–1069. .
Composition #3: Xie, F., Zhang, M., Zhang, C.-F., Wang, Z.-T., Yu, B.-Y. Studies on chemical constituents in fruit of Melia toosendan. chinese pharmaceutical journal, 2008, vol. 43, no. 14, p. 1066–1069. .
Composition #4: Xie, F., Zhang, M., Zhang, C.-F., Wang, Z.-T., Yu, B.-Y. Studies on chemical constituents in fruit of Melia toosendan. chinese pharmaceutical journal, 2008, vol. 43, no. 14, p. 1066–1069. .
Composition #5: Xie, F., Zhang, M., Zhang, C.-F., Wang, Z.-T., Yu, B.-Y. Studies on chemical constituents in fruit of Melia toosendan. chinese pharmaceutical journal, 2008, vol. 43, no. 14, p. 1066–1069. .
Composition #6: Xie, F., Zhang, M., Zhang, C.-F., Wang, Z.-T., Yu, B.-Y. Studies on chemical constituents in fruit of Melia toosendan. chinese pharmaceutical journal, 2008, vol. 43, no. 14, p. 1066–1069. .
Composition #7: Nakatani, M., Huang, RC., Okamura, H., Iwagawa, T., Tadera, K. Degraded limonoids from Melia azedarach. phytochemistry, 1998, vol. 49, no. 6, p. 1773–1776. DOI: 10.1016/S0031-9422(98)00262-3. [DOI link]
Composition #8: Li, MF., Shi, YL. Toosendanin interferes with pore formation of botulinum toxin type A in PC12 cell membrane . acta pharmacologica sinica, 2006, vol. 27, no. 1, p. 66–70. DOI: 10.1111/j.1745-7254.2006.00236.x. [DOI link]
Composition #9: Fukuyama, Yoshiyasu., Nakaoka, Momoko., Yamamoto, Tomoko., Takahashi, Hironobu., Minami, Hiroyuki. Degraded and oxetane-bearing limonoids from the roots of Melia azedarach. chemical & pharmaceutical bulletin, 2006, vol. 54, no. 8, p. 1219–1222. DOI: 10.1248/cpb.54.1219. [DOI link]
Composition #10: Yuan, Chun-Mao., Zhang, Yu., Tang, Gui-Hua., Li, Yan., He, Hong-Ping., Li, Shi-Fei., Hou, Li., Li, Xing-Yao., Di, Ying-Tong., Li, Shun-Lin., Hua, Hui-Ming., Hao, Xiao-Jiang. Cytotoxic Limonoids from Melia azedarach. planta medica, 2013, vol. 79, no. 2, p. 163–168. DOI: 10.1055/s-0032-1328069. [DOI link]
Composition #11: Zhang, Qiong., Zhang, Yong-Gang., Li, Qing-Shan., Min, Zhi-Da. Two New Nimbolinin-Type Limonoids from the Fruits of Melia toosendan. helvetica chimica acta, 2016, vol. 99, no. 6, p. 462–465. DOI: 10.1002/hlca.201500516. [DOI link]
Endpoint study #1: Roop, J.K., Dhaliwal, P.K. Effect of Melia azedarach Linn seed extract on estrous cycle and reproductive performance in female rats. international journal of pharmtech research, 2015, vol. 8, no. 2, p. 273–279. .
Endpoint study #2: Cooper, Ross G. Poisoning in ostriches following ingestion of toxic plants - field observations . tropical animal health and production, 2007, vol. 39, no. 6, p. 439–442. DOI: 10.1007/s11250-007-9044-y. [DOI link]
Endpoint study #3: Cooper, Ross G. Poisoning in ostriches following ingestion of toxic plants - field observations . tropical animal health and production, 2007, vol. 39, no. 6, p. 439–442. DOI: 10.1007/s11250-007-9044-y. [DOI link]
Endpoint study #4: Cooper, Ross G. Poisoning in ostriches following ingestion of toxic plants - field observations . tropical animal health and production, 2007, vol. 39, no. 6, p. 439–442. DOI: 10.1007/s11250-007-9044-y. [DOI link]
Endpoint study #5: Botha, C. J., Penrith, M. -L. Poisonous plants of veterinary and human importance in southern Africa. journal of ethnopharmacology, 2008, vol. 119, no. 3, p. 549–558. DOI: 10.1016/j.jep.2008.07.022. [DOI link]
Endpoint study #6: Botha, C. J., Penrith, M. -L. Poisonous plants of veterinary and human importance in southern Africa. journal of ethnopharmacology, 2008, vol. 119, no. 3, p. 549–558. DOI: 10.1016/j.jep.2008.07.022. [DOI link]
Endpoint study #7: Ferreiro, D., Orozco, J. P., Miron, C., Real, T., Hernandez-Moreno, D., Soler, F., Perez-Lopez, M. Chinaberry Tree (Melia azedarach) Poisoning in Dog: A Case Report. topics in companion animal medicine, 2010, vol. 25, no. 1, p. 64–67. DOI: 10.1053/j.tcam.2009.07.001. [DOI link]