EFSA Compendium of Botanicals

Draft - work in progress

Magnolia denudata Desr.

Family:: Magnoliaceae
Approval state:: Approved
Number of articles retrieved:: 265
Number of processed references:: 11

Compositions

#1: violaxanthin in buds and twigs #2: lutein epoxide in buds and twigs #3: decahydro-α,α,4a-trimethyl-8-methylene-2-naphthalenemethanol #4: eucalyptol (=1,8-cineole) #5: myrcene #6: 1,8-cineole in flowers #7: machilin G in fruits #8: denudatin A, denudatin B, denudadione B, fargesone A in fruits #9: Neolignan: denudatin A in fruit #10: Phenolic derivatives: denudalide and denudaquinol in fruit #11: Epimagnolin A in flower buds #12: fargesin in flower buds #13: magnoline in flower buds #14: eucalyptol (1,8-cineole) in fresh flowers #15: honokiol in twigs #16: magnolol in twigs #17: tyramine in leaves #18: denudatin A, denudatin B,mirandin B, denudatone, futoenone, burchelin, veraguensin in leaves #19: parthenolide in root bark #20: eudesmin in root bark #21: pinoresinol in root bark #22: trans-isomyristicine in root bark #23: sesamin in root bark #24: kobusin in root bark #25: costunolide in root bark

Endpoint Studies

Genotoxicity

Composition #1: Garcia-Plazaola, Jose I., Hormaetxe, Koldobika., Hernandez, Antonio., Olano, Jose M., Becerril, Jose M. The lutein epoxide cycle in vegetative buds of woody plants. functional plant biology, 2004, vol. 31, no. 8, p. 815–823. .

Language:

English (en)
Plant part:

Bud (as part-nature) (A066Z)
Additional extraction description:

unspecified
Substance:

Violaxanthin (RF-00013331-PAR)
Analytical method - additional description:

unspecified
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

violaxanthin in buds and twigs

Composition #2: Garcia-Plazaola, Jose I., Hormaetxe, Koldobika., Hernandez, Antonio., Olano, Jose M., Becerril, Jose M. The lutein epoxide cycle in vegetative buds of woody plants. functional plant biology, 2004, vol. 31, no. 8, p. 815–823. .

Language:

English (en)
Plant part:

Bud (as part-nature) (A066Z)
Additional extraction description:

unspecified
Substance:

Lutein epoxide (RF-00011263-PAR)
Analytical method - additional description:

unspecified
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lutein epoxide in buds and twigs

Composition #3: Zhang, Jian., Sun, Peilong., Xu, Shuangyang., Yang, Kai. Chemical constituents in essential oil from Magnolia denudata Desr.. jingxi huagong, 2006, vol. 23, no. 4), 372-37, p. 396. .

Language:

English (en)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodestilation
Substance:

beta-Eudesmol (RF-00010708-PAR)
Additional substance description:

decahydro-α,α,4a-trimethyl-8-methylene-2-naphthalenemethanol
Analytical method code:

GC*GC/MS (F690A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.8
Internal remarks:

decahydro-α,α,4a-trimethyl-8-methylene-2-naphthalenemethanol

Composition #4: Zhang, Jian., Sun, Peilong., Xu, Shuangyang., Yang, Kai. Chemical constituents in essential oil from Magnolia denudata Desr.. jingxi huagong, 2006, vol. 23, no. 4), 372-37, p. 396. .

Language:

English (en)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodestilation
Substance:

1,8-cineole (RF-00003470-PAR)
Additional substance description:

eucalyptol
Analytical method code:

GC*GC/MS (F690A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

16.52
Internal remarks:

eucalyptol (=1,8-cineole)

Composition #5: Zhang, Jian., Sun, Peilong., Xu, Shuangyang., Yang, Kai. Chemical constituents in essential oil from Magnolia denudata Desr.. jingxi huagong, 2006, vol. 23, no. 4), 372-37, p. 396. .

Language:

English (en)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodestilation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC*GC/MS (F690A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8.49
Internal remarks:

myrcene

Composition #6: Zuma, Hiroshi., Toyota, Masao., Asakawa, Yoshinori., Kawano, Shoichi. Naphthalene- a constituent of Magnolia flowers. phytochemistry (oxford), 1996, vol. 42, no. 4, p. 999–1004. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

diethyl ether
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

NMR
Result unit:

Percent (G138A)
Result expression:

Reconstituted product (B007A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.9-11.2
Internal remarks:

1,8-cineole in flowers

Composition #7: Noshita, Toshiro., Funayama, Shinji., Hirakawa, Tadayoshi., Kidachi, Yumi., Ryoyama, Kazuo. Machilin G and Four Neolignans from Young Fruits of Magnolia denudata Show Various Degrees of Inhibitory Activity on Nitric Oxide (NO) Production . bioscience biotechnology and biochemistry, 2008, vol. 72, no. 10, p. 2775–2778. DOI: 10.1271/bbb.80327. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

N-hexane, chloroform, methanol
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

machilin G
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

machilin G in fruits

Composition #8: Noshita, Toshiro., Funayama, Shinji., Hirakawa, Tadayoshi., Kidachi, Yumi., Ryoyama, Kazuo. Machilin G and Four Neolignans from Young Fruits of Magnolia denudata Show Various Degrees of Inhibitory Activity on Nitric Oxide (NO) Production . bioscience biotechnology and biochemistry, 2008, vol. 72, no. 10, p. 2775–2778. DOI: 10.1271/bbb.80327. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

N-hexane, chloroform, methanol
Substance:

neolignans (RF-00004386-PAR)
Additional substance description:

denudatin A, denudatin B, denudadione B, fargesone A
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

denudatin A, denudatin B, denudadione B, fargesone A in fruits

Composition #9: Noshita, Toshiro., Kiyota, Hiromasa., Kidachi, Yumi., Ryoyama, Kazuo., Funayama, Shinji., Hanada, Ken., Murayama, Tetsuya. New Cytotoxic Phenolic Derivatives from Matured Fruits of Magnolia denudata . bioscience biotechnology and biochemistry, 2009, vol. 73, no. 3, p. 726–728. DOI: 10.1271/bbb.80597. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol and n-hexane CHCl3
Substance:

neolignans (RF-00004386-PAR)
Additional substance description:

denudatin A
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Neolignan: denudatin A in fruit

Composition #10: Noshita, Toshiro., Kiyota, Hiromasa., Kidachi, Yumi., Ryoyama, Kazuo., Funayama, Shinji., Hanada, Ken., Murayama, Tetsuya. New Cytotoxic Phenolic Derivatives from Matured Fruits of Magnolia denudata . bioscience biotechnology and biochemistry, 2009, vol. 73, no. 3, p. 726–728. DOI: 10.1271/bbb.80597. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol and n-hexane CHCl3
Substance:

Phenolic compounds Phenolic compounds (RF-00000010-ORG)
Additional substance description:

denudalide and denudaquinol
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Phenolic derivatives: denudalide and denudaquinol in fruit

Composition #11: Kong, Chang-Suk., Lee, Jung Im., Kim, Jung-Ae., Seo, Youngwan. In Vitro Evaluation on the Antiobesity Effect of Lignans from the Flower Buds of Magnolia denudata . journal of agricultural and food chemistry, 2011, vol. 59, no. 10, p. 5665–5670. DOI: 10.1021/jf200230s. [DOI link]

Language:

English (en)
Plant part:

Bud (as part-nature) (A066Z)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CH2Cl2, MeOH
Substance:

epi-Magnolin A (RF-00011385-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

siica gel column chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Epimagnolin A in flower buds

Composition #12: Kong, Chang-Suk., Lee, Jung Im., Kim, Jung-Ae., Seo, Youngwan. In Vitro Evaluation on the Antiobesity Effect of Lignans from the Flower Buds of Magnolia denudata . journal of agricultural and food chemistry, 2011, vol. 59, no. 10, p. 5665–5670. DOI: 10.1021/jf200230s. [DOI link]

Language:

English (en)
Plant part:

Bud (as part-nature) (A066Z)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CH2Cl2, MeOH
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

fargesin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

siica gel column chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

fargesin in flower buds

Composition #13: Kong, Chang-Suk., Lee, Jung Im., Kim, Jung-Ae., Seo, Youngwan. In Vitro Evaluation on the Antiobesity Effect of Lignans from the Flower Buds of Magnolia denudata . journal of agricultural and food chemistry, 2011, vol. 59, no. 10, p. 5665–5670. DOI: 10.1021/jf200230s. [DOI link]

Language:

English (en)
Plant part:

Bud (as part-nature) (A066Z)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CH2Cl2, MeOH
Substance:

Magnoline (RF-00011167-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

siica gel column chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

magnoline in flower buds

Composition #14: Lei, Gaoming., Zhang, Anyun., Liu, Xuesong., Wang, Longhu. Study on the recovered essential oil obtained from hydrosol of Yulania denudata fresh flowers . journal of essential oil research, 2015, vol. 27, no. 2, p. 153–159. DOI: 10.1080/10412905.2014.982875. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

fresh flowers / distilation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

Distillation-titrimetry (modified Monier-William method) (F682A)
Analytical method - additional description:

Clevenger distilled, decanted
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.5-2.4
Internal remarks:

eucalyptol (1,8-cineole) in fresh flowers

Composition #15: Chung, Ching-Yi., Kuo, Wen-Lung., Hwang, Tsong-Long., Chung, Mei-Ing., Chen, Jih-Jung. Biphenyl-Type Neolignan Derivatives from the Twigs of Magnolia denudata and Their Anti-Inflammatory Activity . chemistry & biodiversity, 2015, vol. 12, no. 8, p. 1263–1270. DOI: 10.1002/cbdv.201400297. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

honokiol (RF-00003871-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

honokiol in twigs

Composition #16: Chung, Ching-Yi., Kuo, Wen-Lung., Hwang, Tsong-Long., Chung, Mei-Ing., Chen, Jih-Jung. Biphenyl-Type Neolignan Derivatives from the Twigs of Magnolia denudata and Their Anti-Inflammatory Activity . chemistry & biodiversity, 2015, vol. 12, no. 8, p. 1263–1270. DOI: 10.1002/cbdv.201400297. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

magnolol (RF-00003920-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

magnolol in twigs

Composition #17: MATSUTANI, H., SHIBA, T. TYRAMINE FROM MAGNOLIA SPECIES. phytochemistry, 1975, vol. 14, no. 4, p. 1132–1133. DOI: 10.1016/0031-9422(75)85208-3. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

boiling
Substance:

Tyramine (RF-00000007-BGA)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR, UV
Result unit:

Milligram/100 gram (G057A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8
Internal remarks:

tyramine in leaves

Composition #18: IIDA, T., ICHINO, K., ITO, K. NEOLIGNANS FROM MAGNOLIA-DENUDATA. phytochemistry, 1982, vol. 21, no. 12, p. 2939–2941. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

neolignans (RF-00004386-PAR)
Additional substance description:

denudatin A, denudatin B,mirandin B, denudatone, futoenone, burchelin, veraguensin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

denudatin A, denudatin B,mirandin B, denudatone, futoenone, burchelin, veraguensin in leaves

Composition #19: FUNAYAMA, S., ADACHI, M., AOYAGI, T., NOZOE, S. CYTOCIDAL PRINCIPLES OF MAGNOLIA-DENUDATA. international journal of pharmacognosy, 1995, vol. 33, no. 1, p. 21–24. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3, CH3OH, H2O
Substance:

parthenolide (RF-00003531-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

parthenolide in root bark

Composition #20: FUNAYAMA, S., ADACHI, M., AOYAGI, T., NOZOE, S. CYTOCIDAL PRINCIPLES OF MAGNOLIA-DENUDATA. international journal of pharmacognosy, 1995, vol. 33, no. 1, p. 21–24. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3, CH3OH, H2O
Substance:

(+)-Epieudesmine (RF-00011057-PAR)
Additional substance description:

eudesmin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

eudesmin in root bark

Composition #21: FUNAYAMA, S., ADACHI, M., AOYAGI, T., NOZOE, S. CYTOCIDAL PRINCIPLES OF MAGNOLIA-DENUDATA. international journal of pharmacognosy, 1995, vol. 33, no. 1, p. 21–24. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3, CH3OH, H2O
Substance:

Pinoresinol (RF-00011088-PAR)
Additional substance description:

eudesmin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

pinoresinol in root bark

Composition #22: FUNAYAMA, S., ADACHI, M., AOYAGI, T., NOZOE, S. CYTOCIDAL PRINCIPLES OF MAGNOLIA-DENUDATA. international journal of pharmacognosy, 1995, vol. 33, no. 1, p. 21–24. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3, CH3OH, H2O
Substance:

phenylpropanoids (RF-00004367-PAR)
Additional substance description:

trans-Isomyristicin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

trans-isomyristicine in root bark

Composition #23: FUNAYAMA, S., ADACHI, M., AOYAGI, T., NOZOE, S. CYTOCIDAL PRINCIPLES OF MAGNOLIA-DENUDATA. international journal of pharmacognosy, 1995, vol. 33, no. 1, p. 21–24. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3, CH3OH, H2O
Substance:

asarinin (RF-00004158-PAR)
Additional substance description:

syn for sesamin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sesamin in root bark

Composition #24: FUNAYAMA, S., ADACHI, M., AOYAGI, T., NOZOE, S. CYTOCIDAL PRINCIPLES OF MAGNOLIA-DENUDATA. international journal of pharmacognosy, 1995, vol. 33, no. 1, p. 21–24. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3, CH3OH, H2O
Substance:

Kobusin (RF-00013327-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

kobusin in root bark

Composition #25: FUNAYAMA, S., ADACHI, M., AOYAGI, T., NOZOE, S. CYTOCIDAL PRINCIPLES OF MAGNOLIA-DENUDATA. international journal of pharmacognosy, 1995, vol. 33, no. 1, p. 21–24. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3, CH3OH, H2O
Substance:

costunolide (RF-00003753-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

costunolide in root bark