Draft - work in progress
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- Lycopus europaeus L. // Lycopus menthifolius Mabille // Lycopus mollis A.Kern.
Lycopus europaeus L. // Lycopus menthifolius Mabille // Lycopus mollis A.Kern.
- Family:
- Lamiaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 256
- Number of processed references:
- 4
Composition #1: Sharipov, Sh. N., Goryaev, M. I., Khazanovich, R. L., Pulatova, T. P., Sharipova, F. S. Essential oil from Lycopus europaeus. khimiya prirodnykh soedinenii, 1969, vol. 5, no. 4, p. 316. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Additional extraction description:
Epigeal parts during flowering phase. Reference to previous study, details of extraction not reported.
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Substance:
coumarins (RF-00004351-PAR)
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Additional substance description:
"coumarin substances"
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Analytical method code:
Phytochemical screening (F604A)
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Result unit:
Percent (G138A)
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Result expression:
Dry matter (B002A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.12
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Internal remarks:
Coumarin substances in epigeal parts
Composition #2: Swiatek, L., Grabias, B., Rozga, M. Phenolic acids and coumarins in Lithospermum arvense L. and Lycopus europaeus L. herba polonica, 1987, vol. 33, no. 2, p. 87–97. .
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Plant part:
Unspecified (A07XD)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
unspecified, column chromatography
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Substance:
4-Hydroxybenzoic acid (RF-00008325-PAR)
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Additional substance description:
p-Hydroxybenzoic acid
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Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
4-Hydroxybenzoic acid in above-ground and underground parts
Composition #3: Swiatek, L., Grabias, B., Rozga, M. Phenolic acids and coumarins in Lithospermum arvense L. and Lycopus europaeus L. herba polonica, 1987, vol. 33, no. 2, p. 87–97. .
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Plant part:
Unspecified (A07XD)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
unspecified, column chromatography
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Substance:
coumarins (RF-00004351-PAR)
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Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Coumarins in above-ground and underground parts
Composition #4: Swiatek, L., Grabias, B., Rozga, M. Phenolic acids and coumarins in Lithospermum arvense L. and Lycopus europaeus L. herba polonica, 1987, vol. 33, no. 2, p. 87–97. .
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Plant part:
Unspecified (A07XD)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
unspecified, column chromatography
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Substance:
p-coumaric acid (RF-00010717-PAR)
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Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
(E)-p-Coumaric acid in above-ground and underground parts
Composition #5: Fecka, I., Cisowski, W. Multiple gradient development TLC in analysis of complex phenolic acids from Lycopus europaeus L. . chromatographia, 1999, vol. 49, no. 5-6, p. 256–260. DOI: 10.1007/BF02467553.
[
DOI link]
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Plant part:
Unspecified (A07XD)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Diethyl ether. Followed by enzyme (beta-glucosidase) or alkaline hydrolysis.
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Substance:
p-coumaric acid (RF-00010717-PAR)
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Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
p-coumaric acid in plant extract and extract after alkaline hydrolysis
Composition #6: Fecka, I., Cisowski, W. Multiple gradient development TLC in analysis of complex phenolic acids from Lycopus europaeus L. . chromatographia, 1999, vol. 49, no. 5-6, p. 256–260. DOI: 10.1007/BF02467553.
[
DOI link]
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Plant part:
Unspecified (A07XD)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Diethyl ether. Followed by enzyme (beta-glucosidase) or alkaline hydrolysis.
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Substance:
3,4-Dihydroxybenzoic acid (RF-00008853-PAR)
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Additional substance description:
Protocatechuic Acid
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Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Protocatechuic (3,4-dihydroxybenzoic) acid in plant extract and extract after alkaline or enzyme hydrolysis
Composition #7: Fecka, I., Cisowski, W. Multiple gradient development TLC in analysis of complex phenolic acids from Lycopus europaeus L. . chromatographia, 1999, vol. 49, no. 5-6, p. 256–260. DOI: 10.1007/BF02467553.
[
DOI link]
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Plant part:
Unspecified (A07XD)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Diethyl ether. Followed by enzyme (beta-glucosidase) or alkaline hydrolysis.
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Substance:
4-Hydroxybenzoic acid (RF-00008325-PAR)
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Additional substance description:
p-hydroxybenzoic acid
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Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
p-hydroxybenzoic acid in plant extract and extract after alkaline hydrolysis
Endpoint study
#1: Hamann, I., Seidlova-Wuttke, D., Wuttke, W., Köhrle, J. Effects of isoflavonoids and other plant-derived compounds on the hypothalamus-pituitary-thyroid hormone axis. maturitas, 2006, vol. 55, no. SUPPL. 1, p. S14–S25. DOI: 10.1016/j.maturitas.2006.06.013.
[
DOI link]
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Study relevance:
Human health
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Substance:
Isoflavonoids Isoflavonoids (RF-00000439-NTR)
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Plant part:
Unspecified (A07XD)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Type of toxicological test:
not reported (CHD015TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Control groups used:
no data
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
ENDOCRINE (TOX12A)
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Target tissue:
glandular: Thyroid (TT033A)
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Effect description:
Long lasting decrease of T3 levels in rats after oral application in spite of reduced TSH serum levels, presumably as a consequence of a reduced peripheral T4 deiodination
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Effect or parameter linked to the endpoint:
no data (CHD002BE)
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Internal remarks:
Thyroid hormone effects in rats (review)