Draft - work in progress
-
- Lophophora williamsii (Lem. Ex Salm-Dyck) J.M.Coult. (as plant) // Lophophora lewinii (Hennings ex Lewin) C.H. Thomps. // Lophophora williamsii (Lem. ex Salm-Dyck) J.M.Coult.
Lophophora williamsii (Lem. Ex Salm-Dyck) J.M.Coult. (as plant) // Lophophora lewinii (Hennings ex Lewin) C.H. Thomps. // Lophophora williamsii (Lem. ex Salm-Dyck) J.M.Coult.
- Family:
- Cactaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 195
- Number of processed references:
- 6
Composition #1: Bruhn, Jan G., El-Seedi, Hesharn R., Stephanson, Nikolai., Beck, Olof., Shulgin, Alexander T. Ecstasy analogues found in cacti. journal of psychoactive drugs, 2008, vol. 40, no. 2, p. 219–222. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Substance:
homopiperonylamine (RF-00003869-PAR)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
homopiperonylamine
Composition #2: Bruhn, Jan G., El-Seedi, Hesharn R., Stephanson, Nikolai., Beck, Olof., Shulgin, Alexander T. Ecstasy analogues found in cacti. journal of psychoactive drugs, 2008, vol. 40, no. 2, p. 219–222. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Substance:
lophophine (RF-00003907-PAR)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Lophophine
Composition #3: Bruhn, Jan G., El-Seedi, Hesharn R., Stephanson, Nikolai., Beck, Olof., Shulgin, Alexander T. Ecstasy analogues found in cacti. journal of psychoactive drugs, 2008, vol. 40, no. 2, p. 219–222. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Substance:
lobivine (RF-00003906-PAR)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Lobivine
Composition #4: Aragane, Masako., Sasaki, Yohei., Nakajima, Jun'ichi., Fukumori, Nobutaka., Yoshizawa, Masao., Suzuki, Yukiko., Kitagawa, Shigemi., Mori, Ken'ichiro., Ogino, Shuzo., Yasuda, Ichiro., Nagumo, Seiji. Peyote identification on the basis of differences in morphology, mescaline content, and trnL/trnF sequence between Lophophora williamsii and L. diffusa . journal of natural medicines, 2011, vol. 65, no. 1, p. 103–110. DOI: 10.1007/s11418-010-0469-7.
[
DOI link]
-
-
Plant part:
Stem / stalk (as part-nature) (A067S)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ultrasonication with 20 ml of 0.1 N HCl
-
Substance:
mescaline (RF-00003925-PAR)
-
Analytical method code:
HPLC with standard detection methods (F019A)
-
Result unit:
Milligram/gram (G060A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
12.7 - 48.3
-
Internal remarks:
Mescaline in stem
Composition #5: Klein, Molly T., Kalam, M., Trout, Keeper., Fowler, Norma., Terry, Martin. MESCALINE CONCENTRATIONS IN THREE PRINCIPAL TISSUES OF LOPHOPHORA WILLIAMSII (CACTACEAE): IMPLICATIONS FOR SUSTAINABLE HARVESTING PRACTICES . haseltonia, 2015, no. 20, p. 34–42. .
-
-
Plant part:
Live plants (as part-nature) (A0BA0)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
-
Substance:
mescaline (RF-00003925-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.0147 - 5.50
-
Internal remarks:
Mescaline in crown (1.82 - 5.5%), stem (0.118 - 0.376%) and root (0.0147 - 0.0773%).
Composition #6: HELMLIN, HJ., BOURQUIN, D., BRENNEISEN, R. DETERMINATION OF PHENYLETHYLAMINES IN HALLUCINOGENIC CACTUS SPECIES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH PHOTODIODE-ARRAY DETECTION . journal of chromatography, 1992, vol. 623, no. 2, p. 381–385. DOI: 10.1016/0021-9673(92)80380-D.
[
DOI link]
-
-
Plant part:
Live plants (as part-nature) (A0BA0)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Extraction with diethylether and 33% methanol-ammonia (99:1)
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Additional substance description:
N-methylmescaline, isopellotine, pellotine and anhalonine
-
Analytical method code:
HPLC-DAD (F587A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
N-methylmescaline, isopellotine, pellotine and anhalonine in cactus.
Composition #7: HELMLIN, HJ., BOURQUIN, D., BRENNEISEN, R. DETERMINATION OF PHENYLETHYLAMINES IN HALLUCINOGENIC CACTUS SPECIES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH PHOTODIODE-ARRAY DETECTION . journal of chromatography, 1992, vol. 623, no. 2, p. 381–385. DOI: 10.1016/0021-9673(92)80380-D.
[
DOI link]
-
-
Plant part:
Live plants (as part-nature) (A0BA0)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Extraction with diethylether and 33% methanol-ammonia (99:1)
-
Substance:
mescaline (RF-00003925-PAR)
-
Analytical method code:
HPLC-DAD (F587A)
-
Result unit:
Milligram/100 gram (G057A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
680 - 1010
-
Internal remarks:
Mescaline in cactus
Composition #8: HELMLIN, HJ., BOURQUIN, D., BRENNEISEN, R. DETERMINATION OF PHENYLETHYLAMINES IN HALLUCINOGENIC CACTUS SPECIES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH PHOTODIODE-ARRAY DETECTION . journal of chromatography, 1992, vol. 623, no. 2, p. 381–385. DOI: 10.1016/0021-9673(92)80380-D.
[
DOI link]
-
-
Plant part:
Live plants (as part-nature) (A0BA0)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Extraction with diethylether and 33% methanol-ammonia (99:1)
-
Substance:
Isoquinoline alkaloids (RF-00004391-PAR)
-
Additional substance description:
anhalamine and anhalonidine
-
Analytical method code:
HPLC-DAD (F587A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
anhalamine and anhalonidine in cactus.
Composition #9: Gennaro, MC., Gioannini, E., Giacosa, D., Siccardi, D. Determination of mescaline in hallucinogenic Cactaceae by ion-interaction HPLC. . analytical letters, 1996, vol. 29, no. 13, p. 2399–2409. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Fresh (A166Y)
-
Substance:
mescaline (RF-00003925-PAR)
-
Additional substance description:
mescaline found in Lophophora williamsii and in Trichocereus pachanoi were respectively 2.55 mg and 3.10 mg/g of fresh cactus
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Result unit:
Milligram/gram (G060A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
2.55
-
Internal remarks:
mescaline 2.55 mg/g of fresh cactus
Endpoint study
#1: Carstairs, Shaun D., Cantrell, F. Lee. Peyote and mescaline exposures: a 12-year review of a statewide poison center database . clinical toxicology, 2010, vol. 48, no. 4, p. 350–353. DOI: 10.3109/15563650903586745.
[
DOI link]
-
Study relevance:
Human health
-
Substance:
mescaline (RF-00003925-PAR)
-
Type of toxicological test:
case report (CHD060TT)
-
Tested organism:
Human (as organism) (A056J)
-
-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
-
Number of organisms dosed:
31
-
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Effect description:
most common effects hallucinations, tachycardia, agitation, and mydriasis. Vomiting was reported in only one case.
-
Effect or parameter linked to the endpoint:
neurology (CHD027BE)
-
Internal remarks:
31 cases of ingestion causing mild to moderate toxicity ( hallucinations, tachycardia, agitation, and mydriasis. Vomiting was reported in only one case)