EFSA Compendium of Botanicals

Endpoint study #1: Zhang, Zhong., Luo, Aimin., Zhong, Kai., Huang, Yina., Gao, Yuan., Zhang, Jun., Gao, Hong., Xu, Zhengjun., Gao, Xiaoling. alpha-Glucosidase inhibitory activity by the flower buds of Lonicera japonica Thunb . journal of functional foods, 2013, vol. 5, no. 3, p. 1253–1259. DOI: 10.1016/j.jff.2013.04.008. [DOI link]

Study relevance:

Human health
Plant part:

Bud (as part-nature) (A066Z)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanol 50%
Type of toxicological test:

acute toxicity (CHD016TT)
Limit test:

Not applicable
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Sprague-Dawley (CHD012ST)
Sex:

Male
Route of exposure:

OTHER (OECD0PL)
Exposure duration:

1.0
Unit of exposure duration:

Meal (G109A)
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Microgram/millilitre (G052A)
Effect concentration:

223
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

in rat intestinal alpha glucosidase inhibition IC50
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha glucosidase inhibition in rat

Lonicera japonica Thunb.