EFSA Compendium of Botanicals

Draft - work in progress

Litsea cubeba (Lour.) Pers.

Family:: Lauraceae
Approval state:: Approved
Number of articles retrieved:: 1195
Number of processed references:: 7

Compositions

#1: camphor in essential oil from root #2: naphthalene in essential oil from root #3: naphthalene derivatives in branch #4: dopamine derivatives in branch #5: benzoquinones in branch #6: tyramine derivatives in branch #7: 1,8-cineole in leaves #8: myrcene in leaves #9: Myrcene in stem #10: pulegone in stems #11: Camphor in roots #12: Myrcene in roots #13: Myrcene in fruit #14: Myrcene in leaf #15: Aporphine alkaloids in unspecified part #16: (–)-N-methoxycarbonyl-norjuziphine in leaves #17: isoquinoline alkaloids in dried stems

Endpoint Studies

Genotoxicity

Composition #1: Fu, Shuiyu., Huang, Aijin., Liu, Huwei., Sun, Yiliang., Wu, Qiang., Xia, Yuyu. Studies of the fragrance volatile and essential oil components of Litsea cubeba root. beijing daxue xuebao, ziran kexueban, 1992, vol. 28, no. 4, p. 460–7. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.33
Internal remarks:

camphor in essential oil from root

Composition #2: Fu, Shuiyu., Huang, Aijin., Liu, Huwei., Sun, Yiliang., Wu, Qiang., Xia, Yuyu. Studies of the fragrance volatile and essential oil components of Litsea cubeba root. beijing daxue xuebao, ziran kexueban, 1992, vol. 28, no. 4, p. 460–7. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Naphthalene (RF-0801-001-PPP)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

12.64
Internal remarks:

naphthalene in essential oil from root

Composition #3: Chen, Z.-J., Bi, H.-P., Fan, C.-J., Bao, C.-Y. Chemical constituents from the branch of Litsea cubeba (Lour.) Pers.. chemistry and industry of forest products, 2013, vol. 33, no. 4, p. 133–136. DOI: 10.3969/j.issn.0253-2417.2013.04.025. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95 %
Substance:

Naphthalene derivatives (RF-00010833-PAR)
Additional substance description:

1, 2-dihydro-6, 8-dimethoxy-7-1-(3, 5-dimethoxy-4-hydroxyphenyl)-N1, N2-bis-[2-(4-hydroxyphenyl)ethyl]-2, 3-naphthalene dicarboxamide
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

column chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

naphthalene derivatives in branch

Composition #4: Chen, Z.-J., Bi, H.-P., Fan, C.-J., Bao, C.-Y. Chemical constituents from the branch of Litsea cubeba (Lour.) Pers.. chemistry and industry of forest products, 2013, vol. 33, no. 4, p. 133–136. DOI: 10.3969/j.issn.0253-2417.2013.04.025. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95 %
Substance:

dopamine (RF-00000076-NTR)
Additional substance description:

dopamine derivative: N-transferuloyl-3-methyldopamine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

column chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

dopamine derivatives in branch

Composition #5: Chen, Z.-J., Bi, H.-P., Fan, C.-J., Bao, C.-Y. Chemical constituents from the branch of Litsea cubeba (Lour.) Pers.. chemistry and industry of forest products, 2013, vol. 33, no. 4, p. 133–136. DOI: 10.3969/j.issn.0253-2417.2013.04.025. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95 %
Substance:

benzoquinones (RF-00010840-PAR)
Additional substance description:

dimetoxybenzoquinone
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

column chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

benzoquinones in branch

Composition #6: Chen, Z.-J., Bi, H.-P., Fan, C.-J., Bao, C.-Y. Chemical constituents from the branch of Litsea cubeba (Lour.) Pers.. chemistry and industry of forest products, 2013, vol. 33, no. 4, p. 133–136. DOI: 10.3969/j.issn.0253-2417.2013.04.025. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95 %
Substance:

Tyramine (RF-00000007-BGA)
Additional substance description:

tyramine derivatives : N-trans-feruloyl tyramine, N-p-coumaroyltyramine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

column chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tyramine derivatives in branch

Composition #7: Bighelli, A., Muselli, A., Casanova, J., Tam, NT., Van Anh, V., Bessiere, JM. Chemical variability of Litsea cubeba leaf oil from Vietnam. journal of essential oil research, 2005, vol. 17, no. 1, p. 86–88. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.2 - 51.7
Internal remarks:

1,8-cineole in leaves

Composition #8: Bighelli, A., Muselli, A., Casanova, J., Tam, NT., Van Anh, V., Bessiere, JM. Chemical variability of Litsea cubeba leaf oil from Vietnam. journal of essential oil research, 2005, vol. 17, no. 1, p. 86–88. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.6 - 2.0
Internal remarks:

myrcene in leaves

Composition #9: Son, Le C., Dai, Do N., Thang, Tran D., Huyen, Duong D., Ogunwande, Isiaka A. Analysis of the Essential Oils from Five Vietnamese Litsea Species (Lauraceae) . journal of essential oil bearing plants, 2014, vol. 17, no. 5, p. 960–971. DOI: 10.1080/0972060X.2014.935068. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

Gas chromatography coupled with Mass spectrometry (GC-MS)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.3
Internal remarks:

Myrcene in stem

Composition #10: Son, Le C., Dai, Do N., Thang, Tran D., Huyen, Duong D., Ogunwande, Isiaka A. Analysis of the Essential Oils from Five Vietnamese Litsea Species (Lauraceae) . journal of essential oil bearing plants, 2014, vol. 17, no. 5, p. 960–971. DOI: 10.1080/0972060X.2014.935068. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

(+)-pulegone (RF-00003398-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

Gas chromatography coupled with Mass spectrometry (GC-MS)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.4
Internal remarks:

pulegone in stems

Composition #11: Son, Le C., Dai, Do N., Thang, Tran D., Huyen, Duong D., Ogunwande, Isiaka A. Analysis of the Essential Oils from Five Vietnamese Litsea Species (Lauraceae) . journal of essential oil bearing plants, 2014, vol. 17, no. 5, p. 960–971. DOI: 10.1080/0972060X.2014.935068. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

Gas chromatography coupled with Mass spectrometry (GC-MS)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.1
Internal remarks:

Camphor in roots

Composition #12: Son, Le C., Dai, Do N., Thang, Tran D., Huyen, Duong D., Ogunwande, Isiaka A. Analysis of the Essential Oils from Five Vietnamese Litsea Species (Lauraceae) . journal of essential oil bearing plants, 2014, vol. 17, no. 5, p. 960–971. DOI: 10.1080/0972060X.2014.935068. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

Gas chromatography coupled with Mass spectrometry (GC-MS)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.4
Internal remarks:

Myrcene in roots

Composition #13: Son, Le C., Dai, Do N., Thang, Tran D., Huyen, Duong D., Ogunwande, Isiaka A. Analysis of the Essential Oils from Five Vietnamese Litsea Species (Lauraceae) . journal of essential oil bearing plants, 2014, vol. 17, no. 5, p. 960–971. DOI: 10.1080/0972060X.2014.935068. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

Gas chromatography coupled with Mass spectrometry (GC-MS)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.0
Internal remarks:

Myrcene in fruit

Composition #14: Son, Le C., Dai, Do N., Thang, Tran D., Huyen, Duong D., Ogunwande, Isiaka A. Analysis of the Essential Oils from Five Vietnamese Litsea Species (Lauraceae) . journal of essential oil bearing plants, 2014, vol. 17, no. 5, p. 960–971. DOI: 10.1080/0972060X.2014.935068. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

Gas chromatography coupled with Mass spectrometry (GC-MS)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.0
Internal remarks:

Myrcene in leaf

Composition #15: Sun, Changlei., Li, Jia., Wang, Daijie., Yu, Jinqian., Wang, Xiao., Huang, Luqi. Preparative separation of alkaloids from Litsea cubeba using combined applications of pH-zone-refining and high-speed counter-current chromatography . rsc advances, 2015, vol. 5, no. 92, p. 75831–75837. DOI: 10.1039/c5ra10564a. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

Aporphine alkaloids (RF-00010806-PAR)
Additional substance description:

laurolitsine, boldine, laurotetanine, reticuline, isoboldine and norisocorydine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Aporphine alkaloids in unspecified part

Composition #16: Tang, Bin., Tu, Hua., Long, Han-An., Du, Jun., Guo, Jian-Min., Liu, Hong-Jin., Hu, Xin., Yang, Li., Du, Xi. A new N-methoxyl-carbonyl benzylisoquinoline from Litsea cubeba. journal of asian natural products research, 2017, vol. 19, no. 9, p. 941–945. DOI: 10.1080/10286020.2016.1275582. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

(–)-N-methoxycarbonyl-norjuziphine
Analytical method code:

Element spectroscopy (F051A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

(–)-N-methoxycarbonyl-norjuziphine in leaves

Composition #17: LEE, SS., CHEN, CK., CHEN, IS., LIU, KCS. ADDITIONAL ISOQUINOLINE ALKALOIDS FROM LITSEA-CUBEBA. journal of the chinese chemical society, 1992, vol. 39, no. 5, p. 453–455. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol extract of dried powdered stems
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

isocorydine, N-methyllaurotetaninc, boldine, laurolitsine, laurotetanine, isoboldine, norisocorydine, N-mcthyllindcarpine, isodomesticine, and glaziovine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR and TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

isoquinoline alkaloids in dried stems