EFSA Compendium of Botanicals

Draft - work in progress

Lippia integrifolia (Griseb.) Hieron.

Family:: Verbenaceae
Approval state:: Approved
Number of articles retrieved:: 54
Number of processed references:: 4

Compositions

#1: eucalyptol (1,8-cineole) in leaves #2: Beta-selinene oxide in essential oil #3: Methyl-isoeugenol in essential oil #4: Camphor in essential oil #5: Camphor in flowers #6: alpha-thujone in flowers #7: Carvone in flowers #8: Camphor in aerial parts

Endpoint Studies

Genotoxicity

Composition #1: Canosa, J. Fernandez. Lippia integrifolia. revista de la asociacion bioquimica argentina, 1953, vol. 18, p. 225–30. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

distillation
Substance:

1,8-cineole (RF-00003470-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

eucalyptol (1,8-cineole) in leaves

Composition #2: Velasco-Negueruela, A., Pérez-Alonso, M.J., Guzmán, C.A., Zygadlo, J.A., Ariza-Espinar, L., Sanz, J., García-Vallejo, M.C. Volatile constitutents of four Lippia species from córdoba (Argentina). journal of essential oil research, 1993, vol. 5, no. 5, p. 513–524. DOI: 10.1080/10412905.1993.9698272. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

beta-selinene (RF-00011306-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.42
Internal remarks:

Beta-selinene oxide in essential oil

Composition #3: Velasco-Negueruela, A., Pérez-Alonso, M.J., Guzmán, C.A., Zygadlo, J.A., Ariza-Espinar, L., Sanz, J., García-Vallejo, M.C. Volatile constitutents of four Lippia species from córdoba (Argentina). journal of essential oil research, 1993, vol. 5, no. 5, p. 513–524. DOI: 10.1080/10412905.1993.9698272. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

methylisoeugenol (RF-00003493-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.17
Internal remarks:

Methyl-isoeugenol in essential oil

Composition #4: Velasco-Negueruela, A., Pérez-Alonso, M.J., Guzmán, C.A., Zygadlo, J.A., Ariza-Espinar, L., Sanz, J., García-Vallejo, M.C. Volatile constitutents of four Lippia species from córdoba (Argentina). journal of essential oil research, 1993, vol. 5, no. 5, p. 513–524. DOI: 10.1080/10412905.1993.9698272. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

(-)-camphor (RF-00003469-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

16.20
Internal remarks:

Camphor in essential oil

Composition #5: Zygadlo, J.A., Lamarque, A.L., Guzman, C.A., Grosso, N.R. Composition of the flower oils of some lippia and aloysia species from Argentina. journal of essential oil research, 1995, vol. 7, no. 6, p. 593–595. DOI: 10.1080/10412905.1995.9700512. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

18.5
Internal remarks:

Camphor in flowers

Composition #6: Zygadlo, J.A., Lamarque, A.L., Guzman, C.A., Grosso, N.R. Composition of the flower oils of some lippia and aloysia species from Argentina. journal of essential oil research, 1995, vol. 7, no. 6, p. 593–595. DOI: 10.1080/10412905.1995.9700512. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

alpha-thujone (RF-00003676-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.00
Internal remarks:

alpha-thujone in flowers

Composition #7: Zygadlo, J.A., Lamarque, A.L., Guzman, C.A., Grosso, N.R. Composition of the flower oils of some lippia and aloysia species from Argentina. journal of essential oil research, 1995, vol. 7, no. 6, p. 593–595. DOI: 10.1080/10412905.1995.9700512. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

Carvone (RF-0538-001-PPP)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.00
Internal remarks:

Carvone in flowers

Composition #8: Marcial, Guillermo., de Lampasona, Marina P., Vega, Marta I., Lizarraga, Emilio., Viturro, Carmen I., Slanis, Alberto., Juarez, Miguel A., Elechosa, Miguel A., Catalan, Cesar A. N. Intraspecific variation in essential oil composition of the medicinal plant Lippia integrifolia (Verbenaceae). Evidence for five chemotypes . phytochemistry, 2016, vol. 122, p. 203–212. DOI: 10.1016/j.phytochem.2015.11.004. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

(-)-camphor (RF-00003469-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<= 1.6
Internal remarks:

Camphor in aerial parts