Draft - work in progress
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- Leonurus japonicus Houtt. // Leonurus heterophyllus Sweet
Leonurus japonicus Houtt. // Leonurus heterophyllus Sweet
- Family:
- Lamiaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 897
- Number of processed references:
- 5
Composition #1: He, C.-J., Peng, C., Dai, O., Yang, L., Liu, J., Guo, L., Xiong, L., Liu, Z.-H. Chemical constituents from Leonurus japonicus Injection. chinese traditional and herbal drugs, 2014, vol. 45, no. 21, p. 3048–3052. DOI: 10.7501/j.issn.0253-2670.2014.21.002.
[
DOI link]
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Plant part:
Unspecified (A07XD)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
unspecified
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Substance:
Alkaloids (RF-00004360-PAR)
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Additional substance description:
stachydrine, choline, trigonelline, uracil and derivatives, 2', 3'-O-isopropylidene uridine, hydroxypyridine and derivatives
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
spectroscopic analysis + NMR
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Alkaloids
Composition #2: Chao, Zhi., Ma, Li-ling., Zhou, Xiu-jia. Determination of stachydrine and leonurine in Herba Leonuri by ion- pair reversed-phase high-performance liquid chromatography . . di 1 jun yi da xue xue bao = academic journal of the first medical college of pla, 2004, vol. 24, no. 11, p. 1223–6. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ethanol
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Substance:
stachydrine (RF-00004062-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.1-0.2
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Internal remarks:
Stachydrine in aerial parts
Composition #3: Chao, Zhi., Ma, Li-ling., Zhou, Xiu-jia. Determination of stachydrine and leonurine in Herba Leonuri by ion- pair reversed-phase high-performance liquid chromatography . . di 1 jun yi da xue xue bao = academic journal of the first medical college of pla, 2004, vol. 24, no. 11, p. 1223–6. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ethanol
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Substance:
Alkaloids (RF-00004360-PAR)
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Additional substance description:
Total alkaloids
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.3
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Internal remarks:
total alkaloids in aerial parts
Composition #4: Yang, Huai., Zhou, Qin-mei., Peng, Cheng., Liu, Lu-si., Xie, Xiao-fang., Xiong, Liang., Liu, Zhao-hua. Coumarins from Leonurus japonicus and their anti-platelet aggregative activity . . zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica, 2014, vol. 39, no. 22, p. 4356–9. .
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Plant part:
Unspecified (A07XD)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
unspecified
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Substance:
coumarins (RF-00004351-PAR)
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Additional substance description:
bergapten, xanthotoxin, isopimpinellin, isogosferal, imperatorin, meranzin and derivatives, murrayone , auraptenol, and osthol
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Analytical method code:
Chromatographic tests (F015A)
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Analytical method - additional description:
Various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, MCI, and Rp C18
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Coumarins (plant part not specified)
Composition #5: Moon, Hyung-In. Three Diterpenes from Leonurus japonicus Houtt Protect Primary Cultured Rat Cortical Cells from Glutamate-induced Toxicity . phytotherapy research, 2010, vol. 24, no. 8, p. 1256–1259. DOI: 10.1002/ptr.3144.
[
DOI link]
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Plant part:
Unspecified (A07XD)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol
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Substance:
labdane diterpenes (RF-00004392-PAR)
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Additional substance description:
prehispanolone, leojaponin, iso-preleoheterin
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
NMR, TLC
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Labdane diterpenes (prehispanolone, leojaponin, iso-preleoheterin)
Composition #6: Seo, Hyun Kyu., Kim, Ju Sun., Kang, Sam Sik. Labdane Diterpenes and Flavonoids from Leonurus japonicus. helvetica chimica acta, 2010, vol. 93, no. 10, p. 2045–2051. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
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Substance:
labdane diterpenes (RF-00004392-PAR)
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Additional substance description:
3a-acetoxy-15-O-methylleopersin C, leosibirinone A
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
NMR, HR-FAB-MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
labdane diterpenes (leosibirinone A, 3a-acetoxy-15-O-methylleopersin C) in aerial parts
