EFSA Compendium of Botanicals

Draft - work in progress

Lamprocapnos spectabilis (L.) Fukuhara // Dicentra spectabilis (L.) Lem.

Family:: Papaveraceae
Approval state:: Approved
Number of articles retrieved:: 97
Number of processed references:: 4

Compositions

#1: Alkaloids (protopine, sanguinarine, cheilanthifoline, scoulerine and corydine) in roots #2: Alkaloids (protopine, sanguinarine, dihydrosanguinarine, scoulerine and corydine) in aerial part #3: Sanguinarine in plants #4: Protopine in plants #5: Benzofurans (menisdaurilide and aquilegiolide) in aerial parts #6: p-coumaric acid in aerial parts

Endpoint Studies

Genotoxicity

Composition #1: Israilov, I.A., Melikov, F.M., Murav'eva, D.A. Alkaloids of Dicentra. chemistry of natural compounds, 1984, vol. 20, no. 1, p. 74–76. DOI: 10.1007/BF00574796. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol followed by ether and/or chloroform
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

protopine, sanguinarine, cheilanthifoline, scoulerine and corydine
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

MS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.25
Internal remarks:

Alkaloids (protopine, sanguinarine, cheilanthifoline, scoulerine and corydine) in roots

Composition #2: Israilov, I.A., Melikov, F.M., Murav'eva, D.A. Alkaloids of Dicentra. chemistry of natural compounds, 1984, vol. 20, no. 1, p. 74–76. DOI: 10.1007/BF00574796. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol followed by ether and/or chloroform
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

protopine, sanguinarine, dihydrosanguinarine, scoulerine and corydine
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

MS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.17
Internal remarks:

Alkaloids (protopine, sanguinarine, dihydrosanguinarine, scoulerine and corydine) in aerial part

Composition #3: Och, Anna., Szewczyk, Katarzyna., Pecio, Lukasz., Stochmal, Anna., Zaluski, Daniel., Bogucka-Kocka, Anna. UPLC-MS/MS Profile of Alkaloids with Cytotoxic Properties of Selected Medicinal Plants of the Berberidaceae and Papaveraceae Families. . oxidative medicine and cellular longevity, 2017, vol. 2017, p. 9369872–9369872. DOI: 10.1155/2017/9369872. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

sanguinarine (RF-00004040-PAR)
Analytical method code:

UHPLC-MS-MS (F608A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1104.6-1106.6
Internal remarks:

Sanguinarine in plants

Composition #4: Och, Anna., Szewczyk, Katarzyna., Pecio, Lukasz., Stochmal, Anna., Zaluski, Daniel., Bogucka-Kocka, Anna. UPLC-MS/MS Profile of Alkaloids with Cytotoxic Properties of Selected Medicinal Plants of the Berberidaceae and Papaveraceae Families. . oxidative medicine and cellular longevity, 2017, vol. 2017, p. 9369872–9369872. DOI: 10.1155/2017/9369872. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

protopine (RF-00004010-PAR)
Analytical method code:

UHPLC-MS-MS (F608A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

11890-11908
Internal remarks:

Protopine in plants

Composition #5: McNulty, James., Poloczek, Joanna., Larichev, Vladimir., Werstiuk, Nick H., Griffin, Carly., Pandey, Siyaram. Discovery of the apoptosis-inducing activity and high accumulation of the butenolides, menisdaurilide and aquilegiolide, in Dicentra spectabilis . planta medica, 2007, vol. 73, no. 15, p. 1543–1547. DOI: 10.1055/s-2007-990264. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform and methanol
Substance:

Benzofurans (RF-00010791-PAR)
Additional substance description:

menisdaurilide and aquilegiolide
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

Also, TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Benzofurans (menisdaurilide and aquilegiolide) in aerial parts

Composition #6: BOEGGE, SC., NAHRSTEDT, A., LINSCHEID, M., NIGGE, W. DISTRIBUTION AND STEREOCHEMISTRY OF HYDROXYCINNAMOYLMALIC ACIDS AND OF FREE MALIC-ACIDS IN PAPAVERACEAE AND FUMARIACEAE . zeitschrift fur naturforschung c-a journal of biosciences, 1995, vol. 50, no. 9-10, p. 608–615. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol/water (3:2 v/v)
Substance:

p-coumaric acid (RF-00010717-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.12
Internal remarks:

p-coumaric acid in aerial parts