EFSA Compendium of Botanicals

Draft - work in progress

Rhatany (as plant) // Krameria lappacea (Dombey) Burdet & B.B.Simpson // Krameria triandra Ruiz & Pav.

Family:: Krameriaceae
Approval state:: Approved
Number of articles retrieved:: 69
Number of processed references:: 4

Compositions

#1: lignans in roots #2: proanthocyanidins in roots #3: tannins in roots #4: tannins in roots #5: coumarins in roots #6: Lignans in roots

Endpoint Studies

Genotoxicity

Composition #1: Maffei Facino, R., Carini, M., Aldini, G., De Angelis, L. A rapid screening by liquid chromatography/mass spectrometry and fast-atom bombardment tandem mass spectrometry of phenolic constituents with radical scavenging activity, from Krameria triandra roots . rapid communications in mass spectrometry, 1997, vol. 11, no. 12, p. 1303–1308. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone:H2O (8:2)
Substance:

lignans (RF-00004361-PAR)
Analytical method code:

LC-MS (F026A)
Analytical method - additional description:

Liquid chromatography/mass spectrometry
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lignans in roots

Composition #2: Møller, C., Hansen, S.H., Cornett, C. Characterisation of tannin-containing herbal drugs by HPLC. phytochemical analysis, 2009, vol. 20, no. 3, p. 231–239. DOI: 10.1002/pca.1119. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

H2O
Substance:

Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
Substance used for equivalence:

Catechin (RF-00010400-PAR)
Analytical method code:

HPLC-FD (F022A)
Result unit:

Per mille (G083A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.35-1.89
Internal remarks:

proanthocyanidins in roots

Composition #3: Møller, C., Hansen, S.H., Cornett, C. Characterisation of tannin-containing herbal drugs by HPLC. phytochemical analysis, 2009, vol. 20, no. 3, p. 231–239. DOI: 10.1002/pca.1119. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

The aqueous extract
Substance:

Tannins (RF-00004337-PAR)
Substance used for equivalence:

Pyrogallol (RF-00010702-PAR)
Analytical method code:

Unspecified (F598A)
Analytical method - additional description:

according to Ph. Eur. 2.8.14
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.1 - 7.0
Internal remarks:

tannins in roots

Composition #4: Pascual, ME., Carretero, ME., Slowing, KV., Villar, A. Simplified screening by TLC of plant drugs. pharmaceutical biology, 2002, vol. 40, no. 2, p. 139–143. DOI: 10.1076/phbi.40.2.139.5849. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane, dichloromethane and ethanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tannins in roots

Composition #5: Pascual, ME., Carretero, ME., Slowing, KV., Villar, A. Simplified screening by TLC of plant drugs. pharmaceutical biology, 2002, vol. 40, no. 2, p. 139–143. DOI: 10.1076/phbi.40.2.139.5849. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane, dichloromethane and ethanol
Substance:

coumarins (RF-00004351-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

coumarins in roots

Composition #6: Baumgartner, Lisa., Sosa, Silvio., Atanasov, Atanas G., Bodensieck, Antje., Fakhrudin, Nanang., Bauer, Julia., Del Favero, Giorgia., Ponti, Cristina., Heiss, Elke H., Schwaiger, Stefan., Ladurner, Angela., Widowitz, Ute., Della Loggia, Roberto., Rollinger, Judith M., Werz, Oliver., Bauer, Rudolf., Dirsch, Verena M., Tubaro, Aurelia., Stuppner, Hermann. Lignan Derivatives from Krameria lappacea Roots Inhibit Acute Inflammation in Vivo and Pro-inflammatory Mediators in Vitro . journal of natural products, 2011, vol. 74, no. 8, p. 1779–1786. DOI: 10.1021/np200343t. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ch2Cl2
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

11 lignan derivatives, comprising neolignans, norneolignans, and 7,70 -epoxy lignans
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

ms
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans in roots