EFSA Compendium of Botanicals

Draft - work in progress

Ipomoea purga (Wender.) Hayne // Exogonium purga (Wender.) Benth.

Family:: Convolvulaceae
Approval state:: Approved
Number of articles retrieved:: 43
Number of processed references:: 3

Compositions

#1: Resins #2: Glucoresins in leaves #3: Lysergol in stem #4: Glucoresins in seeds #5: Glucoresins in stem #6: Glucoresins in roots #7: Lysergol in roots #8: Lysergol in seed

Endpoint Studies

#1: Laxative effect #2: Laxative effect of the plant

Genotoxicity

Composition #1: Meira, M., da Silva, E.P., David, J.M., David, J.P. Review of the genus Ipomoea: Traditional uses, chemistry and biological activities. brazilian journal of pharmacognosy, 2012, vol. 22, no. 3, p. 682–713. DOI: 10.1590/S0102-695X2012005000025. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

resin
Substance:

Glucoresins (RF-00004385-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Resins

Composition #2: Argaez, AG., PerezAmador, MC. Distribution in the plant of glycoresins and ergoline alkaloids in three species of Ipomoea (Convolvulaceae) . phyton-international journal of experimental botany, 1997, vol. 60, p. 73–76. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane and ethyl acetate
Substance:

Glucoresins (RF-00004385-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Glucoresins in leaves

Composition #3: Argaez, AG., PerezAmador, MC. Distribution in the plant of glycoresins and ergoline alkaloids in three species of Ipomoea (Convolvulaceae) . phyton-international journal of experimental botany, 1997, vol. 60, p. 73–76. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane and ethyl acetate
Substance:

Lysergol (RF-00000408-TOX)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lysergol in stem

Composition #4: Argaez, AG., PerezAmador, MC. Distribution in the plant of glycoresins and ergoline alkaloids in three species of Ipomoea (Convolvulaceae) . phyton-international journal of experimental botany, 1997, vol. 60, p. 73–76. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane and ethyl acetate
Substance:

Glucoresins (RF-00004385-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Glucoresins in seeds

Composition #5: Argaez, AG., PerezAmador, MC. Distribution in the plant of glycoresins and ergoline alkaloids in three species of Ipomoea (Convolvulaceae) . phyton-international journal of experimental botany, 1997, vol. 60, p. 73–76. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane and ethyl acetate
Substance:

Glucoresins (RF-00004385-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Glucoresins in stem

Composition #6: Argaez, AG., PerezAmador, MC. Distribution in the plant of glycoresins and ergoline alkaloids in three species of Ipomoea (Convolvulaceae) . phyton-international journal of experimental botany, 1997, vol. 60, p. 73–76. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Glucoresins (RF-00004385-PAR)
Additional substance description:

purgative resins
Analytical method code:

Traditional analytical techniques (wet chemical tests) (F003A)
Result unit:

Percent (G138A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

21.4
Internal remarks:

Glucoresins in roots

Composition #7: Argaez, AG., PerezAmador, MC. Distribution in the plant of glycoresins and ergoline alkaloids in three species of Ipomoea (Convolvulaceae) . phyton-international journal of experimental botany, 1997, vol. 60, p. 73–76. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane and ethyl acetate
Substance:

Lysergol (RF-00000408-TOX)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lysergol in roots

Composition #8: Argaez, AG., PerezAmador, MC. Distribution in the plant of glycoresins and ergoline alkaloids in three species of Ipomoea (Convolvulaceae) . phyton-international journal of experimental botany, 1997, vol. 60, p. 73–76. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane and ethyl acetate
Substance:

Lysergol (RF-00000408-TOX)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lysergol in seed

Endpoint study #1: Meira, M., da Silva, E.P., David, J.M., David, J.P. Review of the genus Ipomoea: Traditional uses, chemistry and biological activities. brazilian journal of pharmacognosy, 2012, vol. 22, no. 3, p. 682–713. DOI: 10.1590/S0102-695X2012005000025. [DOI link]

Study relevance:

Human health
Substance:

Glucoresins (RF-00004385-PAR)
Type of toxicological test:

not reported (CHD015TT)
Tested organism:

Human (as organism) (A056J)
Endpoint measured:

Dose not reported (CHD066EP)
Target tissue:

Digestive (TT002A)
Effect description:

laxative effect
Effect or parameter linked to the endpoint:

not reported (CHD030BE)
Internal remarks:

Laxative effect

Endpoint study #2: Pereda-Miranda, Rogelio., Fragoso-Serrano, Mabel., Escalante-Sanchez, Edgar., Hernandez-Carlos, Beatriz., Linares, Edelmira., Bye, Robert. Profiling of the resin glycoside content of Mexican jalap roots with purgative activity . journal of natural products, 2006, vol. 69, no. 10, p. 1460–1466. DOI: 10.1021/np060295f. [DOI link]

Study relevance:

Human health
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

Human (as organism) (A056J)
Sex:

No data
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Control groups used:

no data
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

laxative effect / use as purgatives
Effect or parameter linked to the endpoint:

food efficiency (CHD021BE)
Internal remarks:

Laxative effect of the plant