Draft - work in progress
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- Maté (as plant) // Ilex paraguariensis A. St.-Hil.
Maté (as plant) // Ilex paraguariensis A. St.-Hil.
- Family:
- Aquifoliaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 1506
- Number of processed references:
- 7
Composition #1: Otsuka, Rafaela Denise., Lago, Joao Henrique Ghilardi., Rossi, Lucia., Galduroz, Jose Carlos Fernandes., Rodrigues, Eliana. Psychoactive plants described in a Brazilian literary work and their chemical compounds. central nervous system agents in medicinal chemistry, 2010, vol. 10, no. 3, p. 218–237. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Substance:
Diterpenes Diterpenes (RF-00004378-PAR)
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Analytical method code:
Unspecified (F598A)
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Analytical method - additional description:
Noted in review article.
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Diterpenes in leaves
Composition #2: Otsuka, Rafaela Denise., Lago, Joao Henrique Ghilardi., Rossi, Lucia., Galduroz, Jose Carlos Fernandes., Rodrigues, Eliana. Psychoactive plants described in a Brazilian literary work and their chemical compounds. central nervous system agents in medicinal chemistry, 2010, vol. 10, no. 3, p. 218–237. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Substance:
Alkaloids (RF-00004360-PAR)
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Analytical method code:
Unspecified (F598A)
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Analytical method - additional description:
Noted in review article.
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Alkaloids in leaves
Composition #3: Nishiguchi, Yoshikazu., Momose, Yasunori., Chen, Fu-Shih. The analysis on the contents of polyphenolic compounds, catechins, and caffeine in mate (Ilex paraguariensis). igaku to seibutsugaku, 2011, vol. 155, no. 1, p. 35–41. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Substance:
Epicatechin-3-gallate (RF-00010397-PAR)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.0624-0.0789
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Internal remarks:
epicatechin gallate in the leaves
Composition #4: Nishiguchi, Yoshikazu., Momose, Yasunori., Chen, Fu-Shih. The analysis on the contents of polyphenolic compounds, catechins, and caffeine in mate (Ilex paraguariensis). igaku to seibutsugaku, 2011, vol. 155, no. 1, p. 35–41. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Substance:
epigallocatechin gallate (RF-00003802-PAR)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.19-0.204
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Internal remarks:
epigallocatechin gallate in the leaves
Composition #5: Nishiguchi, Yoshikazu., Momose, Yasunori., Chen, Fu-Shih. The analysis on the contents of polyphenolic compounds, catechins, and caffeine in mate (Ilex paraguariensis). igaku to seibutsugaku, 2011, vol. 155, no. 1, p. 35–41. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Substance:
Epigallocatechin (RF-00010399-PAR)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.0139-0.0152
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Internal remarks:
epigallocatechin gallate in the leaves
Composition #6: Marx, F., Janssens, M.J.J., Urfer, P., Scherer, R. Caffeine and theobromine composition of mate (Ilex paraguariensis) leaves in five plantations of misiones, Argentina. plant foods for human nutrition, 2003, vol. 58, no. 3, p. 1–8. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
96% ethanol
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Substance:
Theobromine (RF-00000334-TOX)
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Analytical method code:
Gaschromatography (GC) (F037A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.705-1.164
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Internal remarks:
Theobromine in leaves
Composition #7: Marx, F., Janssens, M.J.J., Urfer, P., Scherer, R. Caffeine and theobromine composition of mate (Ilex paraguariensis) leaves in five plantations of misiones, Argentina. plant foods for human nutrition, 2003, vol. 58, no. 3, p. 1–8. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
96% ethanol
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Substance:
caffeine (RF-00000038-NTR)
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Analytical method code:
Gaschromatography (GC) (F037A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
1.160-1.872
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Internal remarks:
Caffeine in leaves
Composition #8: Elekofehinti, O.O. Saponins: Anti-diabetic principles from medicinal plants - A review. pathophysiology, 2015, vol. 22, no. 2, p. 95–103. DOI: 10.1016/j.pathophys.2015.02.001.
[
DOI link]
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Plant part:
Unspecified (A07XD)
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Substance:
Saponins (RF-00004333-PAR)
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Analytical method code:
Unspecified (F598A)
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Analytical method - additional description:
Reported in a review of potential therapeutic effects.
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Saponins in plant
Genotox #1: Bidau, Claudio J., Amat, Anibal G., Yajia, Malta., Marti, Dardo A., Riglos, Ana G., Silvestroni, Aurelio. Evaluation of the genotoxicity of aqueous extracts of Ilex paraguariensis St. Hil. (Aquifoliaceae) using the Allium test . cytologia (tokyo), 2004, vol. 69, no. 2, p. 109–117. DOI: 10.1508/cytologia.69.109.
[
DOI link]
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Study category:
Genotoxicity
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Type of toxicological test:
Not in the Compendium v10 (CHD058TT)
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Tested organism:
Other (A07XE)
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Endpoint measured:
chromosome aberration
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Remarks on genotox study:
Decreased mitotic index (inhibition of mitosis and chromosome abnormalities) at all concentrations tested in the allium test in vitro.
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Internal remarks:
Decreased mitotic index and chromosomal abnormalities in allium test in vitro
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Internal ID:
BCI:BCI200500019162
Genotox #2: Wnuk, Maciej., Lewinska, Anna., Oklejewicz, Bernadetta., Bugno, Monika., Slota, Ewa., Bartosz, Grzegorz. Evaluation of the cyto- and genotoxic activity of yerba mate (Ilex paraguariensis) in human lymphocytes in vitro . mutation research-genetic toxicology and environmental mutagenesis, 2009, vol. 679, no. 1-2, p. 18–23. DOI: 10.1016/j.mrgentox.2009.07.017.
[
DOI link]
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Study category:
Genotoxicity
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Type of toxicological test:
in vitro mammalian cell micronucleus test (CHD033TT)
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Tested organism:
Human (as organism) (A056J)
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Strain of test organism:
lymphocytes (CHD036ST)
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Number of organisms dosed:
1
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Endpoint measured:
DNA damage and/or repair
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Remarks on genotox study:
3.3-fold increase in micronucleus frequency in lymphocytes exposed to 10 ug/ml compared to control in "cytokinesis-block micronucleus assay."
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Internal remarks:
Increased micronucleus frequency in human lymphocytes in vitro
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Internal ID:
WOS:000272069600004
Genotox #3: Wnuk, Maciej., Lewinska, Anna., Oklejewicz, Bernadetta., Bugno, Monika., Slota, Ewa., Bartosz, Grzegorz. Evaluation of the cyto- and genotoxic activity of yerba mate (Ilex paraguariensis) in human lymphocytes in vitro . mutation research-genetic toxicology and environmental mutagenesis, 2009, vol. 679, no. 1-2, p. 18–23. DOI: 10.1016/j.mrgentox.2009.07.017.
[
DOI link]
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Study category:
Genotoxicity
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Type of toxicological test:
Not in the Compendium v10 (CHD058TT)
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Tested organism:
Human (as organism) (A056J)
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Strain of test organism:
lymphocytes (CHD036ST)
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Number of organisms dosed:
1
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Endpoint measured:
DNA damage and/or repair
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Remarks on genotox study:
3.2-3.9-fold decrease in transcriptional activity of cellular rRNA in lymphocytes exposed to 100-1000 ug/ml compared to control in "AgNOR study."
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Internal remarks:
Decreased transcriptional activity of cellular rRNA in human lymphocytes in vitro
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Internal ID:
WOS:000272069600004
Genotox #4: LEITAO, AC., BRAGA, RS. MUTAGENIC AND GENOTOXIC EFFECTS OF MATE (ILEX-PARAGUARIENSIS) IN PROKARYOTIC ORGANISMS . brazilian journal of medical and biological research, 1994, vol. 27, no. 7, p. 1517–1525. .
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Study category:
Mutagenicity
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Type of toxicological test:
bacterial gene mutation assay (CHD027TT)
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Tested organism:
Salmonella typhimurium (as organism) (A0CPZ)
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Strain of test organism:
TA 97 (CHD028ST)
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Route of exposure:
OTHER (OECD0PL)
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Control groups used:
no data
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Endpoint measured:
gene mutation
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Remarks on genotox study:
Mate aqueous solutions were introduced at the concentration of 20 to 50 mg per plate.
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Internal remarks:
Mutagenicity to Salmonella typhimurium TA97. Mate aqueous solutions were introduced at the concentration of 20 to 50 mg per plate.
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Internal ID:
WOS:A1994PA55200004
Genotox #5: LEITAO, AC., BRAGA, RS. MUTAGENIC AND GENOTOXIC EFFECTS OF MATE (ILEX-PARAGUARIENSIS) IN PROKARYOTIC ORGANISMS . brazilian journal of medical and biological research, 1994, vol. 27, no. 7, p. 1517–1525. .
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Study category:
Mutagenicity
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Type of toxicological test:
bacterial gene mutation assay (CHD027TT)
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Tested organism:
Salmonella typhimurium (as organism) (A0CPZ)
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Strain of test organism:
TA 102 (CHD025ST)
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Route of exposure:
OTHER (OECD0PL)
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Control groups used:
no data
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Endpoint measured:
gene mutation
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Remarks on genotox study:
Mate aqueous solutions were introduced at the concentration of 20 to 50 mg per plate.
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Internal remarks:
Mutagenicity to Salmonella typhimurium TA102. Mate aqueous solutions were introduced at the concentration of 20 to 50 mg per plate.
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Internal ID:
WOS:A1994PA55200004
Genotox #6: LEITAO, AC., BRAGA, RS. MUTAGENIC AND GENOTOXIC EFFECTS OF MATE (ILEX-PARAGUARIENSIS) IN PROKARYOTIC ORGANISMS . brazilian journal of medical and biological research, 1994, vol. 27, no. 7, p. 1517–1525. .
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Study category:
Mutagenicity
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Type of toxicological test:
bacterial gene mutation assay (CHD027TT)
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Tested organism:
Salmonella typhimurium (as organism) (A0CPZ)
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Strain of test organism:
TA 98 (CHD029ST)
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Route of exposure:
OTHER (OECD0PL)
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Control groups used:
no data
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Endpoint measured:
gene mutation
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Remarks on genotox study:
Mate aqueous solutions were introduced at the concentration of 20 to 50 mg per plate.
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Internal remarks:
Mutagenicity to Salmonella typhimurium TA98. Mate aqueous solutions were introduced at the concentration of 20 to 50 mg per plate.
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Internal ID:
WOS:A1994PA55200004
Genotox #7: LEITAO, AC., BRAGA, RS. MUTAGENIC AND GENOTOXIC EFFECTS OF MATE (ILEX-PARAGUARIENSIS) IN PROKARYOTIC ORGANISMS . brazilian journal of medical and biological research, 1994, vol. 27, no. 7, p. 1517–1525. .
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Study category:
Genotoxicity
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Type of toxicological test:
bacterial gene mutation assay (CHD027TT)
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Tested organism:
Escherichia coli (as organism) (A0CQA)
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Strain of test organism:
WP2 (CHD041ST)
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Route of exposure:
OTHER (OECD0PL)
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Control groups used:
no data
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Endpoint measured:
genome mutation
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Remarks on genotox study:
Mate aqueous solutions with maximal phage induction at concentrations of 10 to 20 mg/plate. Above these concentrations the mate solutions were cytotoxic
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Internal remarks:
Mate aqueous solutions with maximal phage induction at concentrations of 10 to 20 mg/plate (E. coli, WP2 lambda strain). Above these concentrations the mate solutions were cytotoxic
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Internal ID:
WOS:A1994PA55200004
Genotox #8: LEITAO, AC., BRAGA, RS. MUTAGENIC AND GENOTOXIC EFFECTS OF MATE (ILEX-PARAGUARIENSIS) IN PROKARYOTIC ORGANISMS . brazilian journal of medical and biological research, 1994, vol. 27, no. 7, p. 1517–1525. .
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Study category:
Mutagenicity
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Type of toxicological test:
bacterial gene mutation assay (CHD027TT)
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Tested organism:
Salmonella typhimurium (as organism) (A0CPZ)
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Strain of test organism:
TA 100 (CHD024ST)
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Route of exposure:
OTHER (OECD0PL)
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Control groups used:
no data
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Endpoint measured:
gene mutation
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Remarks on genotox study:
Mate aqueous solutions were introduced at the concentration of 20 to 50 mg per plate.
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Internal remarks:
Mutagenicity to Salmonella typhimurium TA100. Mate aqueous solutions were introduced at the concentration of 20 to 50 mg per plate.
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Internal ID:
WOS:A1994PA55200004