EFSA Compendium of Botanicals

Draft - work in progress

Hyssop (as plant) // Hyssopus officinalis L.

Family:: Lamiaceae (Labiatae)
Approval state:: Approved
Number of articles retrieved:: 593
Number of processed references:: 5

Compositions

Endpoint Studies

#1: Epileptic seizures in animal studies (review, no data)

Genotoxicity

Composition #1: Kotyuk, L. A. Hyssop composition depending on age and plants development phases. biotechnologia acta, 2015, vol. 8, no. 5, p. 55–63. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

iso-pinocamphone (RF-00003875-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.66-44.43
Internal remarks:

Iso-Pinocamphone in essential oil of aerial parts

Composition #2: Kotyuk, L. A. Hyssop composition depending on age and plants development phases. biotechnologia acta, 2015, vol. 8, no. 5, p. 55–63. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0-3.86
Internal remarks:

Camphor in essential oil of aerial parts

Composition #3: Kotyuk, L. A. Hyssop composition depending on age and plants development phases. biotechnologia acta, 2015, vol. 8, no. 5, p. 55–63. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

(-)-Pinocamphone (RF-00003998-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

35.49-53.73
Internal remarks:

Pinocamphone in essential oil of aerial parts

Composition #4: Kotyuk, L. A. Hyssop composition depending on age and plants development phases. biotechnologia acta, 2015, vol. 8, no. 5, p. 55–63. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

methyleugenol (RF-00003931-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.14-1.16
Internal remarks:

Methyleugenol in essential oil of aerial parts

Composition #5: Kotyuk, L. A. Hyssop composition depending on age and plants development phases. biotechnologia acta, 2015, vol. 8, no. 5, p. 55–63. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

(+)-pulegone (RF-00003398-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0-2.93
Internal remarks:

Pulegone in essential oil of aerial parts

Composition #6: Figueredo, Guilles., Ozcan, Mehmet Musa., Chalchat, Jean Claude., Bagci, Yavuz., Chalard, Pierre. Chemical Composition of Essential Oil of Hyssopus officinalis L. and Origanum acutidens . journal of essential oil bearing plants, 2012, vol. 15, no. 2, p. 300–306. DOI: 10.1080/0972060X.2012.10644051. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.92
Internal remarks:

Myrcene in essential oil of leaves

Composition #7: Figueredo, Guilles., Ozcan, Mehmet Musa., Chalchat, Jean Claude., Bagci, Yavuz., Chalard, Pierre. Chemical Composition of Essential Oil of Hyssopus officinalis L. and Origanum acutidens . journal of essential oil bearing plants, 2012, vol. 15, no. 2, p. 300–306. DOI: 10.1080/0972060X.2012.10644051. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Additional substance description:

"eucalyptol"
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.99
Internal remarks:

Eucalyptol (1,8-cineole) in essential oil of leaves

Composition #8: Figueredo, Guilles., Ozcan, Mehmet Musa., Chalchat, Jean Claude., Bagci, Yavuz., Chalard, Pierre. Chemical Composition of Essential Oil of Hyssopus officinalis L. and Origanum acutidens . journal of essential oil bearing plants, 2012, vol. 15, no. 2, p. 300–306. DOI: 10.1080/0972060X.2012.10644051. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

pinocarvone (RF-00003547-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

29.17
Internal remarks:

Pinocarvone in essential oil of leaves

Composition #9: Bajerova, Petra., Adam, Martin., Bajer, Tomas., Ventura, Karel. Comparison of various techniques for the extraction and determination of antioxidants in plants . journal of separation science, 2014, vol. 37, no. 7, p. 835–844. DOI: 10.1002/jssc.201301139. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol. Detectable amount only found in pressurized liquid extraction method, compared to several other methods in the study.
Substance:

Coumarin (RF-00000370-TOX)
Analytical method code:

HPLC-UV (F021A)
Result unit:

Microgram/100 gram (G046A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.7
Internal remarks:

Coumarin in leaves

Composition #10: Bajerova, Petra., Adam, Martin., Bajer, Tomas., Ventura, Karel. Comparison of various techniques for the extraction and determination of antioxidants in plants . journal of separation science, 2014, vol. 37, no. 7, p. 835–844. DOI: 10.1002/jssc.201301139. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol. Range of values represents differences across multiple extraction methods that were compared (supercritical fluid extraction, pressurized liquid extraction, ultrasonic extraction, soxhlet)
Substance:

Esculetin (RF-00003667-PAR)
Analytical method code:

HPLC-UV (F021A)
Result unit:

Microgram/100 gram (G046A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.9-17.6
Internal remarks:

Esculetin in leaves

Composition #11: Pandey, Vineeta., Verma, Ram S., Chauhan, Amit., Tiwari, Rakesh. Compositional variation in the leaf, flower and stem essential oils of Hyssop (Hyssopus officinalis L.) from Western-Himalaya . journal of herbal medicine, 2014, vol. 4, no. 2, p. 89–95. DOI: 10.1016/j.hermed.2013.12.001. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation. Leaves, flowers and stems analyzed separately for comparison.
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-FID (F040A)
Analytical method - additional description:

Also, GC-MS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.9-8.0
Internal remarks:

1,8-cineole in essential oil of aerial parts

Composition #12: Pandey, Vineeta., Verma, Ram S., Chauhan, Amit., Tiwari, Rakesh. Compositional variation in the leaf, flower and stem essential oils of Hyssop (Hyssopus officinalis L.) from Western-Himalaya . journal of herbal medicine, 2014, vol. 4, no. 2, p. 89–95. DOI: 10.1016/j.hermed.2013.12.001. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation. Leaves, flowers and stems analyzed separately for comparison.
Substance:

Phenanthrenes (RF-00010826-PAR)
Additional substance description:

Isopimara-9(11),15-diene
Analytical method code:

GC-FID (F040A)
Analytical method - additional description:

Also, GC-MS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<=1.9
Internal remarks:

Isopimara-9(11),15-diene (a phenanthrene) in essential oil of aerial parts

Composition #13: Pandey, Vineeta., Verma, Ram S., Chauhan, Amit., Tiwari, Rakesh. Compositional variation in the leaf, flower and stem essential oils of Hyssop (Hyssopus officinalis L.) from Western-Himalaya . journal of herbal medicine, 2014, vol. 4, no. 2, p. 89–95. DOI: 10.1016/j.hermed.2013.12.001. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation. Leaves, flowers and stems analyzed separately for comparison.
Substance:

pinocarvone (RF-00003547-PAR)
Analytical method code:

GC-FID (F040A)
Analytical method - additional description:

Also, GC-MS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.5-24.9
Internal remarks:

Pinocarvone in essential oil of aerial parts

Composition #14: Pandey, Vineeta., Verma, Ram S., Chauhan, Amit., Tiwari, Rakesh. Compositional variation in the leaf, flower and stem essential oils of Hyssop (Hyssopus officinalis L.) from Western-Himalaya . journal of herbal medicine, 2014, vol. 4, no. 2, p. 89–95. DOI: 10.1016/j.hermed.2013.12.001. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation. Leaves, flowers and stems analyzed separately for comparison.
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-FID (F040A)
Analytical method - additional description:

Also, GC-MS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.5-1.3
Internal remarks:

Myrcene in essential oil of aerial parts

Endpoint study #1: Burkhard, PR., Burkhardt, K., Haenggeli, CA., Landis, T. Plant-induced seizures: reappearance of an old problem. journal of neurology, 1999, vol. 246, no. 8, p. 667–670. DOI: 10.1007/s004150050429. [DOI link]

Study relevance:

Human health
Plant part:

Unspecified (A07XD)
Type of toxicological test:

not reported (CHD015TT)
Sex:

No data
Control groups used:

no data
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

neurologic: Brain (TT034A)
Effect description:

Eliptogenic, epileptic seizures, noted in this review article without specifics as to the in vivo studies referenced
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

Epileptic seizures in animal studies (review, no data)