EFSA Compendium of Botanicals

Draft - work in progress

Hyptis suaveolens (L.) Poit.

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 603
Number of processed references:: 11

Compositions

Endpoint Studies

Genotoxicity

Composition #1: Gottlieb, Otto R., Koketsu, Midori., Magalhaes, Mauro T., Maia, J. Guilherme S., Mendes, Paulo H., Da Rocha, A. I., Da Silva, Miriam L., Wilberg, Viktor C. Essential oils from the Amazon. VII. acta amazonica, 1981, vol. 11, no. 1, p. 143–8. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation in Clevenger apparatus
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

37
Internal remarks:

1,8-cineole

Composition #2: Kumar, S. Nandha., Thampi, Nivetha. Phytochemical screening and characterization of the bioactive compounds from the leaves of Hyptis suaveolens and Spathodea campanulata. journal of chemical and pharmaceutical research, 2015, vol. 7, no. 7, p. 840–850. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water and chloroform (separately)
Substance:

anthraquinones (RF-00004343-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Anthraquinones in leaves

Composition #3: Koche, D., Imran, S., Shirsat, R., Bhadange, D. Comparative phytochemical and nutritional studies of leaves and stem of three lamiaceae members. research journal of pharmaceutical, biological and chemical sciences, 2011, vol. 2, no. 3, p. 1–4. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

stems and leaves, extraction method unspecified
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

Quantification by methods of Harborne and Edeoga
Result unit:

Milligram/100 gram (G057A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.4-10.8
Internal remarks:

Saponins in leaves and stems

Composition #4: Koche, D., Imran, S., Shirsat, R., Bhadange, D. Comparative phytochemical and nutritional studies of leaves and stem of three lamiaceae members. research journal of pharmaceutical, biological and chemical sciences, 2011, vol. 2, no. 3, p. 1–4. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

leaves and stems, extraction method unspecified
Substance:

Cyanogenic glycosides (RF-00004375-PAR)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

Quantification by methods of Harborne and Edeoga
Result unit:

Milligram/100 gram (G057A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

41.55-50.20
Internal remarks:

Cyanogenic glycosides in leaves and stems

Composition #5: Koche, D., Shirsat, R., Imran, S., Bhadange, D.G. Phytochemical screening of eight traditionally used ethnomedicinal plants from Akola district (MS) India. international journal of pharma and bio sciences, 2010, vol. 1, no. 4 . .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

aqueous
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

Quantification of alkaloids and saponins by method of Harborne et al. 1973
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.30
Internal remarks:

Saponins in leaves

Composition #6: Koche, D., Shirsat, R., Imran, S., Bhadange, D.G. Phytochemical screening of eight traditionally used ethnomedicinal plants from Akola district (MS) India. international journal of pharma and bio sciences, 2010, vol. 1, no. 4 . .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

aqueous
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Analytical method - additional description:

Quantification of alkaloids and saponins by method of Harborne et al. 1973
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

14.30
Internal remarks:

Alkaloids in leaves

Composition #7: Shaikat, M.Z.H., Hossain, M.T., Azam, M.G. Phytochemical screening and antidiarrhoeal activity of hyptis suaveolens. international journal of applied research in natural products, 2012, vol. 5, no. 2, p. 1–4. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins in leaves

Composition #8: Shaikat, M.Z.H., Hossain, M.T., Azam, M.G. Phytochemical screening and antidiarrhoeal activity of hyptis suaveolens. international journal of applied research in natural products, 2012, vol. 5, no. 2, p. 1–4. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in leaves

Composition #9: Shaikat, M.Z.H., Hossain, M.T., Azam, M.G. Phytochemical screening and antidiarrhoeal activity of hyptis suaveolens. international journal of applied research in natural products, 2012, vol. 5, no. 2, p. 1–4. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins in leaves

Composition #10: Grassi, Paolo., Nunez, Marvin Jose., Reyes, Tomas Sigfrido Urias., Franz, Chlodwig. Chemical variation in the essential oil composition of Hyptis suaveolens (L.) Poit. (Lamiaceae) . natural product communications, 2008, vol. 3, no. 7, p. 1137–1140. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

Fenchyl alcohol (RF-00009943-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.2-8.8
Internal remarks:

Fenchol in essential oil of aerial parts

Composition #11: Grassi, Paolo., Nunez, Marvin Jose., Reyes, Tomas Sigfrido Urias., Franz, Chlodwig. Chemical variation in the essential oil composition of Hyptis suaveolens (L.) Poit. (Lamiaceae) . natural product communications, 2008, vol. 3, no. 7, p. 1137–1140. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

12.5-14.7
Internal remarks:

1,8-cineole in essential oil of aerial parts

Composition #12: Grassi, Paolo., Nunez, Marvin Jose., Reyes, Tomas Sigfrido Urias., Franz, Chlodwig. Chemical variation in the essential oil composition of Hyptis suaveolens (L.) Poit. (Lamiaceae) . natural product communications, 2008, vol. 3, no. 7, p. 1137–1140. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

fenchone (RF-00003814-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

14.0-23.4
Internal remarks:

Fenchone in essential oil of aerial parts

Composition #13: Lautie, E., Quintero, R., Fliniaux, M. -A., Villarreal, M. -L. Selection methodology with scoring system: Application to Mexican plants producing podophyllotoxin related lignans . journal of ethnopharmacology, 2008, vol. 120, no. 3, p. 402–412. DOI: 10.1016/j.jep.2008.09.014. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

podophyllotoxin (RF-00004001-PAR)
Additional substance description:

or possibly an isomer
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Podophyllotoxin in roots

Composition #14: Tripathi, Abhishek., Sharma, Neeta., Sharma, Vinay. In vitro efficacy of Hyptis suaveolens L. (Poit.) essential oil on growth and morphogenesis of Fusarium oxysporum f.sp gladioli (Massey) Snyder & Hansen . world journal of microbiology & biotechnology, 2009, vol. 25, no. 3, p. 503–512. DOI: 10.1007/s11274-008-9916-y. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Additional substance description:

beta-myrcene
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.3
Internal remarks:

Beta-Myrcene in essential oil of leaves

Composition #15: Tripathi, Abhishek., Sharma, Neeta., Sharma, Vinay. In vitro efficacy of Hyptis suaveolens L. (Poit.) essential oil on growth and morphogenesis of Fusarium oxysporum f.sp gladioli (Massey) Snyder & Hansen . world journal of microbiology & biotechnology, 2009, vol. 25, no. 3, p. 503–512. DOI: 10.1007/s11274-008-9916-y. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

44.4
Internal remarks:

1,8-cineole in essential oil of leaves

Composition #16: Tripathi, Abhishek., Sharma, Neeta., Sharma, Vinay. In vitro efficacy of Hyptis suaveolens L. (Poit.) essential oil on growth and morphogenesis of Fusarium oxysporum f.sp gladioli (Massey) Snyder & Hansen . world journal of microbiology & biotechnology, 2009, vol. 25, no. 3, p. 503–512. DOI: 10.1007/s11274-008-9916-y. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.1
Internal remarks:

Camphor in essential oil of leaves

Composition #17: Kossouoh, C., Moudachirou, M., Adjakidje, V., Chalchat, J-C., Figueredo, G. A Comparative Study of the Chemical Composition of the Leaves and Fruits Deriving the Essential Oil of Hyptis suaveolens (L.) Poit. from Benin . journal of essential oil research, 2010, vol. 22, no. 6, p. 507–509. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

Carvotanacetone (RF-00011466-PAR)
Additional substance description:

related compound: 6-hydroxycarvotanacetone
Analytical method code:

GC-FID (F040A)
Analytical method - additional description:

Also: GC-MS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.4
Internal remarks:

6-hydroxycarvotanacetone in essential oil of leaves

Composition #18: Kossouoh, C., Moudachirou, M., Adjakidje, V., Chalchat, J-C., Figueredo, G. A Comparative Study of the Chemical Composition of the Leaves and Fruits Deriving the Essential Oil of Hyptis suaveolens (L.) Poit. from Benin . journal of essential oil research, 2010, vol. 22, no. 6, p. 507–509. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

alpha-Selinene (RF-00010780-PAR)
Analytical method code:

GC-FID (F040A)
Analytical method - additional description:

Also: GC-MS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.9
Internal remarks:

alpha-selinene in essential oil of leaves

Composition #19: Kossouoh, C., Moudachirou, M., Adjakidje, V., Chalchat, J-C., Figueredo, G. A Comparative Study of the Chemical Composition of the Leaves and Fruits Deriving the Essential Oil of Hyptis suaveolens (L.) Poit. from Benin . journal of essential oil research, 2010, vol. 22, no. 6, p. 507–509. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation of fruits and leaves separately
Substance:

Diterpenes Diterpenes (RF-00004378-PAR)
Additional substance description:

isopimar-9(11),15-diene (a diterpene)
Analytical method code:

GC-FID (F040A)
Analytical method - additional description:

Also: GC-MS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.3
Internal remarks:

isopimar-9(11),15-diene (a diterpene) in essential oil of aerial parts (fruits and leaves)

Composition #20: Kossouoh, C., Moudachirou, M., Adjakidje, V., Chalchat, J-C., Figueredo, G. A Comparative Study of the Chemical Composition of the Leaves and Fruits Deriving the Essential Oil of Hyptis suaveolens (L.) Poit. from Benin . journal of essential oil research, 2010, vol. 22, no. 6, p. 507–509. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

beta-selinene (RF-00011306-PAR)
Analytical method code:

GC-FID (F040A)
Analytical method - additional description:

Also: GC-MS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.3
Internal remarks:

beta-selinene in essential oil of fruits

Composition #21: Canale, Angelo., Benelli, Giovanni., Conti, Barbara., Lenzi, Gabriele., Flamini, Guido., Francini, Alessandra., Cioni, Pier Luigi. Ingestion toxicity of three Lamiaceae essential oils incorporated in protein baits against the olive fruit fly, Bactrocera oleae (Rossi) (Diptera Tephritidae) . natural product research, 2013, vol. 27, no. 22, p. 2091–2099. DOI: 10.1080/14786419.2013.784871. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Diterpenes Diterpenes (RF-00004378-PAR)
Additional substance description:

Abietatriene, a diterpene
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

GC-EIMS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.8
Internal remarks:

Abietatriene (a diterpene) in essential oil of leaves

Composition #22: Canale, Angelo., Benelli, Giovanni., Conti, Barbara., Lenzi, Gabriele., Flamini, Guido., Francini, Alessandra., Cioni, Pier Luigi. Ingestion toxicity of three Lamiaceae essential oils incorporated in protein baits against the olive fruit fly, Bactrocera oleae (Rossi) (Diptera Tephritidae) . natural product research, 2013, vol. 27, no. 22, p. 2091–2099. DOI: 10.1080/14786419.2013.784871. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

beta-selinene (RF-00011306-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

GC-EIMS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.1
Internal remarks:

Beta-selinene in essential oil of leaves

Composition #23: Prawatsri, Saowanee., Suksamrarn, Apichart., Chindaduang, Anon., Rukachaisirikul, Thitima. Abietane Diterpenes from Hyptis suaveolens. chemistry & biodiversity, 2013, vol. 10, no. 8, p. 1494–1500. DOI: 10.1002/cbdv.201200213. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane, chloroform and methanol
Substance:

Diterpenes Diterpenes (RF-00004378-PAR)
Additional substance description:

5 abietane diterpenes: isosuaveolic acid, 8-alpha,9-alpha-epoxysuaveolic acid, 14-O-methylsuaveolic acid, suaveolic acid and suaveolol
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

Also: IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Abietane diterpenes in whole plant

Composition #24: Prawatsri, Saowanee., Suksamrarn, Apichart., Chindaduang, Anon., Rukachaisirikul, Thitima. Abietane Diterpenes from Hyptis suaveolens. chemistry & biodiversity, 2013, vol. 10, no. 8, p. 1494–1500. DOI: 10.1002/cbdv.201200213. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane, chloroform and methanol
Substance:

genistein (RF-00000297-NTR)
Additional substance description:

genistein 8-C-glucoside
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

Also: IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Genistein 8-C-glucoside in whole plant

Composition #25: Prawatsri, Saowanee., Suksamrarn, Apichart., Chindaduang, Anon., Rukachaisirikul, Thitima. Abietane Diterpenes from Hyptis suaveolens. chemistry & biodiversity, 2013, vol. 10, no. 8, p. 1494–1500. DOI: 10.1002/cbdv.201200213. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane, chloroform and methanol
Substance:

Pentacyclic triterpenic derivatives Pentacyclic triterpenic derivatives (RF-00004309-PAR)
Additional substance description:

hyptadienic acid
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

Also: IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Hyptadienic acid (a pentacyclic triterpene derivative) in whole plant

Composition #26: Prawatsri, Saowanee., Suksamrarn, Apichart., Chindaduang, Anon., Rukachaisirikul, Thitima. Abietane Diterpenes from Hyptis suaveolens. chemistry & biodiversity, 2013, vol. 10, no. 8, p. 1494–1500. DOI: 10.1002/cbdv.201200213. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane, chloroform and methanol
Substance:

Oleanolic saponins (RF-00010814-PAR)
Additional substance description:

oleanolic acid
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

Also: IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Oleanolic acid in whole plant