EFSA
ecomole
vscht
  2. Hydrastis canadensis L.

Hydrastis canadensis L.

Family:
Ranunculaceae
Approval state:
Approved
Number of articles retrieved:
636
Number of processed references:
8
Compositions
#1: Isoquinoline Alkaloids (hydrastidine, isohydrastidine​, (-​)​-​(S)​-​Corypalmine, (-​)​-​(S)​-​isocorypalmine, bis-​O,​O'-​demethyl deriv. of (-​)​-​(S)​-​tetrahydropalmatine, berberine, β-​hydrastine, canadine, and canadaline) in roots and rhizomes #2: Hydrastine (root powder) #3: Berberine (root powder) #4: Canadine (root powder) #5: Palmatine (root powder) #6: hydrastinine (root powder) #7: canadine (root powder) #8: hydrastine (root powder) #9: berberine (root powder) #10: palmatine (root powder) #11: Berberine (root powder) #12: Hydrastine (root powder) #13: Canadine (root) #14: Berberine (root) #15: Hydrastine (root) #16: Berberastine (roots) #17: Tetrahydroberberastine (roots) #18: beta-Hydrastine (roots) #19: Canadaline (roots) #20: canadine (roots) #21: berberine (roots) #22: total alkaloids (roots) #23: hydrastine (roots)
Endpoint Studies
#1: Liver weights increased, hepatocyte hypertrophy, left epidydimal weight in male mice decreased #2: Liver weights increased, hepatocyte hypertrophy, left epidydimal weight in male mice decreased #3: hepatocellular adenoma, hepatocellular carcinoma (combined), Hepatocyte degeneration and hepatocyte hypertrophy. #4: hepatocellular adenoma, hepatocellular carcinoma (combined), Hepatocyte degeneration and hepatocyte hypertrophy. #5: hepatocellular adenoma and hepatocellular adenoma or carcinoma, Eosinophilic focus, hepatocyte hypertrophy #6: hepatocellular adenoma, hepatocellular carcinoma, hepatoblastoma, eosinophilic focus #7: hepatocellular adenoma, nonneoplastic hepatic lesions, hepatocyte hypertrophy, hepatocyte degeneration, eosinophilic focus, and mixed cell focus. #8: hepatocellular adenoma, nonneoplastic hepatic lesions, hepatocyte hypertrophy, hepatocyte degeneration, eosinophilic focus, and mixed cell focus.
Genotoxicity
Composition #1: Messana, Irene., La Bua, Roberto., Galeffi, Corrado. The alkaloids of Hydrastis canadensis L. (Ranunculaceae). Two new alkaloids: hydrastidine and isohydrastidine. gazzetta chimica italiana, 1980, vol. 110(9-10), p. 539–43. .
Composition #2: Weber, HA., Zart, MK., Ferguson, SL., Greaves, JG., Clark, AP., Harris, RK., Overstreet, D., Smith, C. Separation and quantitation of isoquinoline alkaloids occurring in goldenseal . journal of liquid chromatography & related technologies, 2001, vol. 24, no. 1, p. 87–95. DOI: 10.1081/JLC-100000329. [DOI link]
Composition #3: Weber, HA., Zart, MK., Ferguson, SL., Greaves, JG., Clark, AP., Harris, RK., Overstreet, D., Smith, C. Separation and quantitation of isoquinoline alkaloids occurring in goldenseal . journal of liquid chromatography & related technologies, 2001, vol. 24, no. 1, p. 87–95. DOI: 10.1081/JLC-100000329. [DOI link]
Composition #4: Weber, HA., Zart, MK., Ferguson, SL., Greaves, JG., Clark, AP., Harris, RK., Overstreet, D., Smith, C. Separation and quantitation of isoquinoline alkaloids occurring in goldenseal . journal of liquid chromatography & related technologies, 2001, vol. 24, no. 1, p. 87–95. DOI: 10.1081/JLC-100000329. [DOI link]
Composition #5: Weber, HA., Zart, MK., Ferguson, SL., Greaves, JG., Clark, AP., Harris, RK., Overstreet, D., Smith, C. Separation and quantitation of isoquinoline alkaloids occurring in goldenseal . journal of liquid chromatography & related technologies, 2001, vol. 24, no. 1, p. 87–95. DOI: 10.1081/JLC-100000329. [DOI link]
Composition #6: Inbaraj, J. J., Kukielczak, B. M., Bilski, P., He, Y. -Y., Sik, R. H., Chignell, C. F. Photochemistry and photocytotoxicity of alkaloids from goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine . chemical research in toxicology, 2006, vol. 19, no. 6, p. 739–744. DOI: 10.1021/tx050356u. [DOI link]
Composition #7: Inbaraj, J. J., Kukielczak, B. M., Bilski, P., He, Y. -Y., Sik, R. H., Chignell, C. F. Photochemistry and photocytotoxicity of alkaloids from goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine . chemical research in toxicology, 2006, vol. 19, no. 6, p. 739–744. DOI: 10.1021/tx050356u. [DOI link]
Composition #8: Inbaraj, J. J., Kukielczak, B. M., Bilski, P., He, Y. -Y., Sik, R. H., Chignell, C. F. Photochemistry and photocytotoxicity of alkaloids from goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine . chemical research in toxicology, 2006, vol. 19, no. 6, p. 739–744. DOI: 10.1021/tx050356u. [DOI link]
Composition #9: Inbaraj, J. J., Kukielczak, B. M., Bilski, P., He, Y. -Y., Sik, R. H., Chignell, C. F. Photochemistry and photocytotoxicity of alkaloids from goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine . chemical research in toxicology, 2006, vol. 19, no. 6, p. 739–744. DOI: 10.1021/tx050356u. [DOI link]
Composition #10: Inbaraj, J. J., Kukielczak, B. M., Bilski, P., He, Y. -Y., Sik, R. H., Chignell, C. F. Photochemistry and photocytotoxicity of alkaloids from goldenseal (Hydrastis canadensis L.). 2. Palmatine, hydrastine, canadine, and hydrastinine . chemical research in toxicology, 2006, vol. 19, no. 6, p. 739–744. DOI: 10.1021/tx050356u. [DOI link]
Composition #11: Brown, Paula N., Roman, Mark C. Determination of hydrastine and berberine in goldenseal raw materials, extracts, and dietary supplements by high-performance liquid chromatography with UV: Collaborative study . journal of aoac international, 2008, vol. 91, no. 4, p. 694–701. .
Composition #12: Brown, Paula N., Roman, Mark C. Determination of hydrastine and berberine in goldenseal raw materials, extracts, and dietary supplements by high-performance liquid chromatography with UV: Collaborative study . journal of aoac international, 2008, vol. 91, no. 4, p. 694–701. .
Composition #13: Dunnick, June K., Singh, Bhanu., Nyska, Abraham., Peckham, John., Kissling, Grace E., Sanders, J. Michael. Investigating the Potential for Toxicity from Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle . toxicologic pathology, 2011, vol. 39, no. 2, p. 398–409. DOI: 10.1177/0192623310394211. [DOI link]
Composition #14: Dunnick, June K., Singh, Bhanu., Nyska, Abraham., Peckham, John., Kissling, Grace E., Sanders, J. Michael. Investigating the Potential for Toxicity from Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle . toxicologic pathology, 2011, vol. 39, no. 2, p. 398–409. DOI: 10.1177/0192623310394211. [DOI link]
Composition #15: Dunnick, June K., Singh, Bhanu., Nyska, Abraham., Peckham, John., Kissling, Grace E., Sanders, J. Michael. Investigating the Potential for Toxicity from Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle . toxicologic pathology, 2011, vol. 39, no. 2, p. 398–409. DOI: 10.1177/0192623310394211. [DOI link]
Composition #16: Avula, Bharathi., Wang, Yan-Hong., Khan, Ikhlas A. Quantitative Determination of Alkaloids from Roots of Hydrastis canadensis L. and Dietary Supplements Using Ultra-Performance Liquid Chromatography with UV Detection . journal of aoac international, 2012, vol. 95, no. 5, p. 1398–1405. DOI: 10.5740/jaoacint.12-074. [DOI link]
Composition #17: Avula, Bharathi., Wang, Yan-Hong., Khan, Ikhlas A. Quantitative Determination of Alkaloids from Roots of Hydrastis canadensis L. and Dietary Supplements Using Ultra-Performance Liquid Chromatography with UV Detection . journal of aoac international, 2012, vol. 95, no. 5, p. 1398–1405. DOI: 10.5740/jaoacint.12-074. [DOI link]
Composition #18: Avula, Bharathi., Wang, Yan-Hong., Khan, Ikhlas A. Quantitative Determination of Alkaloids from Roots of Hydrastis canadensis L. and Dietary Supplements Using Ultra-Performance Liquid Chromatography with UV Detection . journal of aoac international, 2012, vol. 95, no. 5, p. 1398–1405. DOI: 10.5740/jaoacint.12-074. [DOI link]
Composition #19: Avula, Bharathi., Wang, Yan-Hong., Khan, Ikhlas A. Quantitative Determination of Alkaloids from Roots of Hydrastis canadensis L. and Dietary Supplements Using Ultra-Performance Liquid Chromatography with UV Detection . journal of aoac international, 2012, vol. 95, no. 5, p. 1398–1405. DOI: 10.5740/jaoacint.12-074. [DOI link]
Composition #20: Dunnick, June K., Nyska, Abraham. The Toxicity and Pathology of Selected Dietary Herbal Medicines. toxicologic pathology, 2013, vol. 41, no. 2, p. 374–386. DOI: 10.1177/0192623312466451. [DOI link]
Composition #21: Dunnick, June K., Nyska, Abraham. The Toxicity and Pathology of Selected Dietary Herbal Medicines. toxicologic pathology, 2013, vol. 41, no. 2, p. 374–386. DOI: 10.1177/0192623312466451. [DOI link]
Composition #22: Dunnick, June K., Nyska, Abraham. The Toxicity and Pathology of Selected Dietary Herbal Medicines. toxicologic pathology, 2013, vol. 41, no. 2, p. 374–386. DOI: 10.1177/0192623312466451. [DOI link]
Composition #23: Dunnick, June K., Nyska, Abraham. The Toxicity and Pathology of Selected Dietary Herbal Medicines. toxicologic pathology, 2013, vol. 41, no. 2, p. 374–386. DOI: 10.1177/0192623312466451. [DOI link]
Endpoint study #1: Toxicology and carcinogenesis studies of goldenseal root powder (Hydrastis Canadensis) in F344/N rats and B6C3F1 mice (feed studies). . national toxicology program technical report series, 2010, no. 562, p. 1–188. .
Endpoint study #2: Toxicology and carcinogenesis studies of goldenseal root powder (Hydrastis Canadensis) in F344/N rats and B6C3F1 mice (feed studies). . national toxicology program technical report series, 2010, no. 562, p. 1–188. .
Endpoint study #3: Toxicology and carcinogenesis studies of goldenseal root powder (Hydrastis Canadensis) in F344/N rats and B6C3F1 mice (feed studies). . national toxicology program technical report series, 2010, no. 562, p. 1–188. .
Endpoint study #4: Toxicology and carcinogenesis studies of goldenseal root powder (Hydrastis Canadensis) in F344/N rats and B6C3F1 mice (feed studies). . national toxicology program technical report series, 2010, no. 562, p. 1–188. .
Endpoint study #5: Dunnick, June K., Singh, Bhanu., Nyska, Abraham., Peckham, John., Kissling, Grace E., Sanders, J. Michael. Investigating the Potential for Toxicity from Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle . toxicologic pathology, 2011, vol. 39, no. 2, p. 398–409. DOI: 10.1177/0192623310394211. [DOI link]
Endpoint study #6: Dunnick, June K., Singh, Bhanu., Nyska, Abraham., Peckham, John., Kissling, Grace E., Sanders, J. Michael. Investigating the Potential for Toxicity from Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle . toxicologic pathology, 2011, vol. 39, no. 2, p. 398–409. DOI: 10.1177/0192623310394211. [DOI link]
Endpoint study #7: Dunnick, June K., Nyska, Abraham. The Toxicity and Pathology of Selected Dietary Herbal Medicines. toxicologic pathology, 2013, vol. 41, no. 2, p. 374–386. DOI: 10.1177/0192623312466451. [DOI link]
Endpoint study #8: Dunnick, June K., Nyska, Abraham. The Toxicity and Pathology of Selected Dietary Herbal Medicines. toxicologic pathology, 2013, vol. 41, no. 2, p. 374–386. DOI: 10.1177/0192623312466451. [DOI link]