EFSA Compendium of Botanicals

Draft - work in progress

Hoslundia opposita Vahl

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 94
Number of processed references:: 9

Compositions

Endpoint Studies

#1: Neurological effects in mice

Genotoxicity

Composition #1: Usman, L. A., Zubair, M. F., Adebayo, S. A., Oladosu, I. A., Muhammad, N. O., Akolade, J. O. Chemical composition of leaf and fruit essential oils of Hoslundia opposita Vahl grown in Nigeria. american-eurasian journal of agricultural & environmental sciences, 2010, vol. 8, no. 1, p. 40–43. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

69.5
Internal remarks:

Camphor in essential oil of fruits

Composition #2: Usman, L. A., Zubair, M. F., Adebayo, S. A., Oladosu, I. A., Muhammad, N. O., Akolade, J. O. Chemical composition of leaf and fruit essential oils of Hoslundia opposita Vahl grown in Nigeria. american-eurasian journal of agricultural & environmental sciences, 2010, vol. 8, no. 1, p. 40–43. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

72.3
Internal remarks:

1,8-cineole in essential oil of leaves

Composition #3: Usman, L. A., Zubair, M. F., Adebayo, S. A., Oladosu, I. A., Muhammad, N. O., Akolade, J. O. Chemical composition of leaf and fruit essential oils of Hoslundia opposita Vahl grown in Nigeria. american-eurasian journal of agricultural & environmental sciences, 2010, vol. 8, no. 1, p. 40–43. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.2
Internal remarks:

1,8-cineole in essential oil of fruits

Composition #4: Akolade, J. O., Muhammad, N. O., Usman, L. A., Odebisi, M. B., Sulyman, A. O., Akanji, F. T. Effects of essential oil extracted from the leaves of Hoslundia opposita V. on selected biochemical indices in rats. british journal of pharmacology and toxicology, 2014, vol. 5, no. 3, p. 109–114. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistilled for 3 h in a Clevenger-type apparatu
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

72.3
Internal remarks:

1-8 cineole in leaf essential oil

Composition #5: Sharaibi, Olubunmi Josephine., Ogundipe, Oluwatoyin Temitayo., Afolayan, Anthony Jide., Aworinde, David Olaniran. Ethnobotanical survey and phytochemical analysis of medicinal plants used for the treatment of hyperprolactinemia in Lagos State, Nigeria. journal of medicinal plants research, 2014, vol. 8, no. 43), 1284-128, p. 5 pp. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Water and acetone
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins in plant

Composition #6: Sharaibi, Olubunmi Josephine., Ogundipe, Oluwatoyin Temitayo., Afolayan, Anthony Jide., Aworinde, David Olaniran. Ethnobotanical survey and phytochemical analysis of medicinal plants used for the treatment of hyperprolactinemia in Lagos State, Nigeria. journal of medicinal plants research, 2014, vol. 8, no. 43), 1284-128, p. 5 pp. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Water and acetone
Substance:

Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Proanthocyanidins in plant

Composition #7: Sharaibi, Olubunmi Josephine., Ogundipe, Oluwatoyin Temitayo., Afolayan, Anthony Jide., Aworinde, David Olaniran. Ethnobotanical survey and phytochemical analysis of medicinal plants used for the treatment of hyperprolactinemia in Lagos State, Nigeria. journal of medicinal plants research, 2014, vol. 8, no. 43), 1284-128, p. 5 pp. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Water and acetone
Substance:

anthraquinones (RF-00004343-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

anthraquinones in plant

Composition #8: Sharaibi, Olubunmi Josephine., Ogundipe, Oluwatoyin Temitayo., Afolayan, Anthony Jide., Aworinde, David Olaniran. Ethnobotanical survey and phytochemical analysis of medicinal plants used for the treatment of hyperprolactinemia in Lagos State, Nigeria. journal of medicinal plants research, 2014, vol. 8, no. 43), 1284-128, p. 5 pp. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Water and acetone
Substance:

cardiac glycosides (RF-00010823-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardiac glycosides in plant

Composition #9: Sharaibi, Olubunmi Josephine., Ogundipe, Oluwatoyin Temitayo., Afolayan, Anthony Jide., Aworinde, David Olaniran. Ethnobotanical survey and phytochemical analysis of medicinal plants used for the treatment of hyperprolactinemia in Lagos State, Nigeria. journal of medicinal plants research, 2014, vol. 8, no. 43), 1284-128, p. 5 pp. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Water and acetone
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins in plant

Composition #10: Ojo, O.O., Anibijuwon, I.I., Ojo, O.O. Studies on extracts of three medicinal plants of South-Western Nigeria: Hoslundia opposita, lantana camara and cymbopogon citratus. advances in natural and applied sciences, 2010, vol. 4, no. 1, p. 93–98. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

70 g dried, ground leaves soaked in 200 mL sterile distilled water
Substance:

Oxalates (RF-00004308-PAR)
Analytical method code:

Phytochemical screening (F604A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.09
Internal remarks:

Oxalates in leaves

Composition #11: Ojo, O.O., Anibijuwon, I.I., Ojo, O.O. Studies on extracts of three medicinal plants of South-Western Nigeria: Hoslundia opposita, lantana camara and cymbopogon citratus. advances in natural and applied sciences, 2010, vol. 4, no. 1, p. 93–98. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

70 g dried, ground leaves soaked in 200 mL sterile distilled water
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.27
Internal remarks:

Alkaloids in leaves

Composition #12: Ojo, O.O., Anibijuwon, I.I., Ojo, O.O. Studies on extracts of three medicinal plants of South-Western Nigeria: Hoslundia opposita, lantana camara and cymbopogon citratus. advances in natural and applied sciences, 2010, vol. 4, no. 1, p. 93–98. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

70 g dried, ground leaves soaked in 200 mL sterile distilled water
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.80
Internal remarks:

Saponins in leaves

Composition #13: Ayedoun, MA., Adeoti, BS., Setondji, J., Tchoumbougnang, F., Kuiate, JR., Zollo, PHA., Menut, C., Lamaty, G., Bessiere, JM. Aromatic plants of tropical West Africa. XII. Essential oil of Hoslundia opposita Vahl. growing in Benin and Cameroon . flavour and fragrance journal, 1999, vol. 14, no. 5, p. 319–321. DOI: 10.1002/(SICI)1099-1026(199909/10)14:5<319::AID-FFJ836>3.0.CO;2-O. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

epoxides (RF-00010829-PAR)
Additional substance description:

Caryophyllene epoxide
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.8-1.0
Internal remarks:

Caryophyllene epoxide in essential oil of leaves

Composition #14: Ayedoun, MA., Adeoti, BS., Setondji, J., Tchoumbougnang, F., Kuiate, JR., Zollo, PHA., Menut, C., Lamaty, G., Bessiere, JM. Aromatic plants of tropical West Africa. XII. Essential oil of Hoslundia opposita Vahl. growing in Benin and Cameroon . flavour and fragrance journal, 1999, vol. 14, no. 5, p. 319–321. DOI: 10.1002/(SICI)1099-1026(199909/10)14:5<319::AID-FFJ836>3.0.CO;2-O. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

(-)-globulol (RF-00003756-PAR)
Additional substance description:

"ledol"
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.6
Internal remarks:

Ledol in essential oil of leaves

Composition #15: Chagonda, LS., Chalchat, JC. The essential oil of wild and cultivated Hoslundia opposita Vahl. from Zimbabwe . flavour and fragrance journal, 2005, vol. 20, no. 2, p. 193–195. DOI: 10.1002/ffj.1402. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

55.1-76.2
Internal remarks:

Eugenol in essential oil of leaves

Composition #16: Chagonda, LS., Chalchat, JC. The essential oil of wild and cultivated Hoslundia opposita Vahl. from Zimbabwe . flavour and fragrance journal, 2005, vol. 20, no. 2, p. 193–195. DOI: 10.1002/ffj.1402. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.2-4.4
Internal remarks:

1,8-cineole in essential oil of leaves

Composition #17: Chagonda, LS., Chalchat, JC. The essential oil of wild and cultivated Hoslundia opposita Vahl. from Zimbabwe . flavour and fragrance journal, 2005, vol. 20, no. 2, p. 193–195. DOI: 10.1002/ffj.1402. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.5-1.0
Internal remarks:

Camphor in essential oil of leaves

Composition #18: Tonzibo, Z. F., Coffy, A. Ahibo., Chalachat, J. C., N'guessan, Y. T. Chemical composition of essential oils of Hoslundia opposita Vahl. from Ivory Coast. . flavour and fragrance journal, 2006, vol. 21, no. 5, p. 789–791. DOI: 10.1002/ffj.1715. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-FID-MS (F607A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.3-2.4
Internal remarks:

1,8-cineole in essential oil of leaves

Composition #19: Tonzibo, Z. F., Coffy, A. Ahibo., Chalachat, J. C., N'guessan, Y. T. Chemical composition of essential oils of Hoslundia opposita Vahl. from Ivory Coast. . flavour and fragrance journal, 2006, vol. 21, no. 5, p. 789–791. DOI: 10.1002/ffj.1715. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

menthofuran (RF-00003924-PAR)
Analytical method code:

GC-FID-MS (F607A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.6-3.9
Internal remarks:

Menthofuran in essential oil of leaves

Composition #20: Tonzibo, Z. F., Coffy, A. Ahibo., Chalachat, J. C., N'guessan, Y. T. Chemical composition of essential oils of Hoslundia opposita Vahl. from Ivory Coast. . flavour and fragrance journal, 2006, vol. 21, no. 5, p. 789–791. DOI: 10.1002/ffj.1715. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

Diterpenes Diterpenes (RF-00004378-PAR)
Additional substance description:

Phytol
Analytical method code:

GC-FID-MS (F607A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.3-5.9
Internal remarks:

Phytol diterpene in essential oil of leaves

Composition #21: Tonzibo, Z. F., Coffy, A. Ahibo., Chalachat, J. C., N'guessan, Y. T. Chemical composition of essential oils of Hoslundia opposita Vahl. from Ivory Coast. . flavour and fragrance journal, 2006, vol. 21, no. 5, p. 789–791. DOI: 10.1002/ffj.1715. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

menthone (RF-00011280-PAR)
Analytical method code:

GC-FID-MS (F607A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.6-7
Internal remarks:

Menthone in essential oil of leaves

Composition #22: Tonzibo, Z. F., Coffy, A. Ahibo., Chalachat, J. C., N'guessan, Y. T. Chemical composition of essential oils of Hoslundia opposita Vahl. from Ivory Coast. . flavour and fragrance journal, 2006, vol. 21, no. 5, p. 789–791. DOI: 10.1002/ffj.1715. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

(+)-pulegone (RF-00003398-PAR)
Analytical method code:

GC-FID-MS (F607A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.4-1.3
Internal remarks:

Pulegone in essential oil of leaves

Composition #23: Mujovo, Silva F., Hussein, Ahmed A., Meyer, J. J. Marion., Fourie, B., Muthivhi, Tshilidzi., Lall, Namrita. Bioactive compounds from Lippia javanica and Hoslundia opposita. natural product research, 2008, vol. 22, no. 12, p. 1047–1054. DOI: 10.1080/14786410802250037. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

130 g extracted with 1.5 L ethanol
Substance:

Pentacyclic triterpenic derivatives Pentacyclic triterpenic derivatives (RF-00004309-PAR)
Additional substance description:

Euscaphic acid
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Milligram (G155A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

80
Internal remarks:

Euscaphic acid (a pentacyclic triterpene) in leaves

Endpoint study #1: Olajide, OA., Awe, SO., Makinde, JM. Central nervous system depressant effect of Hoslundia opposita Vahl. phytotherapy research, 1999, vol. 13, no. 5, p. 425–426. DOI: 10.1002/(SICI)1099-1573(199908/09)13:5<425::AID-PTR466>3.3.CO;2-T. [DOI link]

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

chloroform
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

Swiss (CHD005ST)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Number of organisms dosed:

5
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight (G225A)
Effect concentration:

50-100
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

neurologic: Central Nervous System (TT035A)
Effect description:

Extract produced loss of both cornea and pinna reflexes, a decrease in locomotor activity and mild sedation in mice.
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

Neurological effects in mice