EFSA
ecomole
vscht
  2. Smooth rupturewort (as plant) // Herniaria glabra L.

Smooth rupturewort (as plant) // Herniaria glabra L.

Family:
Caryophyllaceae
Approval state:
Approved
Number of articles retrieved:
99
Number of processed references:
5
Compositions
#1: Dillapiol in essential oil #2: Estragol in essential oil #3: triterpene saponins #4: Herniaria Saponin 3 (a pentacyclic triterpene saponin) in aerial parts #5: Triterpene saponins in aerial parts
Endpoint Studies
#1: 90-day study in rats: Decreased body weight gain at 1 g/kg bw/day. Histopathological changes in liver and kidney at 4 g/kg bw/day.
Genotoxicity
Composition #1: Hethelyi, E. B., Galambosi, B., Szarka, S., Lemberkovics, E., Szoke, E. Phytochemical investigation of medicinal and culinary herbs. acta agronomica hungarica, 2012, vol. 60, no. 3, p. 201–207. .
Composition #2: Hethelyi, E. B., Galambosi, B., Szarka, S., Lemberkovics, E., Szoke, E. Phytochemical investigation of medicinal and culinary herbs. acta agronomica hungarica, 2012, vol. 60, no. 3, p. 201–207. .
Composition #3: Khakim, El Mabruki., Klemper, A. V., Kaukhova, I. E., Sorokin, V. V. ESTABLISHMENT OF RUPTUREWORT (HERNIARIA GIABRA) HERB IDENTITY CHARACTERESTICS AND QUALITY INDICES . farmatsiya (moscow), 2014, no. 6, p. 21–24. .
Composition #4: SCHRODER, H., SCHUBERTZSILAVECZ, M., REZNICEK, G., CART, J., JURENITSCH, J., HASLINGER, E. A TRITERPENE SAPONIN FROM HERNIARIA-GLABRA. phytochemistry, 1993, vol. 34, no. 6, p. 1609–1613. DOI: 10.1016/S0031-9422(00)90855-0. [DOI link]
Composition #5: Freiler, M., Reznicek, G., Jorenitsch, J., Kubelka, W., Schmidt, W., SchubertZsilavecz, M., Haslinger, E., Reiner, J. New triterpene saponins from Herniaria glabra. helvetica chimica acta, 1996, vol. 79, no. 2, p. 385–390. DOI: 10.1002/hlca.19960790207. [DOI link]
Endpoint study #1: Rhiouani, Hamid., El-Hilaly, Jaouad., Israili, Zafar H., Lyoussi, Badiaa. Acute and sub-chronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents . journal of ethnopharmacology, 2008, vol. 118, no. 3, p. 378–386. DOI: 10.1016/j.jep.2008.05.009. [DOI link]