EFSA Compendium of Botanicals

Draft - work in progress

Heracleum mantegazzianum Sommier & Levier

Family:: Apiaceae
Approval state:: Approved
Number of articles retrieved:: 397
Number of processed references:: 4

Compositions

#1: isopimpinellin (fruit) #2: Bergapten (fruit) #3: imperatorin (fruit) #4: xanthotoxin (fruit) #5: pimpinellin (fruit) #6: limettin (fruit) #7: 5-methoxy-7-(3,3-dimethylalliloxy)-coumarin (fruit) #8: coumarins in essential oil from seeds #9: furanocoumarins in essential oil from seeds #10: Phellopterin (fruit) #11: Angelicin (fruit) #12: psoralens in all part of the plant (highest levels in leaves)

Endpoint Studies

Genotoxicity

Composition #1: Glowniak, K., Mroczek, T., Zabza, A., Cierpicki, T. Isolation and structure elucidation of 5,7-disubstituted simple coumarins in the fruits of Heracleum mantegazzianum . pharmaceutical biology, 2000, vol. 38, no. 4, p. 308–312. DOI: 10.1076/1388-0209(200009)3841-AFT308. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petroleum Ether
Substance:

Isopimpinellin (RF-00003784-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

TLC, HPLC, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

isopimpinellin (fruit)

Composition #2: Glowniak, K., Mroczek, T., Zabza, A., Cierpicki, T. Isolation and structure elucidation of 5,7-disubstituted simple coumarins in the fruits of Heracleum mantegazzianum . pharmaceutical biology, 2000, vol. 38, no. 4, p. 308–312. DOI: 10.1076/1388-0209(200009)3841-AFT308. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petroleum Ether
Substance:

Bergapten (RF-00003837-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

TLC, HPLC, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Bergapten (fruit)

Composition #3: Glowniak, K., Mroczek, T., Zabza, A., Cierpicki, T. Isolation and structure elucidation of 5,7-disubstituted simple coumarins in the fruits of Heracleum mantegazzianum . pharmaceutical biology, 2000, vol. 38, no. 4, p. 308–312. DOI: 10.1076/1388-0209(200009)3841-AFT308. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petroleum Ether
Substance:

imperatorin (RF-00003874-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

TLC, HPLC, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

imperatorin (fruit)

Composition #4: Glowniak, K., Mroczek, T., Zabza, A., Cierpicki, T. Isolation and structure elucidation of 5,7-disubstituted simple coumarins in the fruits of Heracleum mantegazzianum . pharmaceutical biology, 2000, vol. 38, no. 4, p. 308–312. DOI: 10.1076/1388-0209(200009)3841-AFT308. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petroleum Ether
Substance:

Methoxsalen Methoxsalen (RF-00003863-PAR)
Additional substance description:

xanthotoxin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

TLC, HPLC, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

xanthotoxin (fruit)

Composition #5: Glowniak, K., Mroczek, T., Zabza, A., Cierpicki, T. Isolation and structure elucidation of 5,7-disubstituted simple coumarins in the fruits of Heracleum mantegazzianum . pharmaceutical biology, 2000, vol. 38, no. 4, p. 308–312. DOI: 10.1076/1388-0209(200009)3841-AFT308. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petroleum Ether
Substance:

pimpinellin (RF-00003997-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

TLC, HPLC, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

pimpinellin (fruit)

Composition #6: Glowniak, K., Mroczek, T., Zabza, A., Cierpicki, T. Isolation and structure elucidation of 5,7-disubstituted simple coumarins in the fruits of Heracleum mantegazzianum . pharmaceutical biology, 2000, vol. 38, no. 4, p. 308–312. DOI: 10.1076/1388-0209(200009)3841-AFT308. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petroleum Ether
Substance:

limettin (RF-00011371-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

TLC, HPLC, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

limettin (fruit)

Composition #7: Glowniak, K., Mroczek, T., Zabza, A., Cierpicki, T. Isolation and structure elucidation of 5,7-disubstituted simple coumarins in the fruits of Heracleum mantegazzianum . pharmaceutical biology, 2000, vol. 38, no. 4, p. 308–312. DOI: 10.1076/1388-0209(200009)3841-AFT308. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Petroleum Ether
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

5-methoxy-7-(3,3-dimethylalliloxy)-coumarin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

TLC, HPLC, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

5-methoxy-7-(3,3-dimethylalliloxy)-coumarin (fruit)

Composition #8: Jakubska-Busse, A., Sliwinski, M., Kobylka, M. IDENTIFICATION OF BIOACTIVE COMPONENTS OF ESSENTIAL OILS IN HERACLEUM SOSNOWSKYI AND HERACLEUM MANTEGAZZIANUM (APIACEAE) . archives of biological sciences, 2013, vol. 65, no. 3, p. 877–883. DOI: 10.2298/ABS1303877J. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

One seed sample weighing 25.0 g was extracted with 50 ml of n-pentane in an airtight glass container with a teflon gasket. Another 25.0 g seed sample was extracted with 50 ml of dichloromethane
Substance:

coumarins (RF-00004351-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

coumarins in essential oil from seeds

Composition #9: Jakubska-Busse, A., Sliwinski, M., Kobylka, M. IDENTIFICATION OF BIOACTIVE COMPONENTS OF ESSENTIAL OILS IN HERACLEUM SOSNOWSKYI AND HERACLEUM MANTEGAZZIANUM (APIACEAE) . archives of biological sciences, 2013, vol. 65, no. 3, p. 877–883. DOI: 10.2298/ABS1303877J. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

One seed sample weighing 25.0 g was extracted with 50 ml of n-pentane in an airtight glass container with a teflon gasket. Another 25.0 g seed sample was extracted with 50 ml of dichloromethane
Substance:

Furanocoumarins (RF-00004381-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

furanocoumarins in essential oil from seeds

Composition #10: Walasek, Magdalena., Grzegorczyk, Agnieszka., Malm, Anna., Skalicka-Wozniak, Krystyna. Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography . food chemistry, 2015, vol. 186, p. 133–138. DOI: 10.1016/j.foodchem.2015.02.011. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichloromethane
Substance:

Phellopterin (RF-00003560-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC, HPCCC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Phellopterin (fruit)

Composition #11: Walasek, Magdalena., Grzegorczyk, Agnieszka., Malm, Anna., Skalicka-Wozniak, Krystyna. Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography . food chemistry, 2015, vol. 186, p. 133–138. DOI: 10.1016/j.foodchem.2015.02.011. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dichloromethane
Substance:

angelicin (RF-00004146-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC, HPCCC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Angelicin (fruit)

Composition #12: KNUDSEN, EA. SEASONAL-VARIATIONS IN THE CONTENT OF PHOTO-TOXIC COMPOUNDS IN GIANT HOGWEED . contact dermatitis, 1983, vol. 9, no. 4, p. 281–284. DOI: 10.1111/j.1600-0536.1983.tb04391.x. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

psoralen (RF-00004015-PAR)
Additional substance description:

8-methoxypsoralen
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

psoralens in all part of the plant (highest levels in leaves)