EFSA
ecomole
vscht
  2. Heliotropium indicum L.

Heliotropium indicum L.

Family:
Boraginaceae
Approval state:
Approved
Number of articles retrieved:
335
Number of processed references:
11
Compositions
#1: Saponins in leaves #2: Alkaloids in leaves. #3: Tannins in leaves #4: Pyrrolizidine alkaloids in aerial parts #5: Tannins the aerial parts #6: Saponins in aerial parts #7: Tannins #8: Alkaloids #9: Saponins #10: Indicine in flowers #11: Lycosamine in flowers. #12: Indicine N-oxide in flowers. #13: Lycopsamine-N-oxide in flowers. #14: Echinatine-N-oxide in flowers. #15: Intemedine in flowers. #16: Intermedine-N-oxide in flowers. #17: Echinatine in flowers. #18: Pyrrolizidine alkaloids in bud (total). #19: Pyrrolizidine alkaloids in flowers (total) #20: Pyrrolizidine alkaloids in fruit (total) #21: Pyrrolizidine alkaloids in stem (total) #22: Pyrrolizidine alkaloids in leaves. #23: Pyrrolizidine alkaloids in roots (total). #24: Isoquinoline alkaloids (2-ethyl-1,2,3,4-tetrahydro-6-hydroxymethyl isoquinoline) in leaves #25: Pyrrolizidine alkaloid (Heliotrine, Lasiocarpine)
Endpoint Studies
#1: Hepatotoxicity and liver tumours in rats. #2: Histopathological changes in liver, kidneys and spleen #3: LD50 of the extract given orally to mice #4: 5 months exposure of ethanol extract of leaves (2 g/kg bw/day) caused reduction in sperm cell number and inflammatory changes on rat testes. #5: Chronic probable poisoning by pyrrolizidine alkaloids in H. indica through pasture. #6: Histopathologic changes in liver, lung, heart and kidneys of rats. #7: LD50 in mice according to the OECD423 (2001) guideline.
Genotoxicity
Composition #1: Afolabi, F., Afolabi, O. J. Phytochemical constituents of some medicinal plants in South West, Nigeria. iosr journal of applied chemistry, 2013, vol. 4, no. 1), 76-7, p. 3 pp. .
Composition #2: Afolabi, F., Afolabi, O. J. Phytochemical constituents of some medicinal plants in South West, Nigeria. iosr journal of applied chemistry, 2013, vol. 4, no. 1), 76-7, p. 3 pp. .
Composition #3: Afolabi, F., Afolabi, O. J. Phytochemical constituents of some medicinal plants in South West, Nigeria. iosr journal of applied chemistry, 2013, vol. 4, no. 1), 76-7, p. 3 pp. .
Composition #4: Biradi, Mahesh., Hullatti, Kirankumar. Screening of Indian medicinal plants for cytotoxic activity by brine shrimp lethality (BSL) assay and evaluation of their total phenolic content. drug development and therapeutics, 2014, vol. 5, no. 2, p. 139–144. .
Composition #5: Biradi, Mahesh., Hullatti, Kirankumar. Screening of Indian medicinal plants for cytotoxic activity by brine shrimp lethality (BSL) assay and evaluation of their total phenolic content. drug development and therapeutics, 2014, vol. 5, no. 2, p. 139–144. .
Composition #6: Biradi, Mahesh., Hullatti, Kirankumar. Screening of Indian medicinal plants for cytotoxic activity by brine shrimp lethality (BSL) assay and evaluation of their total phenolic content. drug development and therapeutics, 2014, vol. 5, no. 2, p. 139–144. .
Composition #7: Kyei, S., Koffuor, G.A., Ramkissoon, P., Asante, D.-B. Oral and ocular safety profile of whole plant aqueous extract of Heliotropium indicum L. In rodents. research journal of medicinal plant, 2015, vol. 9, no. 7, p. 321–330. DOI: 10.3923/rjmp.2015.321.330. [DOI link]
Composition #8: Kyei, S., Koffuor, G.A., Ramkissoon, P., Asante, D.-B. Oral and ocular safety profile of whole plant aqueous extract of Heliotropium indicum L. In rodents. research journal of medicinal plant, 2015, vol. 9, no. 7, p. 321–330. DOI: 10.3923/rjmp.2015.321.330. [DOI link]
Composition #9: Kyei, S., Koffuor, G.A., Ramkissoon, P., Asante, D.-B. Oral and ocular safety profile of whole plant aqueous extract of Heliotropium indicum L. In rodents. research journal of medicinal plant, 2015, vol. 9, no. 7, p. 321–330. DOI: 10.3923/rjmp.2015.321.330. [DOI link]
Composition #10: van de Schans, M.G.M., Blokland, M.H., Zoontjes, P.W., Mulder, P.P.J., Nielen, M.W.F. Multiple heart-cutting two dimensional liquid chromatography quadrupole time-of-flight mass spectrometry of pyrrolizidine alkaloids. journal of chromatography a, 2017, vol. 1503, p. 38–48. DOI: 10.1016/j.chroma.2017.04.059. [DOI link]
Composition #11: van de Schans, M.G.M., Blokland, M.H., Zoontjes, P.W., Mulder, P.P.J., Nielen, M.W.F. Multiple heart-cutting two dimensional liquid chromatography quadrupole time-of-flight mass spectrometry of pyrrolizidine alkaloids. journal of chromatography a, 2017, vol. 1503, p. 38–48. DOI: 10.1016/j.chroma.2017.04.059. [DOI link]
Composition #12: van de Schans, M.G.M., Blokland, M.H., Zoontjes, P.W., Mulder, P.P.J., Nielen, M.W.F. Multiple heart-cutting two dimensional liquid chromatography quadrupole time-of-flight mass spectrometry of pyrrolizidine alkaloids. journal of chromatography a, 2017, vol. 1503, p. 38–48. DOI: 10.1016/j.chroma.2017.04.059. [DOI link]
Composition #13: van de Schans, M.G.M., Blokland, M.H., Zoontjes, P.W., Mulder, P.P.J., Nielen, M.W.F. Multiple heart-cutting two dimensional liquid chromatography quadrupole time-of-flight mass spectrometry of pyrrolizidine alkaloids. journal of chromatography a, 2017, vol. 1503, p. 38–48. DOI: 10.1016/j.chroma.2017.04.059. [DOI link]
Composition #14: van de Schans, M.G.M., Blokland, M.H., Zoontjes, P.W., Mulder, P.P.J., Nielen, M.W.F. Multiple heart-cutting two dimensional liquid chromatography quadrupole time-of-flight mass spectrometry of pyrrolizidine alkaloids. journal of chromatography a, 2017, vol. 1503, p. 38–48. DOI: 10.1016/j.chroma.2017.04.059. [DOI link]
Composition #15: van de Schans, M.G.M., Blokland, M.H., Zoontjes, P.W., Mulder, P.P.J., Nielen, M.W.F. Multiple heart-cutting two dimensional liquid chromatography quadrupole time-of-flight mass spectrometry of pyrrolizidine alkaloids. journal of chromatography a, 2017, vol. 1503, p. 38–48. DOI: 10.1016/j.chroma.2017.04.059. [DOI link]
Composition #16: van de Schans, M.G.M., Blokland, M.H., Zoontjes, P.W., Mulder, P.P.J., Nielen, M.W.F. Multiple heart-cutting two dimensional liquid chromatography quadrupole time-of-flight mass spectrometry of pyrrolizidine alkaloids. journal of chromatography a, 2017, vol. 1503, p. 38–48. DOI: 10.1016/j.chroma.2017.04.059. [DOI link]
Composition #17: van de Schans, M.G.M., Blokland, M.H., Zoontjes, P.W., Mulder, P.P.J., Nielen, M.W.F. Multiple heart-cutting two dimensional liquid chromatography quadrupole time-of-flight mass spectrometry of pyrrolizidine alkaloids. journal of chromatography a, 2017, vol. 1503, p. 38–48. DOI: 10.1016/j.chroma.2017.04.059. [DOI link]
Composition #18: Froelich, Cordula., Ober, Dietrich., Hartmann, Thomas. Tissue distribution, core blosynthesis and diversification of pyrrolizidine alkaloids of the lycopsamine type in three Boraginaceae species . phytochemistry, 2007, vol. 68, no. 7, p. 1026–1037. DOI: 10.1016/j.phytochem.2007.01.002. [DOI link]
Composition #19: Froelich, Cordula., Ober, Dietrich., Hartmann, Thomas. Tissue distribution, core blosynthesis and diversification of pyrrolizidine alkaloids of the lycopsamine type in three Boraginaceae species . phytochemistry, 2007, vol. 68, no. 7, p. 1026–1037. DOI: 10.1016/j.phytochem.2007.01.002. [DOI link]
Composition #20: Froelich, Cordula., Ober, Dietrich., Hartmann, Thomas. Tissue distribution, core blosynthesis and diversification of pyrrolizidine alkaloids of the lycopsamine type in three Boraginaceae species . phytochemistry, 2007, vol. 68, no. 7, p. 1026–1037. DOI: 10.1016/j.phytochem.2007.01.002. [DOI link]
Composition #21: Froelich, Cordula., Ober, Dietrich., Hartmann, Thomas. Tissue distribution, core blosynthesis and diversification of pyrrolizidine alkaloids of the lycopsamine type in three Boraginaceae species . phytochemistry, 2007, vol. 68, no. 7, p. 1026–1037. DOI: 10.1016/j.phytochem.2007.01.002. [DOI link]
Composition #22: Froelich, Cordula., Ober, Dietrich., Hartmann, Thomas. Tissue distribution, core blosynthesis and diversification of pyrrolizidine alkaloids of the lycopsamine type in three Boraginaceae species . phytochemistry, 2007, vol. 68, no. 7, p. 1026–1037. DOI: 10.1016/j.phytochem.2007.01.002. [DOI link]
Composition #23: Froelich, Cordula., Ober, Dietrich., Hartmann, Thomas. Tissue distribution, core blosynthesis and diversification of pyrrolizidine alkaloids of the lycopsamine type in three Boraginaceae species . phytochemistry, 2007, vol. 68, no. 7, p. 1026–1037. DOI: 10.1016/j.phytochem.2007.01.002. [DOI link]
Composition #24: Dolui, A. K., Debnath, Manabendra., De, B., Kumar, Atul. Reproductive activities of Heliotropium indicum isolate against Helopeltis theivora and toxicity evaluation in mice . journal of environmental biology, 2012, vol. 33, no. 3, p. 603–607. .
Composition #25: Zhou, Jue., Ouedraogo, Moustapha., Qu, Fan., Duez, Pierre. Potential Genotoxicity of Traditional Chinese Medicinal Plants and Phytochemicals: An Overview . phytotherapy research, 2013, vol. 27, no. 12, p. 1745–1755. DOI: 10.1002/ptr.4942. [DOI link]
Endpoint study #1: Schoental, Regina. Toxicology and carcinogenic action of pyrrolizidine alkaloids. cancer research, 1968, vol. 28, no. 11, p. 2237–46. .
Endpoint study #2: Kyei, S., Koffuor, G.A., Ramkissoon, P., Asante, D.-B. Oral and ocular safety profile of whole plant aqueous extract of Heliotropium indicum L. In rodents. research journal of medicinal plant, 2015, vol. 9, no. 7, p. 321–330. DOI: 10.3923/rjmp.2015.321.330. [DOI link]
Endpoint study #3: Owolabi, M A., Oribayo, O O., Ukpo, G E., Mbaka, G O., Akindehin, O E. A 5-month toxicity study of the ethanol extract of the leaves of Heliotropium indicum in Sprague Dawley rats after oral administration. . nigerian quarterly journal of hospital medicine, 2015, vol. 25, no. 3, p. 184–92. .
Endpoint study #4: Owolabi, M A., Oribayo, O O., Ukpo, G E., Mbaka, G O., Akindehin, O E. A 5-month toxicity study of the ethanol extract of the leaves of Heliotropium indicum in Sprague Dawley rats after oral administration. . nigerian quarterly journal of hospital medicine, 2015, vol. 25, no. 3, p. 184–92. .
Endpoint study #5: van Weeren, PR., Morales, JA., Rodriguez, LL., Cedeno, H., Villalobos, J., Poveda, LJ. Mortality supposedly due to intoxication by pyrrolizidine alkaloids from Heliotropium indicum in a horse population in Costa Rica: A case report . veterinary quarterly, 1999, vol. 21, no. 2, p. 59–62. .
Endpoint study #6: Boye, A., Koffuor, G. A., Amoateng, P., Ameyaw, E. O., Abaitey, A. K. Analgesic Activity and Safety Assessment of Heliotropium indicum Linn. (Boraginaceae) in Rodents . international journal of pharmacology, 2012, vol. 8, no. 2, p. 91–100. DOI: 10.3923/ijp.2012.91.100. [DOI link]
Endpoint study #7: Dolui, A. K., Debnath, Manabendra., De, B., Kumar, Atul. Reproductive activities of Heliotropium indicum isolate against Helopeltis theivora and toxicity evaluation in mice . journal of environmental biology, 2012, vol. 33, no. 3, p. 603–607. .