EFSA Compendium of Botanicals

Draft - work in progress

Curry herb (as plant) // Helichrysum italicum (Roth) G.Don // Helichrysum italicum subsp. italicum

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 323
Number of processed references:: 7

Compositions

#1: isoscopoletin in flowers #2: esculetin in flowers #3: scopoletin in flowers #4: 1,8-cineole in essential oil #5: iso-Italicene epoxide in essential oil from aerial parts #6: neolignans in leaves #7: Benzofurans (12-acetoxytremetone and 2,3-dihydro-2-[1-(hydroxymethyl)ethenyl]-5-benzofuranyl]- ethanone) in flowers #8: Various benzofuran derivatives present in the flower

Endpoint Studies

#1: alpha-glucosidase inhibition #2: alpha-amylase inhibition

Genotoxicity

Composition #1: Karasartov, B. S., Kurkin, V. A., Zapesochnaya, G. G. Coumarins and flavonoids of the flowers of Helichrysum italicum. khimiya prirodnykh soedinenii, 1992, vol. (5), p. 577–579. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

Isoscopoletin (RF-00010985-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Analytical method - additional description:

silica gel chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

isoscopoletin in flowers

Composition #2: Karasartov, B. S., Kurkin, V. A., Zapesochnaya, G. G. Coumarins and flavonoids of the flowers of Helichrysum italicum. khimiya prirodnykh soedinenii, 1992, vol. (5), p. 577–579. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

Esculetin (RF-00003667-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Analytical method - additional description:

silica gel chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

esculetin in flowers

Composition #3: Karasartov, B. S., Kurkin, V. A., Zapesochnaya, G. G. Coumarins and flavonoids of the flowers of Helichrysum italicum. khimiya prirodnykh soedinenii, 1992, vol. (5), p. 577–579. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

scopoletin (RF-00004048-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Analytical method - additional description:

silica gel chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

scopoletin in flowers

Composition #4: Bianchini, A., Tomi, P., Costa, J., Bernardini, AF. Composition of Helichrysum italicum (Roth) G. Don fil. subsp italicum essential oils from Corsica (France) . flavour and fragrance journal, 2001, vol. 16, no. 1, p. 30–34. DOI: 10.1002/1099-1026(200101/02)16:1<30::AID-FFJ941>3.0.CO;2-F. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Percent (G138A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<=1.4
Internal remarks:

1,8-cineole in essential oil

Composition #5: Mancini, Emilia., De Martino, Laura., Marandino, Aurelio., Scognamiglio, Maria Rosa., De Feo, Vincenzo. Chemical Composition and Possible in Vitro Phytotoxic Activity of Helichrsyum italicum (Roth) Don ssp. italicum . molecules, 2011, vol. 16, no. 9, p. 7725–7735. DOI: 10.3390/molecules16097725. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

epoxides (RF-00010829-PAR)
Additional substance description:

iso-Italicene epoxide
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

16.8
Internal remarks:

iso-Italicene epoxide in essential oil from aerial parts

Composition #6: D'Abrosca, Brigida., Buommino, Elisabetta., D'Angelo, Grazia., Coretti, Lorena., Scognamiglio, Monica., Severino, Valeria., Pacifico, Severina., Donnarumma, Giovanna., Fiorentino, Antonio. Spectroscopic identification and anti-biofilm properties of polar metabolites from the medicinal plant Helichrysum italicum against Pseudomonas aeruginosa . bioorganic & medicinal chemistry, 2013, vol. 21, no. 22, p. 7038–7046. DOI: 10.1016/j.bmc.2013.09.019. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

neolignans (RF-00004386-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

UV, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

neolignans in leaves

Composition #7: Rigano, Daniela., Formisano, Carmen., Senatore, Felice., Piacente, Sonia., Pagano, Ester., Capasso, Raffaele., Borrelli, Francesca., Izzo, Angelo A. Intestinal antispasmodic effects of Helichrysum italicum (Roth) Don ssp italicum and chemical identification of the active ingredients . journal of ethnopharmacology, 2013, vol. 150, no. 3, p. 901–906. DOI: 10.1016/j.jep.2013.09.034. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Benzofurans (RF-00010791-PAR)
Additional substance description:

12-acetoxytremetone and 2,3-dihydro-2-[1-(hydroxymethyl)ethenyl]-5-benzofuranyl]- ethanone
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

TLC, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Benzofurans (12-acetoxytremetone and 2,3-dihydro-2-[1-(hydroxymethyl)ethenyl]-5-benzofuranyl]- ethanone) in flowers

Composition #8: Jerkovic, Igor., Rajic, Marina., Marijanovic, Zvonimir., Bilic, Mate., Jokic, Stela. Optimization of supercritical CO2 extraction of dried Helichrysum italicum flowers by response surface methodology: GC-MS profiles of the extracts and essential oil . separation science and technology, 2016, vol. 51, no. 18, p. 2925–2931. DOI: 10.1080/01496395.2016.1237967. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Additional extraction description:

hydrodistillation or supercritical CO2 extraction
Substance:

Benzofurans (RF-00010791-PAR)
Additional substance description:

12-Acetoxytremetone, 1-[2-(2-Methyl-2,3-dihydroxypropyl)-2,3-dihydro-1-benzofuran-5-yl] ethanone and Gnaphalio
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

< 25
Internal remarks:

Various benzofuran derivatives present in the flower

Endpoint study #1: Laura de la Garza, Ana., Etxeberria, Usune., Pilar Lostao, Maria., San Roman, Belen., Barrenetxe, Jaione., Alfredo Martinez, J., Milagro, Fermin I. Helichrysum and Grapefruit Extracts Inhibit Carbohydrate Digestion and Absorption, Improving Postprandial Glucose Levels and Hyperinsulinemia in Rats . journal of agricultural and food chemistry, 2013, vol. 61, no. 49, p. 12012–12019. DOI: 10.1021/jf4021569. [DOI link]

Study relevance:

Human health
Plant part:

Live plants (as part-nature) (A0BA0)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanol/water
Type of toxicological test:

in vitro (CHD061TT)
Control groups used:

no data
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Milligram/100 Millilitre (G058A)
Effect concentration:

0.19
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alpha-glucosidase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-glucosidase inhibition

Endpoint study #2: Laura de la Garza, Ana., Etxeberria, Usune., Pilar Lostao, Maria., San Roman, Belen., Barrenetxe, Jaione., Alfredo Martinez, J., Milagro, Fermin I. Helichrysum and Grapefruit Extracts Inhibit Carbohydrate Digestion and Absorption, Improving Postprandial Glucose Levels and Hyperinsulinemia in Rats . journal of agricultural and food chemistry, 2013, vol. 61, no. 49, p. 12012–12019. DOI: 10.1021/jf4021569. [DOI link]

Study relevance:

Human health
Plant part:

Live plants (as part-nature) (A0BA0)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanol/water
Type of toxicological test:

in vitro (CHD061TT)
Control groups used:

no data
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Milligram/100 Millilitre (G058A)
Effect concentration:

0.83
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alpha-amylase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-amylase inhibition