EFSA Compendium of Botanicals

Draft - work in progress

Hedeoma pulegioides (L.) Pers.

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 36
Number of processed references:: 4

Compositions

#1: Trans-Isopulegone in essential oil #2: menthone in essential oil #3: piperitenone in essential oil #4: pulegone in whole plant

Endpoint Studies

#1: Case report - Acute kidney injury #2: Case report - Seizures, liver failure, altered mental status, metabolic acidosis, death or survival after prolonged illness

Genotoxicity

Composition #1: Wishart, DS., Jewison, T., Guo, AC., Wilson, M., Knox, C., Liu, Y., Djoumbou, Y., Mandal, R., Aziat, F., Dong, E., Bouatra, S., Sinelnikov, I., Arndt, D., Xia, J., Liu, P., Yallou, F., Bjorndahl, T., Perez-Pineiro, R., Eisner, R., Allen, F., Neveu, V., Greiner, R., Scalbert, A. (-)-trans-Isopulegone (HMDB35741).. human metabolome database, 2012, vol. 3.0 . .

Language:

English (en)
Substance:

trans-isopulegone (RF-00004088-PAR)
Additional substance description:

Trans-Isopulegone
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Trans-Isopulegone in essential oil

Composition #2: HANDA, KL., NIGAM, IC., SMITH, DM., LEVI, L. ESSENTIAL OILS + THEIR CONSTITUENTS .23. CHEMOTAXONOMY OF GENUS MENTHA. journal of pharmaceutical sciences, 1964, vol. 53, no. 11, p. 1407–&. DOI: 10.1002/jps.2600531129. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

menthone (RF-00011280-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Percent (G138A)
Result expression:

Reconstituted product (B007A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.4
Internal remarks:

menthone in essential oil

Composition #3: HANDA, KL., NIGAM, IC., SMITH, DM., LEVI, L. ESSENTIAL OILS + THEIR CONSTITUENTS .23. CHEMOTAXONOMY OF GENUS MENTHA. journal of pharmaceutical sciences, 1964, vol. 53, no. 11, p. 1407–&. DOI: 10.1002/jps.2600531129. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

p-Mentha-1,4(8)-dien-3-one (RF-00009950-PAR)
Additional substance description:

syn for piperitenone
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Percent (G138A)
Result expression:

Reconstituted product (B007A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.4
Internal remarks:

piperitenone in essential oil

Composition #4: SLECKMAN, BP., SHERMA, J., MINEO, LC. DETERMINATION OF PULEGONE IN H-PULEGIOIDES AND PEPPERMINT OIL BY THIN-LAYER CHROMATOGRAPHY WITH DENSITOMETRY . journal of liquid chromatography, 1983, vol. 6, no. 7, p. 1175–1182. DOI: 10.1080/01483918308079989. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol absolute
Substance:

(+)-pulegone (RF-00003398-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

pulegone in whole plant

Endpoint study #1: Luyckx, V.A. Nephrotoxicity of Alternative Medicine Practice. advances in chronic kidney disease, 2012, vol. 19, no. 3, p. 129–141. DOI: 10.1053/j.ackd.2012.04.005. [DOI link]

Study relevance:

Human health
Plant part:

Unspecified (A07XD)
Type of toxicological test:

case report (CHD060TT)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

Acute kidney injury: Edematous hemorrhagic kidneys, acute tubular necrosis, hepatorenal syndrome
Effect or parameter linked to the endpoint:

gross pathology (CHD022BE)
Internal remarks:

Case report - Acute kidney injury

Endpoint study #2: Luyckx, V.A. Nephrotoxicity of Alternative Medicine Practice. advances in chronic kidney disease, 2012, vol. 19, no. 3, p. 129–141. DOI: 10.1053/j.ackd.2012.04.005. [DOI link]

Study relevance:

Human health
Plant part:

Unspecified (A07XD)
Type of toxicological test:

case report (CHD060TT)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

SYSTEMIC (TOX01A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

Seizures, liver failure, altered mental status, metabolic acidosis, death or survival after prolonged illness
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

Case report - Seizures, liver failure, altered mental status, metabolic acidosis, death or survival after prolonged illness