EFSA
ecomole
vscht
  2. Guatteria gaumeri Greenm. // Annona depressa Baill. // Malmea depressa (Baill.) R. E. Fr. // Mosannona depressa (Baill.) Chatrou

Guatteria gaumeri Greenm. // Annona depressa Baill. // Malmea depressa (Baill.) R. E. Fr. // Mosannona depressa (Baill.) Chatrou

Family:
Annonaceae
Approval state:
Approved
Number of articles retrieved:
28
Number of processed references:
5
Compositions
#1: Guattegaumerine in bark
Endpoint Studies
#1: reproduction toxicity male mice following consumption of a-asarone #2: Ptosis and reduced weight gains in mice following consumption of a-asarone #3: post-implantation losses in female mice following consumption of a-asarone #4: reproduction toxicity in mice
Genotoxicity
#1: a- asarone genotoxicity with/without metabolic activation #2: mutagenicity associated with a-asarone #3: genotoxicity associated with a-asarone
Composition #1: DEHAUSSY, H., TITS, M., ANGENOT, L. GUATTEGAUMERINE, NEW BISBENZYLISOQUINOLINE ALKALOID FROM GUATTERIA-GAUMERI . planta medica, 1983, vol. 49, no. 1, p. 25–27. DOI: 10.1055/s-2007-969803. [DOI link]
Endpoint study #1: Chamorro, G., Garduno, L., Martinez, E., Madrigal, E., Tamariz, J., Salazar, M. Dominant lethal study of alpha-asarone in male mice. toxicology letters, 1998, vol. 99, no. 2, p. 71–77. DOI: 10.1016/S0378-4274(98)00041-1. [DOI link]
Endpoint study #2: Chamorro, G., Garduno, L., Martinez, E., Madrigal, E., Tamariz, J., Salazar, M. Dominant lethal study of alpha-asarone in male mice. toxicology letters, 1998, vol. 99, no. 2, p. 71–77. DOI: 10.1016/S0378-4274(98)00041-1. [DOI link]
Endpoint study #3: Chamorro, G., Garduno, L., Martinez, E., Madrigal, E., Tamariz, J., Salazar, M. Dominant lethal study of alpha-asarone in male mice. toxicology letters, 1998, vol. 99, no. 2, p. 71–77. DOI: 10.1016/S0378-4274(98)00041-1. [DOI link]
Endpoint study #4: Chellian, Ranjithkumar., Pandy, Vijayapandi., Mohamed, Zahurin. Pharmacology and toxicology of alpha- and beta-Asarone: A review of preclinical evidence . phytomedicine, 2017, vol. 32, p. 41–58. DOI: 10.1016/j.phymed.2017.04.003. [DOI link]
Genotox #1: MORALESRAMIREZ, P., MADRIGALBUJAIDAR, E., MERCADERMARTINEZ, J., CASSANI, M., GONZALEZ, G., CHAMORROCEVALLOS, G., SALAZARJACOBO, M. SISTER-CHROMATID EXCHANGE INDUCTION PRODUCED BY INVIVO AND INVITRO EXPOSURE TO ALPHA-ASARONE . mutation research, 1992, vol. 279, no. 4, p. 269–273. DOI: 10.1016/0165-1218(92)90243-S. [DOI link]
Genotox #2: CHAMORRO, G., SALAZAR, M., SALAZAR, S., MENDOZA, T. PHARMACOLOGY AND TOXICOLOGY OF GUATTERIA-GAUMERI. revista de investigacion clinica-clinical and translational investigation, 1993, vol. 45, no. 6, p. 597–604. .
Genotox #3: CHAMORRO, G., SALAZAR, M., SALAZAR, S., MENDOZA, T. PHARMACOLOGY AND TOXICOLOGY OF GUATTERIA-GAUMERI. revista de investigacion clinica-clinical and translational investigation, 1993, vol. 45, no. 6, p. 597–604. .