Draft - work in progress
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- Gossypium herbaceum L.
Gossypium herbaceum L.
- Family:
- Malvaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 1162
- Number of processed references:
- 3
Composition #1: Stipanovic, Robert D., Puckhaber, Lorraine S., Bell, Alois A., Percival, Albert E., Jacobs, John. Occurrence of (+)- and (-)-Gossypol in Wild Species of Cotton and in Gossypium hirsutum Var. marie-galante (Watt) Hutchinson. journal of agricultural and food chemistry, 2005, vol. 53, no. 16, p. 6266–6271. .
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
A derivatizing reagent [88% UV-grade acetonitrile, 10% glacial acetic acid, and 2% (R)-(-)-2-amino-1-propanol] was prepared.
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Substance:
Free gossypol (RF-00000332-TOX)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
59.3-71.0
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Internal remarks:
Gossypol in seeds
Endpoint study
#1: Nath, D., Sethi, N., Srivastava, S., Jain, A. K., Srivastava, R. Teratogenic evaluation of an indigenous antifertility medicinal plant Gossypium herbaceum in rat . fitoterapia, 1997, vol. 68, no. 2, p. 137–139. .
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Study relevance:
Human health
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Plant part:
Seed (as part-nature) (A066P)
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Type of toxicological test:
reproduction toxicity (CHD009TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Control groups used:
no data
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligrams per kilogram body weight (G225A)
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Effect concentration:
200
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Critical effect:
DEVELOPMENTAL (TOX07A)
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Target tissue:
urogenital: Uterus (TT052A)
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Effect description:
Seed suspension of orally administered at the dose of 200 mg/kg to pregnant rats, caused abortion of 57.14% foetuses. Where pregnancy was not interrupted, marked malformation in the newborns were seen.
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Effect or parameter linked to the endpoint:
development (CHD006BE)
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Internal remarks:
Seed suspension of orally administered at the dose of 200 mg/kg to pregnant rats, caused abortion of 57.14% foetuses. Where pregnancy was not interrupted, marked malformation in the newborns were seen.
Endpoint study
#2: Mello, Joao R. B., Mello, Fernanda B., Etges, Rodrigo N., Hollenbach, Clarissa., Rodrigues, Juliano M., Hirtz, Lucas. Pre-clinic toxicity of a phytotherapic containing Gossypium herbaceum (cotton plant) in Wistar rats . latin american journal of pharmacy, 2008, vol. 27, no. 1, p. 46–55. .
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Study relevance:
Human health
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Type of toxicological test:
short-term toxicity (CHD017TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Wistar (CHD013ST)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Unit of exposure duration:
Day (G134A)
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Control groups used:
yes, concurrent no treatment
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Gram (G148A)
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Critical effect:
SYSTEMIC (TOX01A)
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Target tissue:
Cardiovascular / Haematological (TT001A)
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Effect description:
The alterations observed in the weight gain, hematological values and biochemical blood analyses in the doses equivalent to 5 and 10 times the therapeutic doses revealed systemic toxicity, in a dose related manner.
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Effect or parameter linked to the endpoint:
body weight (CHD005BE)
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Internal remarks:
Rats: The alterations observed in the weight gain, hematological values and biochemical blood analyses in the doses equivalent to 5 and 10 times the therapeutic doses revealed systemic toxicity, in a dose related manner.
